(1R,2S,3S)-2-(2-Hydroxyethyl)-1,3-dimethyl-3-vinylcyclohexanol | 152611-89-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,2S,3S)-2-(2-Hydroxyethyl)-1,3-dimethyl-3-vinylcyclohexanol
• 英文别名: (1R,2S,3S)-3-ethenyl-2-(2-hydroxyethyl)-1,3-dimethylcyclohexan-1-ol
• CAS: 152611-89-7
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: MJIXILLMDNSZQE-QJPTWQEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2S,3S)-2-(2-Hydroxyethyl)-1,3-dimethyl-3-vinylcyclohexanol 在 molecular sieve 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到(-)-7a-epi-Epianastrephin
  参考文献：
  名称：

  Total syntheses of (-)-anastrephin, (-)-epianastrephin, and their 7a-epimers: use of samarium(II) iodide-mediated intramolecular reductive coupling for the construction of their hexahydrobenzofuran-2(3H)-one skeletons

  摘要：

  D-Glucose-derived alpha,beta-unsaturated ester 17, which includes a geminally and differntially substituted gamma-carbon and a terminal aldehyde functionality, was subjected to a SMI2-Mediated intramolecular reductive coupling reaction in a THF solution containing 1/10 volume of HMPA. The reaction proceeded with moderate stereoselectivity to provide a diastereomeric mixture of hexahydrobenzofuran-2 (3H)-ones, in which cis-fused product 25 was obtained as the major isomer in 35% isolated yield. Two trans-fused coupling products 26 (17%) and 27 (14%) were also obtained. Starting from major product 25, the insect sex attractants (-)-anastrephin (1) and (-)-epianastrephin (2) were synthesized enantiospecifically. Two unnatural stereocongeners, (-)-7a-epi-anastrephin (3) and (-)-7a-epi-epianastrephin (4), were also derived from 25.

  DOI：

  10.1021/jo00075a021
• 作为产物：
  描述：

  (2R,3R,4R,5S)-2,3-(Isopropylidenedioxy)-5-<(1R)-1,2-(isopropylidenedioxy)ethyl>-4-<(Z)-2-(methoxycarbonyl)ethenyl>-4-<4-<(tert-butyldimethylsilyl)oxy>butyl>tetrahydrofuran 在 palladium on activated charcoal 咪唑 、 盐酸 、 六甲基磷酰三胺 、 sodium tetrahydroborate 、 sodium periodate 、 lithium aluminium tetrahydride 、 molecular sieve 、 samarium diiodide 、 Raney nickel T-4 、 四丁基氟化铵 、 氢气 、 四氯化钛 、 sodium hydride 、 碳酸氢钠 、 间氯过氧苯甲酸 、 异丙醇 、 pyridinium chlorochromate 、 三氟乙酸 、 锌 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 283.83h， 生成 (1R,2S,3S)-2-(2-Hydroxyethyl)-1,3-dimethyl-3-vinylcyclohexanol
  参考文献：
  名称：

  Total syntheses of (-)-anastrephin, (-)-epianastrephin, and their 7a-epimers: use of samarium(II) iodide-mediated intramolecular reductive coupling for the construction of their hexahydrobenzofuran-2(3H)-one skeletons

  摘要：

  D-Glucose-derived alpha,beta-unsaturated ester 17, which includes a geminally and differntially substituted gamma-carbon and a terminal aldehyde functionality, was subjected to a SMI2-Mediated intramolecular reductive coupling reaction in a THF solution containing 1/10 volume of HMPA. The reaction proceeded with moderate stereoselectivity to provide a diastereomeric mixture of hexahydrobenzofuran-2 (3H)-ones, in which cis-fused product 25 was obtained as the major isomer in 35% isolated yield. Two trans-fused coupling products 26 (17%) and 27 (14%) were also obtained. Starting from major product 25, the insect sex attractants (-)-anastrephin (1) and (-)-epianastrephin (2) were synthesized enantiospecifically. Two unnatural stereocongeners, (-)-7a-epi-anastrephin (3) and (-)-7a-epi-epianastrephin (4), were also derived from 25.

  DOI：

  10.1021/jo00075a021