3-(4-羟基苯基)乳酸乙酯 | 62517-34-4

• 物质功能分类: 天然产物 - 苯丙素
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-(4-羟基苯基)乳酸乙酯
• 英文名称: ethyl 2-hydroxy-3-(4-hydroxyphenyl)propionate
• 英文别名: ethyl 3-(4-hydroxyphenyl)lactate；ethyl p-hydroxyphenyllactate；latifolicin B；ethyl 3-(4-hydroxyphenyl)-2-hydroxy propanoate；ethyl 2-hydroxy-3-(4-hydroxyphenyl)propanoate
• CAS: 62517-34-4
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: MPPNCBJETJUYAO-UHFFFAOYSA-N

物化性质

• 沸点：
  367.0±27.0 °C(Predicted)
• 密度：
  1.225±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-羟基苯基)乳酸乙酯 在 potassium carbonate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 20.0h， 生成 2-phenoxy-3-(4-benzyloxyphenyl)propionic acid ethyl ester
  参考文献：
  名称：

  Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

  摘要：

  We previously reported the identification of novel oximes having 5-benzyl-2,4-thiazolidinedione with anti hyperglycemic activity. We now report the synthesis and biological activity of a novel series of oximes and amides having alpha-substituted-beta-phenylpropionic acids. In this series, we obtained potent PPARalpha/gamma dual agonist (S)-9d, with which activation of PPARalpha and PPARgamma was considerably more potent than that of the reference compounds GW9578 22 and rosiglitazone 3, respectively. This means (S)-9d is of the strongest class of PPARalpha/gamma dual agonists. In the course of this study, we also obtained 8h, which indicated potent plasma glucose lowering effect in spite of weak PPARalpha/gamma agonistic activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.01.048
• 作为产物：
  描述：

  D,L 3-(4-hydroxyphenyl) lactic acid hydrate 在 盐酸 作用下， 以 乙醇 为溶剂， 以0.54 g (2.57 mmol,94%)的产率得到3-(4-羟基苯基)乳酸乙酯
  参考文献：
  名称：

  Benzo-fused lactams that promote the release of growth hormone

  摘要：

  已披露了一些新型化合物，被确定为苯并咪唑内酰胺，可促进人类和动物体内生长激素的释放。这种特性可以用于促进食用动物的生长，使可食用肉制品的生产更加高效，在人类身上，可以增加那些缺乏正常分泌天然生长激素的人的身高。还披露了含有苯并咪唑内酰胺作为活性成分的促生长组合物。

  公开号：

  US05206235A1

文献信息

• Amidocarboxylic acid derivatives
  申请人：Sankyo Company, Limited

  公开号：US06528525B1

  公开（公告）日：2003-03-04

  Amidocarboxylic acid derivatives of the formula: wherein R1 represents a hydrogen atom, etc.; R2 represents an alkylene group; R3 represents a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; X represents a substituted or unsubstituted aryl group, etc.,; Y represents an oxygen atom, etc.; Z represents an alkylene group, etc.; and W represents an alkyl group, etc.; and pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof are useful as the active ingredient of pharmaceutical compositions. They may be used to treat specified diseases, including diabetes mellitus, hyperlipemia, arteriosclerosis, hypertension, etc.

  公式为：其中R1代表氢原子，等等；R2代表烷基团；R3代表氢原子，等等；R4代表氢原子，等等；X代表取代或未取代的芳基团，等等；Y代表氧原子，等等；Z代表烷基团，等等；W代表烷基团，等等；以及其药理学上可接受的盐和药理学上可接受的酯作为药物组合物的活性成分是有用的。它们可用于治疗特定疾病，包括糖尿病、高脂血症、动脉硬化、高血压等。
• Process for production of phenyllactic acid derivative
  申请人：Nitto Chemical Industry Co., Ltd.

  公开号：US05684186A1

  公开（公告）日：1997-11-04

  A process for producing a phenyllactic acid derivative comprises hydrogenating a phenylpyruvic acid derivative in the presence of a catalyst containing at least one element selected from the Group VIII elements of the periodic table. The process provides a phenyllactic acid derivative useful as an intermediate in the production of pharmaceuticals and agricultural chemicals. The process uses as a starting material a phenylpyruvic acid derivative which is easily synthesized. The process is simpler in operation and provides a higher yield than conventional processes.

  生产苯丙乳酸衍生物的工艺包括在含有至少一种来自周期表第VIII族元素的催化剂的存在下，氢化苯丙酮酸衍生物。该工艺提供了一种苯丙乳酸衍生物，可用作制药和农药化学品生产中的中间体。该工艺使用易于合成的苯丙酮酸衍生物作为起始物质。该工艺操作简单，并且比传统工艺提供更高的产量。
• Tricyclic compounds and their use in medicine process for their
  申请人：Redd's Research Foundation

  公开号：US06054453A1

  公开（公告）日：2000-04-25

  Novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. ##STR1## The compounds have hypolipidemic, antihyperglycemic uses.

  小说.β.-芳基-.α.-氧基取代的烷基羧酸的化学式(I)及含有它们的组合物。##STR1## 这些化合物具有降脂、抗高血糖的用途。
• Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Research Foundation

  公开号：US06440961B1

  公开（公告）日：2002-08-27

  A compound of formula (1) it derivatives, its analogs, its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts, or its pharmaceutically acceptable solvates, processes for its preparation and methods of use thereof.

  式（1）化合物及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐或药学上可接受的溶剂，其制备方法以及使用方法。
• [EN] NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES TRICYCLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CES DERNIERS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：WO1999019313A1

  公开（公告）日：1999-04-22

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.(FR) La présente invention concerne de nouveaux acides alkylcarboxyliques $g(b)-aryl-$g(a)-oxysubstitués répondant à la formule (I) et des compositions les contenant. Ces composés sont utilisés comme agents hypolipémiants et antihyperglycémiants.

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses. (中文翻译) 新型的公式（I）中的$g(b)-芳基-$g(a)-氧代取代烷基羧酸和含有它们的组合物。这些化合物具有降血脂和抗高血糖的作用。