α-D-Manp-(1->2)-α-D-Manp | 50271-62-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-D-Manp-(1->2)-α-D-Manp
• 英文别名: α-D-Man-(1->2)-α-D-Man；α-D-(1-2)-mannobiose；2α-mannobiose；α-(1-2)-mannose disaccharide；α-D-Man-(1->2)-D-Man；2-O-Alpha-D-Mannopyranosyl-Alpha-D-Mannopyranose；(2S,3S,4S,5S,6R)-6-(hydroxymethyl)-3-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2,4,5-triol
• CAS: 50271-62-0
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: HIWPGCMGAMJNRG-LBGGPIGOSA-N

物化性质

• 沸点：
  700.9±60.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  α-D-Manp-(1->2)-α-D-Manp 、 乙酸酐 在 吡啶 作用下， 生成 1,3,4,6-tetra-O-acetyl-2-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-α-D-mannopyranose
  参考文献：
  名称：

  使用超分子水凝胶的荧光凝集素阵列对各种糖缀合物进行简单检测和模式分析

  摘要：

  由于糖及其衍生物在各种生物现象中发挥着重要作用，因此迫切需要对各种糖缀合物进行快速和高通量分析。我们在此描述了使用超分子水凝胶基质构建用于糖类检测的新型荧光凝集素阵列。在这个阵列中，荧光凝集素在半湿条件下被非共价固定以抑制蛋白质变性。荧光滴定和荧光寿命实验表明，固定化凝集素在水凝胶基质中充当分子识别支架，类似于在水溶液中。也就是说，双分子荧光淬灭和恢复 (BFQR) 方法可以在两种条件下成功运行。这使人们能够根据固定化凝集素的识别选择性和亲和力荧光读出一系列糖类，无需繁琐的洗涤过程，也无需标记目标糖类。使用本凝集素阵列对多种糖缀合物进行了简单且高通量的传感和分析，其中不仅包括简单的葡萄糖，还包括寡糖和糖蛋白，此外，还对几种类型的细胞裂解物进行了模式识别和分析也实现了。

  DOI：

  10.1021/ja0613963
• 作为产物：
  描述：

  2,3,4,6-四-O-乙酰基-1-溴-Alpha-D-甘露糖 在 palladium on activated charcoal 、 sodium methylate 4 A molecular sieve 、 氢气 、 sodium methylate 、 silver trifluoromethanesulfonate 、 sodium hydride 、 mercury dibromide 作用下， 以 四氢呋喃 、 甲醇 、 溶剂黄146 、 1,2-二氯乙烷 为溶剂， 反应 56.0h， 生成 α-D-Manp-(1->2)-α-D-Manp
  参考文献：
  名称：

  Synthesis of linear d-mannotetraose and d-mannohexaose, partial structures of the cell-surface d-mannan of Candida albicans and Candida utilis

  摘要：

  DOI：

  10.1016/s0008-6215(00)82588-4

文献信息

• [EN] SULFATED OLIGOSACCHARIDE DERIVATIVES<br/>[FR] DERIVES D'OLIGOSACCHARIDES SULFATES
  申请人：PROGEN IND LTD

  公开号：WO2005085264A1

  公开（公告）日：2005-09-15

  The invention relates to compounds which are polysufated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.

  该发明涉及一类多硫代寡糖衍生物化合物，具有抑制肝素硫酸盐结合蛋白和抑制肝素酶酶活性的作用；该发明还涉及这些化合物的制备方法；包含这些化合物的组合物；以及这些化合物和组合物在哺乳动物主体中用于抗血管生成、抗转移、抗炎、抗微生物、抗凝血和/或抗血栓治疗、降低血液甘油三酯水平以及抑制心血管疾病的用途。
• The extracellular polysaccharide of Pichia (Hansenula) holstii NRRL Y-2448: the phosphorylated side chains
  作者：Lesley A.S. Parolis、Haralambos Parolis、Lennart Kenne、Morten Meldal、Klaus Bock

  DOI：10.1016/s0008-6215(98)00101-3

  日期：1998.5

  The exopolysaccharide produced by Pichia (Hansenula) holstii NRRL Y-2448 is composed of a phosphomannan core to which oligosaccharide diester phosphate side chains are appended. The oligosaccharides of the side chains were released as oligosaccharide phosphates and neutral oligosaccharides by mild hydrolysis with aqueous acetic acid and aqueous hydrogen fluoride, respectively. The liberated oligosaccharide

