甘氨酰-L-色氨酸 | 2390-74-1

• 物质功能分类: 生物化工 - 常见氨基酸及蛋白质类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甘氨酰-L-色氨酸
• 中文别名: 甘氨酰色氨酸；甘氨酰-L-胰化蛋白氨基酸；甘氨酰-L-吲哚丙氨酸；甘氨酰-L-色氨酸水合物
• 英文名称: N-glycyl-L-tryptophan
• 英文别名: Gly-Trp；Glycyl-L-Tryptophan；glycyltryptophan；(2S)-2-[(2-azaniumylacetyl)amino]-3-(1H-indol-3-yl)propanoate
• CAS: 2390-74-1
• 化学式: C₁₃H₁₅N₃O₃
• mdl: MFCD27756519
• 分子量: 261.28
• InChiKey: AJHCSUXXECOXOY-NSHDSACASA-N

物化性质

• 沸点：
  621.8±55.0 °C(Predicted)
• 密度：
  1.383±0.06 g/cm3(Predicted)
• 溶解度：
  在5mol/LHCl中几乎透明

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  甘氨酰-L-色氨酸 在 吡啶硼烷 、 三氟乙酸 作用下， 反应 0.03h， 生成
  参考文献：
  名称：

  Fast mass spectrometry detection of tryptophan-containing peptides and proteins by reduction with pyridine–borane

  摘要：

  In this note, we describe a method devised to detect, by means of mass spectrometry (MS), tryptophan-containing peptides and proteins using pyridine-borane. This reagent selectively reduces tryptophan residues, converting them to 2,3-dihydro-tryptophan, thereby enabling quantitation of tryptophans. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.ab.2013.05.005
• 作为产物：
  描述：

  N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-L-tryptophan 在 水 、 一水合肼 作用下， 生成 甘氨酰-L-色氨酸
  参考文献：
  名称：

  Preparation of peptides

  摘要：

  公开号：

  US02498665A1

文献信息

• New fluorogenic substrates for microdetermination of carboxypeptidase A.
  作者：EISUKE SATO、YUICHI KANAOKA

  DOI：10.1248/cpb.36.4494

  日期：——

  As a part of the development of a sensitive fluorometric assay for the activity of carboxypeptidase A, bimane-peptides containing tryptophan, i.e., S-[9, 10-dioxa-syn-(methyl, methyl).-(methylene, methyl)-bimane]-thioglycoly1-(glycyl)-L-tryptophan and O-S-[9, 10-dioxa-syn-(methyl, methyl)(methylene, methyl)-bimane]-thioglycolyl}-DL-3-indolelactic acid, were prepared and shown be good fluorogenic substrates for microdetermination of carboxypeptidase A activity.

  作为对羧肽酶A活性敏感荧光测定法开发的一部分，制备了含有色氨酸的双苯乙烯肽，即S-[9, 10-二氧-反-(甲基, 甲基).-(亚甲基, 甲基)-双苯乙烯]-硫代乙酸-(甘氨酸)-L-色氨酸和O-S-[9, 10-二氧-反-(甲基, 甲基)(亚甲基, 甲基)-双苯乙烯]-硫代乙酸}-DL-3-吲哚乳酸，并显示出它们是微量测定羧肽酶A活性的良好荧光底物。
• Organic fluorescent reagents. Part XVII. New fluorogenic substrates for microdetermination of cathepsin C.
  作者：Eisuke SATO、Kohki MATSUDA、Yuichi KANAOKA

  DOI：10.1248/cpb.38.2043

  日期：——

  As a sensitive fluorometric assay for the activity of cathepsin C, bimane-peptides containing tryptophan were synthesized and shown to be fluorogenic substrates for the microdetermination of cathepsin C activity.

  作为一种敏感的荧光测定法，用于测定胱蛋白酶C的活性，合成了含有色氨酸的双明肽，并证明其是用于微量测定胱蛋白酶C活性的荧光基质。
• Among the Missing: Content on Lesbian and Gay People in Social Work Journals
  作者：R. Van Voorhis、M. Wagner

  DOI：10.1093/sw/47.4.345

  日期：2002.10.1

  Lesbian and gay issues are barely visible in the social work literature. This study examined the content of articles on homosexuality that were published in four major social work journals between 1988 and 1997. Articles were coded according to their focus on either HIV/AIDS and the gay community or other issues pertaining to lesbians and gay men. Articles were also coded as client focused, worker focused, or macro focused. Two-thirds of the 77 articles published on homosexuality focused on HIV/AIDS. Most articles reflected a problem-oriented view of gay and lesbian people; few addressed heterosexism or environmental interventions. More literature is needed that focuses on strengths, heterosexist conditions, and social justice for lesbian and gay people.

  在社会工作文献中，关于同性恋和同性恋者的问题几乎没有被提及。本研究考察了1988年至1997年间在四本主要社会工作期刊上发表的关于同性恋的文章内容。文章根据关注点被编码为HIV/AIDS与同性恋社区或其他与女同性恋者和男同性恋者有关的问题。文章还被编码为以客户为中心、以工作者为中心或宏观为中心。在77篇关于同性恋的文章中，三分之二集中于HIV/AIDS。大多数文章反映了对同性恋者的以问题为导向的观点；很少有文章涉及异性恋主义或环境干预。需要更多关注同性恋者和女同性恋者优势、异性恋主义条件及社会公正的文献。
• Identification of Novel<scp>L</scp>-Amino Acid α-Ligases through Hidden Markov Model-Based Profile Analysis
  作者：Akihiro SENOO、Kazuhiko TABATA、Yoshiyuki YONETANI、Makoto YAGASAKI

  DOI：10.1271/bbb.90644

  日期：2010.2.23

  l-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected l-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.

  l- 氨基酸 α-连接酶（Lal）以 ATP 依赖性方式催化未受保护的 l- 氨基酸形成 α-二肽，被用于经济高效的二肽发酵生产。我们利用基于隐马尔可夫模型的剖面分析方法，通过硅筛选寻找新型拉尔，结果发现了五种新型拉尔，它们与已知拉尔的相似性较低，底物特异性也不同。
• Determination of Rate Constants for Reactions of Bichloride Anion Radical with Some Dipeptides in Aqueous Solution of KCl and K₂S₂O₈by Flash Photolysis
  作者：Osamu Neda、Kotaro Yamauchi、Takahiro Masuda

  DOI：10.1246/bcsj.58.227

  日期：1985.1

  chloride ion to dichloride anion radical through reaction with hydrated electron produced by photolysis of chloride ion. For glycyltryptophan, the competition method was employed, because its transient absorption overlaps the absorption due to dichloride anion radical. The rate constants determined are almost the same as those obtained in N2O-saturated aqueous solution of KCl (1 mol dm−3). The reactivity

  二氯阴离子自由基反应的速率常数的测定是通过传统的 KCl 和 K2S2O8 水溶液的闪光光解进行的，其中没有 HOCL-· 参与二氯阴离子自由基的衰变动力学。确定的最佳条件是 0.1 mol dm-3 KCl 和 10-4 mol dm-3 K2S2O8。在目前的实验条件下，S2O82- 通过与氯离子光解产生的水合电子反应，将氯离子转化为二氯阴离子自由基。对于甘氨酰色氨酸，采用竞争法，因为其瞬时吸收与二氯阴离子自由基的吸收重叠。测定的速率常数与在 N2O 饱和的 KCl 水溶液 (1 mol dm-3) 中获得的速率常数几乎相同。

表征谱图