3-(4-甲基苯亚甲基)樟脑 | 36861-47-9

• 物质功能分类: 分析化学 - 标准品 - 分析标准品
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3-(4-甲基苯亚甲基)樟脑
• 中文别名: (±)-1,7,7-三甲基-[(4-甲基苯基)亚甲基]-双环[2,2,1]庚烷-2-酮；(3E)-1,7,7-三甲基-3-[(4-甲基苯基)亚甲基]双环[2.2.1]庚烷-2-酮；3-(4-甲基亚苄基)-d-樟脑；4-甲基苄亚基樟脑；3-(4-甲基苯亚甲基)-樟脑；3-(4-甲基苯亚甲基)樟脑[3-(4-甲基亚苄基)樟脑]；3-(4-甲基苄烯)-樟脑；3-(4-甲基亚苄基)樟脑；4-甲基苯亚甲基樟脑；4-甲基-苯亚甲基-樟脑；(3E)-1,7,7-三甲基-3-[(4-甲基苯基)亚甲基]双环[2.2.1]庚烷-；MBC 95
• 英文名称: 3-(4-methylbenzyliden) camphor
• 英文别名: Eusolex 6300；Enzacamene；3-(4-methylbenzylidene)-d,l-camphor；4′-methylbenzylidene camphor；3-(4-methyl)benzylidene camphor；3-(4-methylbenzylidene)-camphor；4-Methylbenzylidene camphor；1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one
• CAS: 36861-47-9
• 化学式: C₁₈H₂₂O
• 分子量: 254.372
• InChiKey: HEOCBCNFKCOKBX-UHFFFAOYSA-N

物化性质

• 熔点：
  66-68°C
• 沸点：
  198-200 °C
• 密度：
  1.064±0.06 g/cm3(Predicted)
• 溶解度：
  不溶于水； DMSO 中≥10 mg/mL；乙醇中≥111.2 mg/mL
• LogP：
  3.385 (est)
• 稳定性/保质期：
  常规情况下不会分解，没有危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S22,S24/25
• 危险类别码：
  R63
• WGK Germany：
  2,3
• 海关编码：
  2914399000
• 危险品运输编号：
  25kgs
• 包装等级：
  III
• 危险类别：
  9
• 危险性防范说明：
  P273,P281
• 危险性描述：
  H360,H410
• 储存条件：
  密封、阴凉、干燥、通风保存

制备方法与用途

生物活性

4-甲基苯基丙烯基莰烷（4-MBC；Enzacamene）是一种有机樟脑衍生物，广泛应用于化妆品行业，用以保护皮肤免受紫外线的伤害，尤其是紫外线B辐射。

用途

作为一种油溶性UV-B吸收剂，只需少量添加即可显著提高SPF值。此外，它还能作为Parsol 1789的有效光稳定剂。

反应信息

• 作为反应物：
  描述：

  3-(4-甲基苯亚甲基)樟脑 在 硫酸 、 iron phthalocyanine chloride 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 1,7,7-Trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-ol
  参考文献：
  名称：

  Application of a biomimetic sensor based on iron phthalocyanine chloride: 4-methylbenzylidene-camphor detection

  摘要：

  The construction and application of a biomimetic sensor for determination of 4-methylbenzylidene camphor (4-MBC), an ultraviolet (UV) radiation protector, are described. The sensor was prepared by modifying a carbon paste electrode with iron(III) phthalocyanine chloride (FePcCl). Amperometric measurements carried out with the sensor under an applied potential of 0.0 V vs. Ag vertical bar AgCl in a mixture of tetrahydrofuran and 0.1 mol L-1 H2SO4 solution (30:70 volume ratio) showed a linear response range from 1.8x10(-4) to 9.0x10(-4) mol L-1. A detailed selectivity investigation for other nine UV filters was also performed. A sensor response mechanism was proposed and the results for 4-MBC quantification in commercial sunscreens and in water from swimming pools and rivers are presented.

