palladium dihydroxide

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 英文名称: palladium dihydroxide
• 英文别名: palladium (II) hydroxide；Pearlman's catalyst；palladium hydroxide；palladium hydroxyde；palladium hydroxide on coal；Palladium(2+);hydroxide
• 化学式: 2HO*Pd
• 分子量: 140.435
• InChiKey: MOICSOWNMLCCJF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.18
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  palladium dihydroxide 、 (+)-1-(1-hydroxyethyl)phenoxathiin 10,10-dioxide 在 氮气 、 氢气 作用下， 以 aqueous perchloric acid 、 水 、 溶剂黄146 为溶剂， 生成 1-乙基吩恶噻10,10-二氧化物
  参考文献：
  名称：

  Pharmacologically active compound and use

  摘要：

  1-乙基苯氧硫啶10,10-二氧化物（I）抑制单胺氧化酶A，对治疗抑郁等疾病有用。

  公开号：

  US05420156A1
• 作为试剂：
  描述：

  1,2,5,6-四羟基己烷 在 咪唑 、 4-二甲氨基吡啶 、 palladium dihydroxide 、 氢气 、 三乙胺 作用下， 生成 (2S,5S)-2,5-bis[tert-butyl(dimethyl)silyloxymethyl]pyrrolidine
  参考文献：
  名称：

  Symmetry-Assisted Synthesis of C₂-Symmetric trans-α,α‘-Bis(hydroxymethyl)pyrrolidine and -piperidine Derivatives via Double Sharpless Asymmetric Dihydroxylation of α,ω-Terminal Dienes

  摘要：

  A new strategy has been developed for the synthesis of C-2-symmetric trans-alpha,alpha'-bis(hydroxymethyl)pyrrolidine and piperidine derivatives 1-3 starting from symmetric alpha,omega-terminal dienes 4-6. The double-asymmetric dihydroxylation (AD) reaction of 4-6 gave C-2-symmetric tetrols, which were converted in a four-step sequence to C-2-symmetric azacycloalkanes 17, 9, and 22, respectively. These azacycloalkanes were transformed into 1-3 in high enantiomeric excess (82% --> 98%ee). The double AD reaction proved to cause enantiomeric enhancement, even though the asymmetric induction for the first AD reaction is moderate. In addition, it was observed that the chromatography on silica gel of several C-2-symmetric azacycloalkanes (17, 20, and 22) of varying ee's resulted in marked enantiomeric fractionation.

  DOI：

  10.1021/jo971995f

文献信息

• Mercapto-acylamino acid antihypertensives
  申请人：Schering Corporation

  公开号：US05061710A1

  公开（公告）日：1991-10-29

  Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.

  新型巯基-酰胺基酸在治疗高血压方面很有用，公开了巯基-酰胺基酸和心房利钠因子或抑制血管紧张素转化酶的组合物，用于治疗高血压。
• Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
  申请人：Pharmacia & Upjohn Company

  公开号：US05652238A1

  公开（公告）日：1997-07-29

  A compound of structural Formula (I) or pharmaceutically acceptable salts thereof wherein: R is --C(O)--R.sup.1, --PO.sub.3 .dbd. or --P(O)(OH).sub.2 ; R.sup.1 is C.sub.1-6 alkyl, --N(R.sup.4).sub.2, C.sub.1-6 alkyl-N(R.sup.4).sub.2, --phenyl--N(R.sup.4).sub.2, --phenyl-NHC(O)CH.sub.2 NH.sub.2, --C.sub.2 H.sub.4 -morpholinyl, pyridinyl, C.sub.1-6 alkyl-OH, C.sub.1-6 alkyl-OCH.sub.3, C.sub.1-6 alkyl C(O)CH.sub.3, --O--C.sub.1-6 alkyl-OCH.sub.3, C.sub.0-3 alkyl-piperazinyl (optionally substituted with C.sub.1-3 alkyl), imidazolyl, C.sub.1-6 alkyl-COOH, --C(CH.sub.2 OH).sub.2 CH.sub.3 ; R.sup.2 and R.sup.3 are independently selected from hydrogen or F except at least one of R.sup.2 or R.sup.3 is F; R.sup.4 are independently selected from hydrogen or C.sub.1-6 alkyl. The compounds are water soluble and are useful antimicrobial agents, effective against a number of human veterinary pathogens, including multiply-resistant staphylococci, enterococci and streptococci, as well as anerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis.

  结构式（I）的化合物或其药用盐，其中：R为--C(O)--R.sup.1，--PO.sub.3 .dbd.或--P(O)(OH).sub.2；R.sup.1为C.sub.1-6烷基，--N(R.sup.4).sub.2，C.sub.1-6烷基-N(R.sup.4).sub.2，--苯基--N(R.sup.4).sub.2，--苯基-NHC(O)CH.sub.2 NH.sub.2，--C.sub.2 H.sub.4 -吗啉基，吡啶基，C.sub.1-6烷基-OH，C.sub.1-6烷基-OCH.sub.3，C.sub.1-6烷基C(O)CH.sub.3，--O--C.sub.1-6烷基-OCH.sub.3，C.sub.0-3烷基-哌嗪基（可选择性地取代为C.sub.1-3烷基），咪唑基，C.sub.1-6烷基-COOH，--C(CH.sub.2 OH).sub.2 CH.sub.3；R.sup.2和R.sup.3分别选择自氢或F，除非R.sup.2或R.sup.3中至少有一个为F；R.sup.4独立选择自氢或C.sub.1-6烷基。这些化合物可溶于水，是有用的抗菌剂，对多种人兽共患病原体具有有效作用，包括多重耐药葡萄球菌、肠球菌和链球菌，以及厌氧生物如拟杆菌和梭菌属，以及耐酸生物如结核分枝杆菌。
• Purine derivatives
  申请人：——

  公开号：US20020032168A1

  公开（公告）日：2002-03-14

  The present invention relates to compounds of the formula 1 and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as adenosine A2a receptor agonists.

  本发明涉及具有公式1的化合物，以及药用可接受的盐和溶剂化物，还涉及用于制备这些化合物的过程、在制备中使用的中间体，以及包含这些化合物的组合物，以及这些化合物作为腺苷A2a受体激动剂的使用。
• Angiotensin II antagonists incorporating a substituted thiophene or furan
  申请人：Merck & Co., Inc.

  公开号：US05177074A1

  公开（公告）日：1993-01-05

  There are disclosed substituted thiophene and furan derivatives of Formula I which are useful as angiotensin II antagonists. ##STR1##

  已公开的Formula I的取代噻吩和呋喃衍生物可用作血管紧张素II拮抗剂。
• Angiotensin II antagonists incorporating a substituted pyridoimidazolyl
  申请人：Merck & Co., Inc.

  公开号：US05240938A1

  公开（公告）日：1993-08-31

  Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##

  通过一个亚甲基桥连接到新的取代苯基衍生物的取代杂环对式I的化合物可作为血管紧张素II拮抗剂。