8-formyl-3-phenyl-2H-chromen-2-one | 212515-91-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 8-formyl-3-phenyl-2H-chromen-2-one
• CAS: 212515-91-8
• 化学式: C₁₆H₁₀O₃
• 分子量: 250.254
• InChiKey: AFFPPZCVJYUVIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.28
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  乙酰乙酸乙酯 、 8-formyl-3-phenyl-2H-chromen-2-one 在 氨 作用下， 以 异丙醇 为溶剂， 反应 30.0h， 以50%的产率得到2,6-Dimethyl-4-(2-oxo-3-phenyl-2H-chromen-8-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Coumarin 1,4-Dihydropyridine Derivatives

  摘要：

  A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompained by a decrease of the activity on myocardial and vascular parameters, but the synthesized compounds showed selective inhibiting effects on cardiac contractility and frequency. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00037-6
• 作为产物：
  描述：

  8-甲基-3-苯基色烯-2-酮 在 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 、 乌洛托品 作用下， 以 四氯化碳 为溶剂， 反应 8.25h， 生成 8-formyl-3-phenyl-2H-chromen-2-one
  参考文献：
  名称：

  Coumarin 1,4-Dihydropyridine Derivatives

  摘要：

  A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompained by a decrease of the activity on myocardial and vascular parameters, but the synthesized compounds showed selective inhibiting effects on cardiac contractility and frequency. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00037-6