  DOI：

  10.1590/s0103-50532010000700025
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙酰氯 作用下， 生成 3-(4-甲基苯亚甲基)樟脑
  参考文献：
  名称：

  Haller, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1912, vol. 154, p. 744

  摘要：

  DOI：

文献信息

• COMPOSITION CONTAINING A PHENANTHRENOL
  申请人：WILLEMIN Claudie

  公开号：US20090018200A1

  公开（公告）日：2009-01-15

  Novel uses of phenanthrenol compounds for improving the appearance and/or texture of the skin.

  新型苯并酚化合物的应用，用于改善皮肤的外观和/或质地。
• Methyltrialkylsilanes containing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function and photostabilizing methods
  申请人：Richard Herve

  公开号：US20080171802A1

  公开（公告）日：2008-07-17

  Unique photoprotective compositions contain novel methyltrialkylsilanes bearing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function, useful as sunscreens that are active in the field of UV radiation and also useful in methods for photostabilizing synthetic polymers or glasses.

  独特的光保护组合物包含新型的甲基三烷基硅烷，带有肉桂酸酯、肉桂酰胺、苯甲酰丙酰胺或苯甲酰丙酸酯功能，可用作活性紫外线防晒剂，并且在合成聚合物或玻璃的光稳定方法中也有用。
• COSMETIC OR DERMATOLOGICAL COMPOSITION IN THE FORM OF AN OIL-IN-WATER OR WATER-IN-OIL-IN-WATER EMULSION COMPRISING A HEAT-INDUCED GELLING POLYMER, A WATER-MISCIBLE VOLATILE ORGANIC SOLVENT AND AN ORGANIC UV-SCREENING AGENT
  申请人：Candau Didier

  公开号：US20100104520A1

  公开（公告）日：2010-04-29

  Cosmetic or dermatological composition in the form of an oil-in-water or water-in-oil-in-water emulsion comprising a heat-induced gelling polymer, a water-miscible volatile organic solvent and an organic UV-screening agent The present invention relates to a cosmetic or dermatological composition in the form of an oil-in-water emulsion or of water-in-oil-in-water multiple emulsion, characterized in that it comprises, in a physiologically acceptable medium: a) at least one continuous aqueous phase, b) at least one heat-induced gelling polymer, c) at least one water-miscible volatile solvent in a concentration ranging from 1% to 20% by weight relative to the total weight of the composition, d) at least one organic UV-screening agent. The invention relates to the use of at least one heat-induced gelling polymer and of at least one water-miscible volatile organic solvent in a cosmetic composition in the form of an oil-in-water emulsion or a water-in-oil-in-water multiple emulsion containing, in a physiologically acceptable medium, at least one agent for absorbing UV radiation, for the purpose of reducing or eliminating the effect of migration of the composition outside the application area. The invention also relates to the use of at least one heat-induced gelling polymer and of at least one water-miscible volatile organic solvent in a cosmetic composition in the form of an oil-in-water emulsion or a water-in-oil-in-water multiple emulsion containing, in a physiologically acceptable medium, at least one agent for absorbing UV radiation, for the purpose of improving the cosmetic pleasantness and the comfort of use; and more particularly for improving the spreading, improving the ocular comfort and reducing the effect of running of the composition on keratin materials.

  一种油水乳液或水油水复合乳液形式的化妆品或皮肤科学组合物，其包含一种热诱导凝胶聚合物、一种水溶性挥发性有机溶剂和一种有机紫外线筛选剂。本发明涉及一种化妆品或皮肤科学组合物，其为油水乳液或水油水复合乳液形式，其特征在于它包括以下生理可接受介质：a)至少一种连续水相，b)至少一种热诱导凝胶聚合物，c)在相对于组合物总重量的1％至20％的浓度范围内的至少一种水溶性挥发性溶剂，d)至少一种有机紫外线筛选剂。本发明涉及在化妆品或皮肤科学组合物中使用至少一种热诱导凝胶聚合物和至少一种水溶性挥发性有机溶剂，其为油水乳液或水油水复合乳液形式，包含至少一种吸收紫外线辐射的剂量，以减少或消除组合物在应用区域以外的迁移效应。本发明还涉及在化妆品或皮肤科学组合物中使用至少一种热诱导凝胶聚合物和至少一种水溶性挥发性有机溶剂，其为油水乳液或水油水复合乳液形式，包含至少一种吸收紫外线辐射的剂量，以改善化妆品的舒适度和使用感受，尤其是改善扩散性、改善眼部舒适度并减少组合物对角质材料的影响。
• PHOTOPROTECTIVE COMPOSITION CONTAINING AN UNMODIFIED GELLING STARCH AND POLYAMIDE PARTICLES
  申请人：Chevalier Cyril

