3-溴苯丙氨酸 | 30163-20-3

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 苯丙氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-溴苯丙氨酸
• 中文别名: 3-溴-DL-苯丙氨酸
• 英文名称: 2-amino-3-(3-bromophenyl)propanoic acid
• 英文别名: 3-bromo-DL-phenylalanine；2-azaniumyl-3-(3-bromophenyl)propanoate
• CAS: 30163-20-3
• 化学式: C₉H₁₀BrNO₂
• 分子量: 244.088
• InChiKey: GDMOHOYNMWWBAU-UHFFFAOYSA-N

物化性质

• 沸点：
  368.4±32.0 °C(Predicted)
• 密度：
  1.588±0.06 g/cm3(Predicted)
• 溶解度：
  酸水溶液（少量溶解）、碱水溶液（少量溶解）、甲醇（少量，加热）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: DL-3-Bromophenylalanine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: DL-3-Bromophenylalanine
CAS number: 30163-20-3

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H10BrNO2
Molecular weight: 244.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-溴苯丙氨酸 在 decarboxylase from Enterococcus faecium 、 sodium citrate 作用下， 反应 22.0h， 以81%的产率得到3-溴苯乙胺
  参考文献：
  名称：

  肉桂酸双酶法转化为2-芳基乙胺

  摘要：

  羧酸（例如丙烯酸）向胺的转化是在合成有机化学中仍然具有挑战性的转化。尽管在自然代谢途径中普遍存在相似的部分，但出于这一目的，生物催化途径似乎已被忽略。本文中，我们介绍了一种双酶体系的概念和优化方法，它允许从容易获得的环取代肉桂酸合成β-苯乙胺衍生物。在通过两步方法表征了反应的两个部分之后，优化了允许单罐生物转化的一组条件。可逆的脱氨酶和不可逆的脱羧酶的组合，对串联的氨基酸中间体均具有特异性，

  DOI：

  10.1002/cctc.201902128
• 作为产物：
  描述：

  3-溴苄溴 在 盐酸 、 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 21.0h， 生成 3-溴苯丙氨酸
  参考文献：
  名称：

  Hydroxyethylene Sulfones as a New Scaffold To Address Aspartic Proteases:  Design, Synthesis, and Structural Characterization

  摘要：

  Hydroxyethylene sulfones were developed as novel scaffolds against aspartyl proteases. A diastereoselective synthesis has been established to introduce the required side chain decoration with desired stereochemistry. Depending on the substitution of the hydroxyethylene-sulfone core, micro- to submicromolar inhibition of HIV-1 protease is achieved for the S-configuration at P, and R-configuration at the hydroxy-group-bearing backbone atom. This stereochemical preference is consistent with the S,R configuration of amprenavir. The racemic mixture of the most potent derivative (K-i = 80 nM) was separated by chiral HPLC, revealing the S,R,S-enantiomer to be more active (K-i = 45 nM). Docking studies suggested this isomer as the more active one. The subsequently determined crystal structure with HIV-1 protease, cocrystallized from a racemic mixture, exclusively reveals the S,R,S-enantiomer accommodated to the binding pocket. The transition state mimicking hydroxy group of the inhibitor is centered between both catalytic aspartates, while either its carbonyl or sulfonyl group forms H-bonds to the structurally conserved water mediating interactions between ligand and Ile50NH/Ile50NH' of both flaps. Biological testing of the stereoisomeric hydroxyethylene sulfones against cathepsin D and beta-secretase did not reveal significant inhibition. Most likely, the latter proteases require inverted configuration at the hydroxy group.

  DOI：

  10.1021/jm050224y

文献信息

• A novel phenylalanine ammonia-lyase from Pseudozyma antarctica for stereoselective biotransformations of unnatural amino acids
  作者：Andrea Varga、Pál Csuka、Orlavanah Sonesouphap、Gergely Bánóczi、Monica Ioana Toşa、Gabriel Katona、Zsófia Molnár、László Csaba Bencze、László Poppe、Csaba Paizs

  DOI：10.1016/j.cattod.2020.04.002

  日期：2021.4

  derivatives (rac-1a-s) by enzymatic ammonia elimination and also in the enantiotope selective ammonia addition reactions to cinnamic acid derivatives (2a-s). The enantiotope selectivity of PzaPAL with o-, m-, p-fluoro-, o-, p-chloro- and o-, m-bromo-substituted cinnamic acids proved to be higher than that of PcPAL.

