甲基纤维素 | 9004-67-5

• 物质功能分类: 原料药 - 专科用药 - 眼科用药
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甲基纤维素
• 中文别名: 纤维素甲醚；甲基纤维素(药用)；MC
• 英文名称: Methylcellulose
• 英文别名: 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane
• CAS: 9004-67-5
• 化学式: C₂₀H₃₈O₁₁
• 分子量: 454.5
• InChiKey: YLGXILFCIXHCMC-UHFFFAOYSA-N

物化性质

• 熔点：
  290-305 °C
• 密度：
  1.01 g/cm3(Temp: 70 °C)
• 溶解度：
  几乎不溶于热水、丙酮、无水乙醇和甲苯。它溶于冷水，形成胶体溶液。
• 介电常数：
  3.0（Ambient）
• 稳定性/保质期：
  1. 常温常压下不稳定，应避免潮湿、明火及高温环境。产品的性质与取代度有关，在取代度相同时，取代基分布越均匀的产品通常聚合度较低，溶解性较好。 当加热时，其黏度最初会随温度升高而降低，但达到某一温度后会急剧变化并发生凝胶化现象。无毒、无味，具有优良的保湿性、分散性和稳定性。

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  11

ADMET

毒理性

• 相互作用

.../甲基纤维素/被发现与几种化合物相互作用，大致按照以下降序：对羟基苯甲酸，对氨基苯甲酸，甲基对羟基苯甲酸酯，丙基对羟基苯甲酸酯和丁基对羟基苯甲酸酯。

.../METHYLCELLULOSE/ WAS FOUND TO INTERACT WITH SEVERAL COMPD IN ROUGHLY FOLLOWING DECR ORDER: P-HYDROXYBENZOIC ACID, P-AMINOBENZOIC ACID, METHYL P-HYDROXYBENZOATE, PROPYL P-HYDROXYBENZOATE, & BUTYL P-HYDROXYBENZOATE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫并视需要治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污染后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。开始静脉输液，使用D5W（5%葡萄糖溶液）/SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎输液。注意液体过载的迹象。使用地西泮（安定）治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。/毒药A和B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

甲基硅藻酸钠片剂在服用时如果水量有限，可能会导致粪便嵌塞和肠梗阻。

...TABLETS OF METHYLCELLULOSE HAVE CAUSED FECAL IMPACTION & INTESTINAL OBSTRUCTION WHEN TAKEN WITH LIMITED AMT OF WATER.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

这个代理对眼组织无刺激性，可以长时间使用而不会对眼睛造成损害。但如果允许过量的溶液在上眼睑上干燥，可能会引起不适。

THIS AGENT IS NONIRRITATING TO OCULAR TISSUE & CAN BE USED FOR PROLONGED PERIODS WITHOUT CAUSING DAMAGE TO EYE. IT MAY CAUSE DISCOMFORT IF EXCESS SOLN IS ALLOWED TO DRY ON UPPER LID.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

据报道，当甲基纤维素通过静脉给药给狗和兔子时，除了对循环血液的影响外，身体无法降解该物质导致其在肝脏、脾脏、淋巴结、肾脏和血管壁中滞留和积聚。

... Reported that when methylcellulose was given iv to dog and rabbit ... aside from effect upon circulating blood, inability of body to degrade substance led to its retention & accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当吞咽时，它们不会被显著吸收，并在粪便中保持不变。/纤维素醚/

When swallowed they are not absorbed to any appreciable degree and appear unchanged in feces. /Cellulose ethers/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• TSCA：
  Yes
• 安全说明：
  S24/25
• WGK Germany：
  1,3
• 海关编码：
  39129000
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

根据您提供的信息,这里对甲基纤维素的生产方法及主要用途进行了总结:

1. 生产方法:

• 由碱处理后的纤维素与氯甲烷反应制得。
• 主要原料为木浆或棉浆。
• 反应过程包括:浸泡、撕碎、老化、醚化(在氯甲烷中于60-70℃反应5小时)、后处理(热水洗涤、中和、脱水干燥等)。

2. 主要用途:

