盐酸氧氟沙星 | 118120-51-7

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 喹诺酮类药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 盐酸氧氟沙星
• 中文别名: (+/-)-9-氟-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧-2,3-二氢-7H-吡啶并[1,2,3-de][1,4]苯并恶嗪-6；(+/-)-9-氟-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧-2,3-二氢-7H-吡啶并[1,2,3-de][1,4]苯并恶嗪-6-羧酸盐酸盐；氧氟沙星盐酸盐
• 英文名称: 7-Fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydron;chloride
• CAS: 118120-51-7
• 化学式: C18H21ClFN3O4
• 分子量: 397.8
• InChiKey: CAOOISJXWZMLBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  73.3
• 氢给体数：
  2
• 氢受体数：
  8

制备方法与用途

盐酸氧氟沙星是一种喹诺酮类抗生素，现在临床常用其左旋体——盐酸左氧氟沙星。

它可用于制备一种复合型可降解的抗菌人工硬脑膜，成分包括万古霉素或盐酸氧氟沙星注射液、壳聚糖及β-甘油磷酸钠。

此外，全合成的抗菌素盐酸氧氟沙星广泛用于治疗各种由细菌感染引起的疾病。

文献信息

• METHOD FOR TREATMENT OF OVERFILTERING AND LEAKING BLEBS WITH STERILE TALC
  申请人：MOR RESEARCH APPLICATIONS LTD

  公开号：EP2112927A2

  公开（公告）日：2009-11-04
• IMPLANT MATERIAL
  申请人：KUHN KLAUS DIETER

  公开号：US20070190109A1

  公开（公告）日：2007-08-16

  Form bodies, which can be rotationally-symmetrical or irregularly-shaped, consist of at least one member of the group of the antibiotic salts, gentamicin myristate, gentamicin palmitate, gentamicin stearate, tobramycin myristate, tobramycin palmitate, tobramycin stearate, amikacin myristate, amikacin palmitate, amikacin stearate, vancomycin palmitate, vancomycin stearate, ramoplanin palmitate, ramoplanin stearate, levofloxacin palmitate, levofloxacin stearate, ofloxacin palmitate, ofloxacin stearate, moxifloxacin palmitate, moxifloxacin stearate, clindamycin palmitate, and clindamycin stearate. A medical device for implantation, in which the form bodies are arranged on a biodegradable filament at a distance of 1 mm to 25 mm as well as a method for the manufacture of the medical device and the use of the form bodies or the medical device to treat chronic osteomyelitis are described.
• AVIAN INFLUENZA VIRUSES, VACCINES, COMPOSITIONS, FORMULATIONS, AND METHODS
  申请人：Hoffmann Erich

  公开号：US20080118531A1

  公开（公告）日：2008-05-22

  A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined hemagglutinin (HA) total is at least about 200 HA/dose of the vaccine composition, and wherein each of the strains presents at least about 128 HA/dose, and further wherein one of the strains has the same HA subtype as that of a challenge virus, and wherein at least one of the strains has a different NA subtype than the challenge virus.
• Method for treatment of overfiltering and leaking blebs with sterile talc
  申请人：Geyer Orna

  公开号：US20090291149A1

  公开（公告）日：2009-11-26

  The present invention provides a method for treatment of overfiltering and leaking blebs in patients after glaucoma surgery comprising administering to said leaking bleb an effective amount of sterile talc, to thereby seal said leaking bleb and prevent bleb leakage.
• US7858109B2
  申请人：——

  公开号：US7858109B2

  公开（公告）日：2010-12-28