galactitol-1-phosphate | 15664-55-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: galactitol-1-phosphate
• 英文别名: Galactitol 1-phosphate；[(2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexyl] dihydrogen phosphate
• CAS: 15664-55-8
• 化学式: C₆H₁₅O₉P
• 分子量: 262.153
• InChiKey: GACTWZZMVMUKNG-DPYQTVNSSA-N

物化性质

• 沸点：
  701.4±70.0 °C(Predicted)
• 密度：
  1.844±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  168
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  Α-D-乳酸吡喃糖苷甲酯 在 palladium dihydroxide 甲醇 、 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 正丁基锂 、 硫酸 、 氢气 、 碘 、 四丁基碘化铵 、 sodium hydride 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 56.5h， 生成 galactitol-1-phosphate
  参考文献：
  名称：

  Synthesis and Analysis of Substrate Analogues for UDP-Galactopyranose Mutase:  Implication for an Oxocarbenium Ion Intermediate in the Catalytic Mechanism

  摘要：

  UDP-D-galactofuranose ( 2), which is essential for both cell growth and virulence in many pathogenic microorganisms, is converted from UDP-D-galactopyranose (UDP-Galp, 1) by the flavin adenine dinucleotide (FAD)-dependent enzyme UDP-galactopyranose mutase (UGM). Here, we report the synthesis of UDP-GalOH ( 13) and show it as an inhibitor for UGM with a binding affinity similar to that of 1. These results are more consistent with a mechanism involving an oxocarbenium ion intermediate in UGM catalysis.

  DOI：

  10.1021/ol0631408

文献信息

• MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS
  申请人：Genomatica, Inc.

  公开号：US20150148513A1

  公开（公告）日：2015-05-28

  The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.

  该发明提供了具有4-羟基丁酸、1,4-丁二醇或其他产物途径并能够产生4-羟基丁酸、1,4-丁二醇或其他产物的非自然微生物生物体，其中该微生物生物体包括一个或多个基因修饰。该发明还提供了利用这些微生物生物体生产4-羟基丁酸、1,4-丁二醇或其他产物或相关产品的方法。
• Novel phosphobetaine and detergent and cosmetic containing the same
  申请人：Kao Corporation

  公开号：EP0514588A2

  公开（公告）日：1992-11-25

  A novel phosphobetaine is disclosed. This compound is very excellence in that it exerts a conditioning effect of imparting a good feel to the skin or hair, is excellent in humidifying properties, is available at a low price, and thus it is highly usable in detergents, cosmetics, a bathing preparation and the like. A detergent composition, a cosmetic, and a bathing preparation each containing the phosphobetaine are also disclosed.

  本研究公开了一种新型磷脂酰基化合物。这种化合物非常出色，它具有调理作用，能给皮肤或头发带来良好的触感，具有极佳的加湿性能，而且价格低廉，因此在洗涤剂、化妆品、沐浴剂等方面具有很高的实用性。此外，还公开了一种洗涤剂组合物、一种化妆品和一种沐浴剂，它们都含有磷脂质。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• MICRORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL
  申请人：Genomatica, Inc.

  公开号：EP3514242A2

  公开（公告）日：2019-07-24

  The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

  本发明提供了包含 1，4-丁二醇（BDO）途径的非天然微生物，该途径包含至少一种外源核酸，该核酸编码的 BDO 途径酶表达量足以产生 BDO。本发明还提供了使用这种微生物生产 BDO 的方法。
• Microorganisms for the production of 1,4-butanediol and related methods
  申请人：Genomatica, Inc.

  公开号：US10273508B2

  公开（公告）日：2019-04-30

  The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

  本发明提供了包含 1，4-丁二醇（BDO）途径的非天然存在的微生物有机体，该微生物有机体包含至少一种外源核酸，该核酸编码的 BDO 途径酶表达量足以产生 BDO，并进一步优化了 BDO 的表达。本发明还提供了使用这种微生物生产 BDO 的方法。