  通过针对已知的PAL序列筛选微生物基因组，鉴定了一种新型的嗜冷酵母南极假单胞菌（PZa PAL）苯丙氨酸解氨酶。与真核生物的已知PAL相比，PZa PAL具有显着不同的底物结合口袋，带有一个延伸的环（长26 aa）连接到活性位点的芳香环结合区域。表征了在大肠杆菌中表达的重组PZa PAL的一般性质，包括该新PAL与1-苯丙氨酸（S）-1a和其他外消旋取代苯丙氨酸rac - 1b-g，k的动力学特征。。在大多数情况下，PZa PAL的营业额明显高于Petroselinum crispum（Pc PAL）的PAL。最后，在外消旋苯丙氨酸衍生物（rac - 1a-s）通过酶促氨消除的动力学拆分以及对映体选择性氨加成肉桂酸衍生物（2a-s）的动力学拆分中，比较了PZa PAL和Pc PAL的生物催化性能。。的enantiotope选择性PZA PAL与ö - ，米- ，p -氟，ø - ，p氯代和ø
• Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines
  作者：Xiangyuan Liu、Yang Liu、Guobi Chai、Baokun Qiao、Xiaowei Zhao、Zhiyong Jiang

  DOI：10.1021/acs.orglett.8b02791

  日期：2018.10.5

  With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox-active esters (RAEs) to isoquinolines has been developed. A variety of prochiral α-aminoalkyl radicals generated from RAEs were successfully introduced

  借助手性磷酸和二氰基吡嗪衍生的生色团（DPZ）光敏剂的双重有机催化体系，并在可见光照射下，将α-氨基酸衍生的氧化还原活性酯（RAE）的对映选择性Minisci型加到异喹啉中已经被开发出来。从RAE产生的各种前手性α-氨基烷基已成功引入异喹啉，以高收率提供了一系列有价值的α-异喹啉取代的手性仲胺，具有良好或优异的对映选择性。
• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：Arimilli N. Murty

  公开号：US20050239054A1

  公开（公告）日：2005-10-27

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种识别含有羧酸酯或磷酸酯基团取代的抗HIV治疗化合物的方法。可以选择使用新型酶GS-7340酯水解酶对这类化合物库进行筛选。还提供了与GS-7340酯水解酶相关的组合物和方法。
• Cobalt-Catalyzed C(sp²)–H Carbonylation of Amino Acids Using Picolinamide as a Traceless Directing Group
  作者：Lukass Lukasevics、Aleksandrs Cizikovs、Liene Grigorjeva

  DOI：10.1021/acs.orglett.1c00660

  日期：2021.4.2

  we report an efficient protocol for the C(sp2)–H carbonylation of amino acid derivatives based on an inexpensive cobalt(II) salt catalyst. Carbonylation was accomplished using picolinamide as a traceless directing group, CO (1 atm) as the carbonyl source, and Co(dpm)2 as the catalyst. A broad range of phenylalanine derivatives bearing diverse functional groups were tolerated. Moreover, the method can

  在此，我们报告了一种基于廉价钴 (II) 盐催化剂的氨基酸衍生物C(sp 2 )-H 羰基化的有效方案。羰基化是使用吡啶甲酰胺作为无痕导向基团、CO (1 atm) 作为羰基源和 Co(dpm) 2作为催化剂来完成的。广泛的带有不同官能团的苯丙氨酸衍生物是可以耐受的。此外，该方法可成功应用于短肽的 C(sp 2 )-H 羰基化，从而允许进行肽后期羰基化。
• α-Chymotrypsin-catalysed peptide synthesis via the kinetically controlled approach using activated esters as acyl donors in organic solvents with low water content: incorporation of non-protein amino acids into peptides
  作者：Toshifumi Miyazawa、Shin’ichi Nakajo、Miyako Nishikawa、Kazumi Hamahara、Kiwamu Imagawa、Eiichi Ensatsu、Ryoji Yanagihara、Takashi Yamada

  DOI：10.1039/b004183l

  日期：——

  α-chymotrypsin-catalysed peptide synthesis via the kinetically controlled approach is greatly improved by the use of activated esters such as the 2,2,2-trifluoroethyl ester as acyl donors instead of the conventional methyl ester in organic solvents such as acetonitrile with low water content. This approach is useful for the incorporation of non-protein amino acids such as halogenophenylalanines into peptides.

  在α-胰凝乳蛋白酶催化下的偶联效率 肽通过使用活化的方法，通过动力学控制方法的合成得到了极大的改善酯类 例如2,2,2-三氟乙基酯 酰基供体 代替传统的有机甲酯 溶剂 如 乙腈 低 水内容。这种方法对于合并非蛋白质 氨基酸 如卤代苯丙氨酸成 肽。