7βH-eudesm-2-ene-4α,11-diol | 198994-30-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7βH-eudesm-2-ene-4α,11-diol
• 英文别名: (1R,4aS,7S,8aR)-7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-4,5,6,7,8,8a-hexahydronaphthalen-1-ol
• CAS: 198994-30-8
• 化学式: C₁₅H₂₆O₂
• 分子量: 238.37
• InChiKey: DKOHCEUJTLVCJA-CTHBEMJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7βH-eudesm-2-ene-4α,11-diol 在 Pd/SrCO₃ 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 以100%的产率得到isodonsesquitin A
  参考文献：
  名称：

  Enantioselective Total Syntheses of (−)-7βH-Eudesmane-4α,11-diol and (+)-ent-7βH-Eudesmane-4α,11-diol

  摘要：

  The syntheses of (-)-7 beta H-eudesmane-4 alpha,11-diol (2) and (+)-ent-7 beta H-eudesmane-4 alpha,11-diol (ent-2) were carried out starting from (-)- and (+)-dihydrocarvones. As a result, the structure, including absolute configuration, of the naturally occurring eudesmane-4,11-diol isolated from Pluchea arguta was determined to be (+)-ent-7 beta H-eudesmane-4 alpha,11-diol (ent-2).

  DOI：

  10.1021/np9702906
• 作为产物：
  描述：

  ent-5-hydroxy-10α-eudesm-11-en-3-one 在 盐酸 、 叔丁基过氧化氢 、 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 bis(acetylacetonate)oxovanadium 、 乙醇 、 氨 、 aluminum isopropoxide 、 lithium 、 lithium carbonate 、 间氯过氧苯甲酸 、 lithium bromide 作用下， 以 吡啶 、 甲醇 、 乙醚 、 乙醇 、 氯仿 、 N,N-二甲基甲酰胺 、 甲苯 、 苯 为溶剂， 反应 47.83h， 生成 7βH-eudesm-2-ene-4α,11-diol
  参考文献：
  名称：

  Enantioselective Total Syntheses of (−)-7βH-Eudesmane-4α,11-diol and (+)-ent-7βH-Eudesmane-4α,11-diol

  摘要：

  The syntheses of (-)-7 beta H-eudesmane-4 alpha,11-diol (2) and (+)-ent-7 beta H-eudesmane-4 alpha,11-diol (ent-2) were carried out starting from (-)- and (+)-dihydrocarvones. As a result, the structure, including absolute configuration, of the naturally occurring eudesmane-4,11-diol isolated from Pluchea arguta was determined to be (+)-ent-7 beta H-eudesmane-4 alpha,11-diol (ent-2).

  DOI：

  10.1021/np9702906

文献信息

• Enantioselective Total Syntheses of (−)-7β<i>H</i>-Eudesmane-4α,11-diol and (+)-<i>ent</i>-7β<i>H</i>-Eudesmane-4α,11-diol
  作者：Fumito Shimoma、Hisao Kondo、Saori Yuuya、Toshio Suzuki、Hisahiro Hagiwara、Masayoshi Ando

  DOI：10.1021/np9702906

  日期：1998.1.1

  The syntheses of (-)-7 beta H-eudesmane-4 alpha,11-diol (2) and (+)-ent-7 beta H-eudesmane-4 alpha,11-diol (ent-2) were carried out starting from (-)- and (+)-dihydrocarvones. As a result, the structure, including absolute configuration, of the naturally occurring eudesmane-4,11-diol isolated from Pluchea arguta was determined to be (+)-ent-7 beta H-eudesmane-4 alpha,11-diol (ent-2).