甘氨酰-L-脯氨酸-4-甲氧基-Β-萘胺 | 42761-76-2

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 脯氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甘氨酰-L-脯氨酸-4-甲氧基-Β-萘胺
• 中文别名: H-甘氨酸-脯氨酸-4MΒNA
• 英文名称: glycyl-prolyl-4-methoxy-β-naphthylamide
• 英文别名: Gly-Pro 4-methoxy-beta-naphthylamide；(2S)-1-(2-aminoacetyl)-N-(4-methoxynaphthalen-2-yl)pyrrolidine-2-carboxamide
• CAS: 42761-76-2
• 化学式: C₁₈H₂₁N₃O₃
• mdl: MFCD00037726
• 分子量: 327.383
• InChiKey: LSZPYDQEJZWJIJ-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  84.7
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S36
• 危险类别码：
  R40
• WGK Germany：
  3
• 危险标志：
  GHS08
• 危险性描述：
  H351
• 危险性防范说明：
  P281

反应信息

• 作为反应物：
  描述：

  甘氨酰-L-脯氨酸-4-甲氧基-Β-萘胺 在 dipeptidyl peptidase IV 作用下， 生成 4-甲氧基-2-萘胺 、 甘油-L-脯氨酸
  参考文献：
  名称：

  Mittal, Ashwani; Khurana, Shiwani; Sadana, Rachna, Journal of the Indian Chemical Society, 2002, vol. 79, # 7, p. 605 - 608

  摘要：

  DOI：

文献信息

• Microorganisms detection methods and the separation of agglutinated microorganisms, and a kit for use therein
  申请人：E-Y LABORATORIES, INC.

  公开号：EP0122023A1

  公开（公告）日：1984-10-17

  A test for the differential detection of suspected N. gonorrhoeae (N.g.) and N. meningitidis (N.m.) in provided by contacting a suspected sample with a lectin, preferably wheat germ agglutinin and either soy bean agglutinin or STA potato lectin. An agglutinin reaction is a positive indication of the presence of such microorganisms. Separate portions of the specimen may be contaced with fast substrates specific for (a) N.g., (b) N.m., and (c) B. catarrhalis. Suitable fast substrates are proline naphthylamide, gamma glutamyl naphthylamide, and glycyl prolyl naphthylamide, respectively, each substituted with an electron donating group at the 4-position, 6-position, or both. Another portion of the specimen may be reacted with a substrate for beta-galactosidase enzyme, a positive reaction being an indication that the specimen contains N.lactimica. Autoagglutination, which could otherwise give a false positive in the lectin test, may be prevented by pretreatment of the specimen with DNA'ase and/or an anhydride such as succinic anhydride.

  一种用于鉴别检测疑似淋球菌（N.g.）和脑膜炎双球菌（N.m.）的检测方法是将疑似样本与凝集素（最好是小麦胚芽凝集素和大豆凝集素或 STA 马铃薯凝集素）接触。凝集素反应是此类微生物存在的阳性指标。标本的不同部分可分别与(a) N.g.、(b) N.m.和(c) B. catarrhalis 的特异性快速底物反应。合适的快速底物分别是脯氨酸萘甲酰胺、γ-谷氨酰萘甲酰胺和甘氨酰脯氨酰萘甲酰胺，每种底物都在 4 位、6 位或两者上被电子捐赠基团取代。标本的另一部分可与β-半乳糖苷酶的底物反应，阳性反应表明标本中含有乳酸奈米卡氏菌。用 DNA'ase 和/或酸酐（如琥珀酸酐）对标本进行预处理，可防止自身凝集，否则会在凝集素检测中出现假阳性。
• Detection of Bacteroides gingivalis
  申请人：THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

  公开号：EP0292708A2

  公开（公告）日：1988-11-30

  The present invention relates to the detection of B. gingivalis by the specific ability of B. gingivalis to hydrolyze N-carbobenzoxy-glycyl-glycyl-L-arginine-B-napthylamide deriva­tives. The present invention also relates to the use of assay systems which inhibit serum amino peptidase and enhance the detection of the B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system inhibits the serum enzyme by the use of a serum aminopeptidase inhibitor which inhibits the activity of serum aminopeptidase to a greater extent than it inhibits the activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system also increases the reliability of detection of the B. gingivalis enzyme by the use of enhancing materials which enhance the enzyme activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase to a greater extent than such materials enhance the enzyme activity of serum aminopeptidase.

