2-氯-5-醛基苯硼酸 | 1150114-78-5

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 环羧酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-5-醛基苯硼酸
• 中文别名: 2-氯-5-甲酰基苯基硼酸
• 英文名称: 2-chloro-5-(hydroxymethyl)phenylboronic acid
• 英文别名: (2-chloro-5-formylphenyl)boronic acid；2-Chloro-5-formylphenylboronic acid
• CAS: 1150114-78-5
• 化学式: C₇H₆BClO₃
• mdl: MFCD06656269
• 分子量: 184.387
• InChiKey: BGTXLDYEFFSFNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  C
• 海关编码：
  2931900090
• 危险类别：
  IRRITANT
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Chloro-5-formylphenylboronic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Chloro-5-formylphenylboronic acid
CAS number: 1150114-78-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H6BClO3
Molecular weight: 184.4

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氯-5-醛基苯硼酸 在 sodium tetrahydroborate 、 magnesium sulfate 、 potassium carbonate 、 一水合肼 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 98.0h， 生成 (4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine
  参考文献：
  名称：

  含硼伯胺的合成

  摘要：

  在这项研究中，合成了含硼伯胺，用作类肽研究中的构建块。在第一步中，对 Gabriel 合成条件进行了修改，以能够以良好到优异的产率构建七种不同的氨基甲基苯基硼酸酯。这些化合物通过微波辐射下的 Ugi 四组分反应 (Ugi-4CR) 进一步用于构建类肽类似物。然后将制备的 Ugi-4CR 硼酸酯成功转化为相应的硼酸。最后，通过钯介导的 Suzuki 偶联反应与芳基/杂芳基氯化物交叉偶联，成功地修饰了拟肽结构，以中等至良好的产率得到相应的衍生物。

  DOI：

  10.3390/molecules181012346

文献信息

• HETEROARYLS AND USES THEREOF
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：US20130165464A1

  公开（公告）日：2013-06-27

  This invention provides compounds of formula IB: and also provides compounds of formulas ID, IIB, VB, and IIC: wherein HY, R 1 , R 2 , G 5 , G 6 , G 7 , G 8 , and G 9 are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

  这项发明提供了以下式IB的化合物： 并且还提供了以下式ID、IIB、VB和IIC的化合物： 其中HY、R1、R2、G5、G6、G7、G8和G9如规范中所述。这些化合物是VPS34和/或PI3K的抑制剂，因此对于治疗增殖性、炎症性或心血管疾病是有用的。
• Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold
  作者：Zheng Li、Chunxia Liu、Jianyong Yang、Jiaqi Zhou、Zhiwen Ye、Dazhi Feng、Na Yue、Jiayi Tong、Wenlong Huang、Hai Qian

  DOI：10.1016/j.ejmech.2019.06.087

  日期：2019.10

  on an old phenoxyacetic acid scaffold, CPU014 (compound 14) has been identified as a superior agonist by comprehensive exploration of structure-activity relationship. In vitro toxicity study suggested that CPU014 has lower risk of hepatotoxicity than TAK-875. During acute toxicity study (5–500 mg/kg), a favorable therapeutic window of CPU014 was observed by evaluation of plasma profiles and liver slices

  基于旧的苯氧乙酸支架，通过全面探索结构-活性关系，CPU014（化合物14）被确定为优良的激动剂。体外毒性研究表明，CPU014的肝毒性风险低于TAK-875。在急性毒性研究（5-500 mg / kg）中，通过评估血浆谱和肝切片观察到了CPU014的有利治疗窗口。此外，CPU014以葡萄糖依赖的方式促进胰岛素分泌，而GLP-1的分泌却没有增加。除了良好的药代动力学特性，CPU014在正常和糖尿病模型中均显着提高了葡萄糖耐量，没有低血糖的风险。这些颠覆性发现提供了更安全的候选CPU014，目前正在临床前研究中评估其在糖尿病治疗中的潜力。
• Ligandless Nickel-Catalyzed <i>Ortho</i>-Selective Directed Trifluoromethylthiolation of Aryl Chlorides and Bromides Using AgSCF₃
  作者：Tin Nguyen、Weiling Chiu、Xinying Wang、Madeleine O. Sattler、Jennifer A. Love

  DOI：10.1021/acs.orglett.6b02689

  日期：2016.11.4

  A mild protocol for Ni-catalyzed trifluoromethylthiolation of aryl chlorides and bromides is described herein. The method utilizes AgSCF3 as an easily accessible nucleophilic trifluoromethylthiolating reagent and does not require any ligands or additives. Ortho-selectivity is achieved using a variety of directing groups such as imines, pyridines, and oxazolines for 24 examples in up to 95% yield.

  本文描述了Ni催化的芳基氯化物和溴化物的三氟甲基硫醇化的温和方案。该方法利用AgSCF 3作为容易获得的亲核三氟甲基硫醇化试剂，不需要任何配体或添加剂。对于24个实例，使用多种指导基团如亚胺，吡啶和恶唑啉实现邻位选择性，产率高达95％。
• Heteroaryls and uses thereof
  申请人：Cullis Courtney A.

  公开号：US08859768B2

  公开（公告）日：2014-10-14

  This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

  该发明提供了式IA或IB的化合物：其中HY、R1、R2和G1如说明书所述。这些化合物是VPS34和/或PI3K的抑制剂，因此可用于治疗增殖性、炎症性或心血管疾病。
• Synthesis of Boron-Containing Primary Amines
  作者：Sheng-Hsuan Chung、Ting-Ju Lin、Qian-Yu Hu、Chia-Hua Tsai、Po-Shen Pan

  DOI：10.3390/molecules181012346

  日期：——

  blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters in good to excellent yields. These compounds were further utilized to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation. The prepared Ugi-4CR boronate esters were then successfully converted

  在这项研究中，合成了含硼伯胺，用作类肽研究中的构建块。在第一步中，对 Gabriel 合成条件进行了修改，以能够以良好到优异的产率构建七种不同的氨基甲基苯基硼酸酯。这些化合物通过微波辐射下的 Ugi 四组分反应 (Ugi-4CR) 进一步用于构建类肽类似物。然后将制备的 Ugi-4CR 硼酸酯成功转化为相应的硼酸。最后，通过钯介导的 Suzuki 偶联反应与芳基/杂芳基氯化物交叉偶联，成功地修饰了拟肽结构，以中等至良好的产率得到相应的衍生物。