  公开号：US20110256192A1

  公开（公告）日：2011-10-20

  The present invention relates to a composition intended for protecting the skin and/or hair against ultraviolet radiation, characterized by the fact that it comprises, in a cosmetically acceptable support containing at least one aqueous phase, at least: (a) a photoprotective system capable of screening out UV radiation; (b) at least one gelling starch that is not modified by a chemical or physical process; and (c) polyamide particles, in particular polyamide PA-12 or polyamide PA-6 particles. The present invention also relates to the use of the combination of at least one gelling starch that is not modified by a chemical or physical process and polyamide particles in a composition comprising, in a cosmetically acceptable support comprising at least one aqueous phase, at least one photoprotective system capable of screening out UV radiation, for the purpose of improving the cosmetic properties after application, especially the non-tacky effect, non-greasy effect, non-shiny effect and/or the absence of residual film.

  本发明涉及一种用于保护皮肤和/或头发免受紫外线辐射的组合物，其特征在于它包含以下成分，至少在一个含有至少一个水相的化妆品可接受载体中：（a）一种光保护系统，能够筛选出紫外线辐射；（b）至少一种未经化学或物理处理的胶化淀粉；和（c）聚酰胺颗粒，特别是聚酰胺PA-12或聚酰胺PA-6颗粒。本发明还涉及至少一种未经化学或物理处理的胶化淀粉和聚酰胺颗粒的组合物在一种化妆品可接受载体中的应用，所述载体中包含至少一个水相，其中还包括至少一种能够筛选出紫外线辐射的光保护系统，旨在改善应用后的化妆品性质，特别是无粘性、不油腻、不闪光和/或无残留膜的效果。
• FLUID AQUEOUS ANTISUN COMPOSITION BASED ON A SUPERABSORBENT POLYMER AND A CROSSLINKED COPOLYMER OF METHACRYLIC ACID AND OF A C1-C4 ALKYL ACRYLATE
  申请人：Gaudry Anne-Laure

  公开号：US20140030297A1

  公开（公告）日：2014-01-30

  The present invention relates to a fluid composition, characterized in that it comprises, in a cosmetically acceptable aqueous support: (a) at least one fatty phase; (b) a photoprotective system capable of screening out UV radiation; (c) at least one superabsorbent polymer; (d) at least one crosslinked copolymer of methacrylic acid and of a C 1 -C 4 alkyl acrylate. Another subject of the present invention lies in the use of the combination of a superabsorbent polymer and of a crosslinked copolymer of methacrylic acid and of an alkyl acrylate in a fluid composition comprising, in a cosmetically acceptable aqueous support, at least one photoprotective system capable of screening out UV radiation, as a freshness agent and/or as a stabilizer for the composition.

  本发明涉及一种流体组合物，其特征在于它包括以下成分，以在化妆品可接受的水基体系中使用：(a) 至少一种脂肪相；(b) 一种光保护系统，能够筛选出紫外线辐射；(c) 至少一种超吸水性聚合物；(d) 至少一种甲基丙烯酸和C1-C4烷基丙烯酸酯的交联共聚物。本发明的另一个对象在于使用超吸水性聚合物和甲基丙烯酸和烷基丙烯酸酯的交联共聚物的组合物，在化妆品可接受的水基体系中包括至少一种光保护系统，作为清新剂和/或组合物的稳定剂。