阿罗糖 | 7635-11-2

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 阿罗糖
• 中文别名: L-阿洛糖；L（-）-阿洛糖；L(-)-阿罗糖
• 英文名称: L-allose
• 英文别名: beta-L-allose；(2S,3S,4S,5S)-2,3,4,5,6-pentahydroxyhexanal
• CAS: 7635-11-2
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: GZCGUPFRVQAUEE-MOJAZDJTSA-N

物化性质

• 熔点：
  127-129 °C
• 沸点：
  232.96°C (rough estimate)
• 密度：
  1.581
• 稳定性/保质期：
  <b><p></p></b>

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  29400090
• 储存条件：
  -20°C

SDS

Name:	l-(-)-Allose 99% Material Safety Data Sheet
Synonym:	None
CAS:	7635-11-2

Section 1 - Chemical Product MSDS Name:l-(-)-Allose 99% Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7635-11-2	L-(-)-Allose, 99%	99%	231-565-3

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
No information regarding eye irritation and other potential effects was found.
Skin:
Non-irritating to the skin.
Ingestion:
Expected to be a low ingestion hazard.
Inhalation:
No hazard expected in normal industrial use.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.
Skin:
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Ingestion:
Wash mouth out with water. Get medical aid if irritation or symptoms occur.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Good general ventilation should be sufficient to control airborne levels.
Exposure Limits CAS# 7635-11-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 127 - 129 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H12O6
Molecular Weight: 180.16

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7635-11-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-(-)-Allose, 99% - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 7635-11-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 7635-11-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7635-11-2 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

L-阿洛糖是一种生物化学试剂，可用于生命科学相关研究中的生物材料或有机化合物。

反应信息

• 作为反应物：
  描述：

  阿罗糖 生成 L-glucose acetate
  参考文献：
  名称：

  KO, SOO Y.;LEE, ALBERT W. M.;MASAMUNE, SATORU;REED, LAWRENCE A. (III);SHA+, TETRAHEDRON, 46,(1990) N, C. 245-264

  摘要：

  DOI：
• 作为产物：
  描述：

  L-铝离子-1,4-内酯 在 sodium amalgam 、 硫酸 、 水 作用下， 生成 阿罗糖
  参考文献：
  名称：

  The Preparation of Two New Crystalline Aldohexoses, l-Allose and l-Altrose, from l-Ribose by the Cyanohydrin Reaction^1,2,3

  摘要：

  DOI：

  10.1021/ja01320a048

文献信息

• &amp;alpha;-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of &lt;i&gt;Momordica charantia&lt;/i&gt;
  作者：Nguyen Xuan Nhiem、Phan Van Kiem、Chau Van Minh、Ninh Khac Ban、Nguyen Xuan Cuong、Nguyen Huu Tung、Le Minh Ha、Do Thi Ha、Bui Huu Tai、Tran Hong Quang、Tran Minh Ngoc、Young-In Kwon、Hae-Dong Jang、Young Ho Kim

  DOI：10.1248/cpb.58.720

  日期：——

  Fourteen cucurbitane-type triterpene glycosides (1-14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A-C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for alpha-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against alpha-glucosidase

  从苦瓜果实的甲醇提取物中分离出十四种葫芦烷型三萜糖苷（1-14），其中包括三种新化合物，苦瓜甙AC（1、5、6）。通过化学和光谱方法阐明了它们的结构。评价所有分离的化合物的α-葡萄糖苷酶抑制作用。其中12和13显示出对α-葡萄糖苷酶的中等抑制活性。而2、3、6-11和14的抑制活性较弱，而1、4和5则无活性。
• Method of Controlling the Proliferation of Vascular Endothelial Cells and Inhibiting Lumen Formation
  申请人：Tokuda Masaaki

  公开号：US20080306011A1

  公开（公告）日：2008-12-11

  [PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. [MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

