3-(3-羟基-4-甲基-苯基)-戊烷-2,4-二酮 | 100117-67-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3-(3-羟基-4-甲基-苯基)-戊烷-2,4-二酮
• 英文名称: 3-(3-hydroxy-4-methyl-phenyl)-pentane-2,4-dione
• 英文别名: 3-(3-Hydroxy-4-methyl-phenyl)-pentan-2,4-dion；3-(3-Hydroxy-4-methylphenyl)pentane-2,4-dione；3-(3-hydroxy-4-methylphenyl)pentane-2,4-dione
• CAS: 100117-67-7
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: LRUNLFAALBVMQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-羟基-4-甲基-苯基)-戊烷-2,4-二酮 在 乙醇 、 一水合肼 作用下， 生成 5-(3,5-dimethyl-1H-pyrazol-4-yl)-2-methyl-phenol
  参考文献：
  名称：

  Ultrasonographic, Axial, and Peripheral Measurements in Female Patients with Benign Hypermobility Syndrome

  摘要：

  Twenty-five female Caucasians, aged 19-57 years, with the hypermobility syndrome had bone density measurements using established noninvasive techniques such as dual X-ray absorptiometry (DXA), single photon absorptiometry (SPA), heel ultrasound (US), and peripheral computed tomography (pQCT) acquisitions of the radius. As a group, comparisons of the different bone indices with the corresponding age-matched reference population resulted in normal z-scores for the arial densities, however, values for the volumetric total and cortical bone at the radius measured by pQCT were significantly lower than expected (P < 0.0001). Spinal and femoral bone density results were significant after correction for body mass index (BMI). This cross-sectional study shows that the benign hypermobility syndrome patients have lowered t-scores for data reflecting bone structure and bone strength as measured with US and the tomographic technique.

  DOI：

  10.1007/s00223001093
• 作为产物：
  描述：

  6-acetoxy-6-methylcyclohexa-2,4-dienone 、 乙酰丙酮 在 哌啶 作用下， 生成 3-(3-羟基-4-甲基-苯基)-戊烷-2,4-二酮
  参考文献：
  名称：

  Ultrasonographic, Axial, and Peripheral Measurements in Female Patients with Benign Hypermobility Syndrome

  摘要：

  Twenty-five female Caucasians, aged 19-57 years, with the hypermobility syndrome had bone density measurements using established noninvasive techniques such as dual X-ray absorptiometry (DXA), single photon absorptiometry (SPA), heel ultrasound (US), and peripheral computed tomography (pQCT) acquisitions of the radius. As a group, comparisons of the different bone indices with the corresponding age-matched reference population resulted in normal z-scores for the arial densities, however, values for the volumetric total and cortical bone at the radius measured by pQCT were significantly lower than expected (P < 0.0001). Spinal and femoral bone density results were significant after correction for body mass index (BMI). This cross-sectional study shows that the benign hypermobility syndrome patients have lowered t-scores for data reflecting bone structure and bone strength as measured with US and the tomographic technique.

  DOI：

  10.1007/s00223001093

文献信息

• Ultrasonographic, Axial, and Peripheral Measurements in Female Patients with Benign Hypermobility Syndrome
  作者：J. Nijs、E. Van Essche、M. De Munck、J. Dequeker

  DOI：10.1007/s00223001093

  日期：2000.7

  Twenty-five female Caucasians, aged 19-57 years, with the hypermobility syndrome had bone density measurements using established noninvasive techniques such as dual X-ray absorptiometry (DXA), single photon absorptiometry (SPA), heel ultrasound (US), and peripheral computed tomography (pQCT) acquisitions of the radius. As a group, comparisons of the different bone indices with the corresponding age-matched reference population resulted in normal z-scores for the arial densities, however, values for the volumetric total and cortical bone at the radius measured by pQCT were significantly lower than expected (P < 0.0001). Spinal and femoral bone density results were significant after correction for body mass index (BMI). This cross-sectional study shows that the benign hypermobility syndrome patients have lowered t-scores for data reflecting bone structure and bone strength as measured with US and the tomographic technique.