2-[(4-cyano-phenyl)-hydroxymethyl]-malonic acid di-tert-butyl ester | 1204142-58-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 2-[(4-cyano-phenyl)-hydroxymethyl]-malonic acid di-tert-butyl ester
• CAS: 1204142-58-4
• 化学式: C₁₉H₂₅NO₅
• 分子量: 347.411
• InChiKey: PTCIIQUVNJQQAC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 2-[(4-cyano-phenyl)-hydroxymethyl]-malonic acid di-tert-butyl ester 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2[(4-cyano-phenyl)-(trimethylsiloxy)-methyl]-malonic acid di-tert-butyl ester
  参考文献：
  名称：

  Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN

  摘要：

  The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to beta-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.057
• 作为产物：
  描述：

  在 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 2-[(4-cyano-phenyl)-hydroxymethyl]-malonic acid di-tert-butyl ester
  参考文献：
  名称：

  Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN

  摘要：

  The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to beta-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.057