  [问题]：寻找一种具有抑制血管内皮细胞增殖和腔形成作用的特定稀有糖，并利用这些作用。提供这种稀有糖作为预防/治疗具有血管生成的疾病、化妆品或功能性食品。 [解决问题的方法]：使用D-甘露糖、D-异洛糖、2-脱氧-D-葡萄糖、3-脱氧-D-葡萄糖、L-山梨糖、2-脱氧-D-核糖和/或2-脱氧-L-核糖的血管内皮细胞增殖控制作用，来控制血管内皮细胞的增殖。使用D-异洛糖、D-阿鲁糖、D-古洛糖、D-他洛糖、L-异洛糖、2-脱氧-D-葡萄糖、3-脱氧-D-葡萄糖、D-核糖、L-核糖、2-脱氧-D-核糖和/或2-脱氧-L-核糖的血管内皮细胞腔形成抑制作用，来抑制血管内皮细胞的腔形成。
• METHOD OF CONTROLLING THE PROLIFERATION OF VASCULAR ENDOTHELIAL CELLS AND INHIBITING LUMEN FORMATION
  申请人：Tokuda Masaaki

  公开号：US20100222285A1

  公开（公告）日：2010-09-02

  A specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation is disclosed. This rare sugar is provided as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. The proliferation of vascular endothelial cells is controlled utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. Lumen formation of vascular endothelial cells is inhibited by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-glucose, D-talose, L-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

  本文披露了一种特定的罕见糖，具有抑制血管内皮细胞增殖和腔形成的作用。该罕见糖可作为预防/治疗血管生成相关疾病、化妆品或功能性食品提供。利用D-甘露糖、D-异鼠李糖、2-去氧-D-葡萄糖、3-去氧-D-葡萄糖、L-山梨糖、2-去氧-D-核糖和/或2-去氧-L-核糖的血管内皮细胞增殖控制作用来控制血管内皮细胞的增殖。利用D-异葡萄糖、D-海藻糖、D-葡萄糖、D-赖糖、L-异鼠李糖、2-去氧-D-葡萄糖、3-去氧-D-葡萄糖、D-核糖、L-核糖、2-去氧-D-核糖和/或2-去氧-L-核糖的血管内皮细胞腔形成抑制作用来抑制血管内皮细胞的腔形成。
• Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
  申请人：ENGENE, INC.

  公开号：US10456481B2

  公开（公告）日：2019-10-29

  Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.

  本文提供了壳聚糖衍生物纳米粒子，包括用阳离子氨基酸和亲水多元醇官能化的壳聚糖；以及制造和使用这种纳米粒子的方法，例如用于体内基因递送。
• Diagnosis and treatment of neonatal encephalopathy
  申请人：InfanDx AG

  公开号：US10514383B2

  公开（公告）日：2019-12-24

  Metabolites and signatures (panels) of metabolites are applicable as biomarkers in clinical diagnosis, in particular for neonatal encephalopathy. They are useful tools in differential clinical diagnosis for early detection of brain injury, determination of brain areas affected by the insults and prediction of adverse neurological outcome and may also be applied in diagnosing disease progression and treatment effect. An in vitro method for predicting the likelihood of neonatal encephalopathy of distinct brain areas, identification of affected brain area(s) of neonatal encephalopathy and risk of brain damage and prognosis and neurological outcome due to identification of the type and extent of damage of distinct brain tissues, in particular of hippocampus and/or basal ganglia, is provided.

  代谢物和代谢物特征（组）可作为生物标记物用于临床诊断，尤其是新生儿脑病的诊断。它们是临床鉴别诊断的有用工具，可用于早期发现脑损伤、确定受损伤影响的脑区和预测不良神经系统结果，还可用于诊断疾病进展和治疗效果。本研究提供了一种体外方法，用于预测不同脑区发生新生儿脑病的可能性、确定新生儿脑病的受影响脑区、脑损伤风险以及由于确定不同脑组织（特别是海马和/或基底节）的损伤类型和程度而导致的预后和神经系统结局。