• 增稠剂:用于食品、化妆品等行业。
• 稳定剂:用于制药、纺织等领域。
• 乳化剂:用于化妆品、涂料等产品。
• 分散剂:用于染料、颜料等的分散。
• 赋形剂:如您提到在医药工业中用作保护胶体和分散剂。

3. 其他应用:

• 作为骨髓细胞培养基
• 用于PFGE(脉场凝胶电泳)技术中
• 制备合成树脂、涂料等

4. 配伍禁忌:与某些物质如酚、氯甲苯酚等可能发生反应,需要避免。

5. 特性:

• 在水中易溶
• 抗盐性好
• 低灰分含量
• 具有表面活性作用

希望这些信息对您有所帮助。如果还有其他问题,请随时提问。

文献信息

• Systems and methods for sequencing carbohydrates
  申请人：Reinhold Vernon N.

  公开号：US20080167824A1

  公开（公告）日：2008-07-10

  In many aspects, the systems and methods of the invention are directed to sequencing of carbohydrates by mass spectrometry using computational approaches. The systems and methods utilize data derived from sequential mass spectrometry, in which a carbohydrate is fragmented to form products, each of which may then be fragmented further, gradually disassembling the carbohydrate. The systems and methods according to the principles of the invention resolve the tree-like structure of the original carbohydrate by examining the different ways in which disassembly occurs and then applying a set of inference rules that are at least based on mathematical constraints imposed on such tree-like structures.
• HYDROPHILIC MONOLAYER FILMS
  申请人：MITSUI CHEMICALS, INC.

  公开号：US20170044393A1

  公开（公告）日：2017-02-16

  The invention provides monolayer films excellent in hydrophilicity and transparency which include a crosslinked resin having a surface enriched with hydrophilic groups, and materials which exhibit excellent properties such as hydrophilicity, antifogging properties and antifouling properties by virtue of having the above monolayer films. A monolayer film is fabricated which includes a crosslinked resin obtained by polymerizing a composition including a compound (I) having an anionic hydrophilic group and a functional group with a polymerizable carbon-carbon double bond, and a compound (II) having three or more hydroxyl groups and three or more functional groups with a polymerizable carbon-carbon double bond, the monolayer film having a gradient (Sa/Da) of not less than 1.1 wherein Sa is the surface concentration of the anionic hydrophilic groups in the monolayer film, and Da is the deep concentration of the hydrophilic groups at ½ of the thickness of the monolayer film.
• US9976049B2
  申请人：——

  公开号：US9976049B2

  公开（公告）日：2018-05-22
• [EN] SYSTEMS AND METHODS FOR SEQUENCING CARBOHYDRATES<br/>[FR] SYSTÈMES ET PROCÉDÉS POUR LE SÉQUENÇAGE DE GLUCIDES
  申请人：UNIV NEW HAMPSHIRE

  公开号：WO2008027599A2

  公开（公告）日：2008-03-06

  [EN] In many aspects, the systems and methods of the invention are directed to sequencing of carbohydrates by mass spectrometry using computational approaches. The systems and methods utilize data derived from sequential mass spectrometry, in which a carbohydrate is fragmented to form products, each of which may then be fragmented further, gradually disassembling the carbohydrate. The systems and methods according to the principles of the invention resolve the tree-like structure of the original carbohydrate by examining the different ways in which disassembly occurs and then applying a set of inference rules that are at least based on mathematical constraints imposed on such tree-like structures.
  [FR] Dans beaucoup d'aspects, les systèmes et les procédés de l'invention se rapportent au séquençage de glucides par spectrométrie de masse réalisées au moyen d'approches par ordinateur. Les systèmes et les procédés utilisent des données provenant d'une spectrométrie de masse séquentielle dans laquelle un glucide est fragmenté pour former des produits, dont chacun peut être fragmenté à nouveau, décomposant progressivement le glucide. Les systèmes et les procédés selon les principes de l'invention résolvent la structure arborescente du glucide initial par examen des différentes manières dans lesquelles une décomposition se produit, puis par application d'un ensemble de règles de déduction s'appuyant au moins sur des contraintes mathématiques imposées sur de telles structures arborescentes.

表征谱图