  本发明涉及通过牙龈杆菌水解 N-羧基苯氧基-甘氨酰-甘氨酰-L-精氨酰-B-萘酰胺衍生物的特异性能力来检测牙龈杆菌。本发明还涉及抑制血清氨基肽酶并提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶检测能力的检测系统的使用。该检测系统通过使用血清氨基肽酶抑制剂来抑制血清酶，该抑制剂对血清氨基肽酶活性的抑制程度大于对牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶活性的抑制程度。该检测系统还通过使用增强材料提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶的酶活性，其增强程度大于此类材料对血清氨肽酶酶活性的增强程度，从而提高检测牙龈杆菌酶的可靠性。
• DNA coding for prolylendopeptidase
  申请人：CIBA-GEIGY (JAPAN) LIMITED

  公开号：EP0524906A1

  公开（公告）日：1993-01-27

  The invention concerns DNA encoding prolylendopeptidase, hybrid vectors containing such DNA, transformed hosts capable of expressing prolylendopeptidase, a process for the production of prolylendopeptidase comprising the steps of: culturing a host organism transformed with an expression vector comprising a DNA coding for prolylendopeptidase and optionally, recovering the produced prolylendopeptidase; and a process for the production of a C-terminal amidated peptide from two precursors thereof, comprising the steps of: placing the two precursors in contact with a prolylendopeptidase in a medium to convert the precursor peptides to the C-terminal amidated peptide, and recovering the resulting C-terminal amidated peptide.

  本发明涉及编码脯氨酰内酯肽酶的 DNA、含有这种 DNA 的杂交载体、能够表达脯氨酰内酯肽酶的转化宿主、生产脯氨酰内酯肽酶的工艺，包括以下步骤： 1：培养用包含编码脯氨内酯肽酶的 DNA 的表达载体转化的宿主生物，并选择性地回收所产生的脯氨内酯肽酶；以及用两种前体生产 C 端酰胺化肽的工艺，包括以下步骤：将两种前体与培养基中的脯氨内酯肽酶接触，使前体肽转化为 C 端酰胺化肽，并回收所产生的 C 端酰胺化肽。
• Prolylendopeptidase from Flavobacterium meningosepticum
  申请人：Ciba-Geigy Japan Limited

  公开号：EP0967285A1

  公开（公告）日：1999-12-29

  The invention concerns DNA encoding prolylendopeptidase, hybrid vectors containing such DNA, transformed hosts capable of expressing prolylendopeptidase, a process for the production of prolylendopeptidase comprising the steps of: culturing a host organism transformed with an expression vector comprising a DNA coding for prolylendopeptidase and optionally, recovering the produced prolylendopeptidase; and a process for the production of a C-terminal amidated peptide from two precursors thereof, comprising the steps of: placing the two precursors in contact with a prolylendopeptidase in a medium to convert the precursor peptides to the C-terminal amidated peptide, and recovering the resulting C-terminal amidated peptide.

  本发明涉及编码脯氨酰内酯肽酶的 DNA、含有这种 DNA 的杂交载体、能够表达脯氨酰内酯肽酶的转化宿主、生产脯氨酰内酯肽酶的工艺，包括以下步骤： 1：培养用包含编码脯氨内酯肽酶的 DNA 的表达载体转化的宿主生物，并选择性地回收所产生的脯氨内酯肽酶；以及用两种前体生产 C 端酰胺化肽的工艺，包括以下步骤：将两种前体与培养基中的脯氨内酯肽酶接触，使前体肽转化为 C 端酰胺化肽，并回收所产生的 C 端酰胺化肽。
• expression vector for prolylendopeptidase from Flavobacterium meningosepticum
  申请人：Novartis AG

  公开号：EP0967285B1

  公开（公告）日：2007-09-12