环己基月桂酸酯 | 6301-70-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 环己基月桂酸酯
• 英文名称: cyclohexyl laurate
• 英文别名: cyclohexyl dodecanoate
• CAS: 6301-70-8
• 化学式: C₁₈H₃₄O₂
• 分子量: 282.467
• InChiKey: PJPLDEHITPGDLR-UHFFFAOYSA-N

物化性质

• LogP：
  7.343 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  月桂酸 在 镍 、 对甲苯磺酸 、 xylene 作用下， 150.0 ℃ 、9.81 MPa 条件下， 生成 环己基月桂酸酯
  参考文献：
  名称：

  Matsuda; Kikkawa, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1956, vol. 59, p. 895,897

  摘要：

  DOI：

文献信息

• 2,2,6,6-Tetramethylpiperidinium triflate (TMPT): a highly selective and self-separated catalyst for esterification
  作者：Lan Gao、Taoping Liu、Xiaochun Tao、Yongmin Huang

  DOI：10.1016/j.tetlet.2016.09.061

  日期：2016.11

  An eco-friendly and readily accessible 2,2,6,6-tetramethylpiperidinium triflate was found as highly-selective and self-separated catalyst for esterification under solvent-free condition. The X-ray crystallography revealed that it formed a ‘hydrophobic wall’ which could effectively eliminate the generated water from the reactive sites. Moreover, it could precipitate from the reaction system with excellent

  发现一种环保且易于获得的三氟甲磺酸2,2,6,6-四甲基哌啶鎓是在无溶剂条件下酯化的高选择性和自分离催化剂。X射线晶体学显示它形成了一个“疏水壁”，可以有效地消除反应位点产生的水。而且，它可以以优异的回收率（> 99％）从反应体系中沉淀出来，可以重复使用十次而活性没有任何显着损失。
• [EN] SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP)<br/>[FR] PYRIDONES SUBSTITUES INHIBITEURS DE LA POLY(ADP-RIBOSE) POLYMERASE (PARP)
  申请人：AVENTIS PHARMA INC

  公开号：WO2005097750A1

  公开（公告）日：2005-10-20

  The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

  本发明公开并声明了一系列如下定义的2,3,5-取代吡啶酮衍生物。本发明还涉及制备这些化合物的方法。本发明的化合物是多聚腺苷酸二磷酸核糖酶（PARP）的抑制剂，因此在制药剂中特别用于治疗和/或预防各种疾病，包括与中枢神经系统和心血管疾病相关的疾病。
• Development and Applications of Transesterification Reactions Catalyzed by N-Heterocyclic Olefins
  作者：Marcus Blümel、Janina-Miriam Noy、Dieter Enders、Martina H. Stenzel、Thanh V. Nguyen

  DOI：10.1021/acs.orglett.6b00835

  日期：2016.5.6

  A novel method to utilize N-heterocyclic olefins (NHOs), the alkylidene derivatives of N-heterocycic carbenes, as organocatalysts to promote transesterification reactions has been developed. Because of their strong Brønsted/Lewis basicity, NHOs can enhance the nucleophilicity of alcohols for their acylation reactions with carboxylic esters. This transformation can be employed in industrially relevant

  已经开发出一种利用N-杂环卡宾的亚烷基衍生物N-杂环烯烃（NHO）作为有机催化剂来促进酯交换反应的新方法。由于其强大的Brønsted/ Lewis碱性，NHO可以增强醇与羧酸酯的酰化反应的亲核性。这种转化可用于与工业相关的过程中，例如生产生物柴油，从塑料瓶中解聚聚对苯二甲酸乙二醇酯（PET）以便回收利用，以及环酯的开环聚合以形成可生物降解的聚合物，例如聚丙交酯（PLA）和聚己内酯（PCL）。
• The carbon material functionalized with NH₂⁺ and SO₃H groups catalyzed esterification with high activity and selectivity
  作者：Shaoqi Zhan、Xiaochun Tao、Liangzhen Cai、Xiaohui Liu、Taoping Liu

  DOI：10.1039/c4gc01395f

  日期：——

  A novel carbon material was prepared conveniently, which can catalyze the esterification reaction with high reactivity and selectivity.

  一个新型碳材料被方便地制备出来，可以催化酯化反应，具有高反应活性和选择性。
• Mild Esterification and Transesterification of Carboxylic Acids Catalyzed by Tetracyanoethylene and Dicyanoketene Dimethyl Acetal
  作者：Yukio Masaki、Nobuyuki Tanaka、Tsuyoshi Miura

  DOI：10.1246/cl.1997.55

  日期：1997.1

  A π-acid tetracyanoethylene (TCNE) and its derivative dicyanoketene dimethyl acetal (DCKDMA) were found to catalyze esterification of lauric acid with various types of alcohols. This mathod was successfully applied to methyl esterification of a variety of carboxylic acids including aromatic, α,β-unsaturated, α-hydroxy, and N-Cbz and N-Boc-protected α-amino acids without racemization at the range from

  发现 π 酸四氰基乙烯 (TCNE) 及其衍生物二氰基烯酮二甲基乙缩醛 (DCKDMA) 可催化月桂酸与各种醇的酯化反应。该方法成功地应用于多种羧酸的甲酯化，包括芳香族、α,β-不饱和、α-羟基和 N-Cbz 和 N-Boc 保护的 α-氨基酸，在室温至60℃。还发现 TCNE 在月桂酸甲酯的酯交换反应中用作催化剂。