  霍乱毕赤氏酵母NRRL Y-2448产生的胞外多糖由磷酸甘露聚糖核心组成，寡糖二酯磷酸酯侧链附于其上。通过分别用乙酸水溶液和氟化氢水溶液温和水解，侧链的寡糖分别以寡糖磷酸酯和中性寡糖释放。通过NMR光谱以及通过电喷雾和快速原子轰击质谱法研究了释放的寡糖磷酸酯。中性寡糖的结构通过1D和2D NMR光谱实验确定。
• Mannobiose derivatives
  申请人：MEITO SANGYO CO., LTD.

  公开号：EP0285178A2

  公开（公告）日：1988-10-05

  Novel mannobiose derivative represented by the general formula [I]: wherein groups of R₁ to R₅ each represents -OH, -OR₆, -NHR₆, (R₆ represents an acyl group) or a group represented by the following formula (a), (b), (c), (d) or (e), provided that one of R₁ to R₅ represents -OR₆ or -NHR₆, one of the other 4 groups of R₁ to R₅ represents one of the groups represented by the formulae (a) to (e), and the remaining 3 groups of R₁ to R₅ represent -OH: wherein represents α or β bond are provided by the invention. These compounds give liposomes a specific affinity for Kupffer cells of liver, and can be produced industrially.

  通式[I]代表的新型甘露寡糖衍生物： 其中R₁至R₅的基团各自代表-OH、-OR₆、-NHR₆、（R₆代表酰基）或下式(a)、(b)、(c)、(d)或(e)所代表的基团、条件是 R₁ 至 R₅ 中的一个代表-OR₆ 或-NHR₆，R₁ 至 R₅ 的另外 4 个基团中的一个代表式 (a) 至 (e) 所代表的基团之一，R₁ 至 R₅ 的其余 3 个基团代表-OH： 其中代表 α 或 β 键的基团由本发明提供。 这些化合物使脂质体对肝脏的 Kupffer 细胞具有特异性亲和力，并且可以工业化生产。
• Large scale production of recombinant .alpha.-1,2-mannosyltransferase from E. coli for the study of acceptor specificity and use of the recombinant whole cells in synthesis
  作者：Guido F. Herrmann、Peng Wang、Gwo-Jenn Shen、Eduardo Garcia-Junceda、Shaheer H. Khan、Khushi L. Matta、Chi-Huey Wong

  DOI：10.1021/jo00100a043

  日期：1994.10

  We report the first large scale heterologous expression of a recombinant yeast alpha-1,2-mannosyltransferase in E. coli. The enzyme was isolated from 10-L and 50-L fermentations, purified and used for mannosylation reactions. The specificity of the recombinant enzyme was extensively studied by using mannose derivatives, oligosaccharides, and analogs as accepters, and the results show that the enzyme exhibits high activities toward ManOMe and disaccharides connected by an alpha-1,2-mannosidic linkage. The recombinant E. coli cells were also used as a catalyst for glycosylation reaction, and mannosylation of saccharides and glycopeptides proceeded in moderate to good yields.
• Chemoenzymatic synthesis of the branched oligosaccharides which correspond to the core structures of N-linked sugar chains
  作者：Ichiro Matsuo、Megumi Isomura、Tatsuo Miyazaki、Tohru Sakakibara、Katsumi Ajisaka

  DOI：10.1016/s0008-6215(97)10001-5

  日期：1997.12

  Synthetic routes are described to a partial structure common to all high mannose-type sugar chains and complex-type sugar chains based on a chemoenzymatic strategy which incorporates, (a) enzymatic synthesis of oligosaccharide blocks using glycosidases, and (b) chemical synthesis of the branching oligosaccharides via regioselective coupling. All reaction products correspond to key intermediates necessary for the construction of N-linked oligosaccharides and we have synthesized the branched tetra-manno-oligosaccharide high mannose-type sugar chain and the branched hexa-oligosaccharide complex-type sugar chain using this simple and direct method. (C) 1998 Elsevier Science Ltd.