[(1R,2R)-1,2-Bis-(3-hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester | 659725-89-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: [(1R,2R)-1,2-Bis-(3-hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester
• 英文别名: (R,R)-N-Boc-N'-tosyl-1,2-Di(3-hydroxyphenyl)ethane-1,2-diamine；tert-butyl N-[(1R,2R)-1,2-bis(3-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]ethyl]carbamate
• CAS: 659725-89-0
• 化学式: C₂₆H₃₀N₂O₆S
• 分子量: 498.6
• InChiKey: UTDZXYMQPAQUKA-DNQXCXABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  [(1R,2R)-1,2-Bis-(3-benzyloxy-phenyl)-2-(toluene-4-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester 在 10percent Pd/C 氢气 作用下， 以 乙醇 为溶剂， 以100%的产率得到[(1R,2R)-1,2-Bis-(3-hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Asymmetric transfer hydrogenation of ketones with a polymer-supported chiral diamine

  摘要：

  A new supported chiral diamine has been developed and shown to be highly effective in ruthenium-catalysed asymmetric transfer hydrogenation of simple aromatic ketones. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.104

文献信息

• Nitrogen-containing ligands
  申请人：Hems Patrick William

  公开号：US20060135355A1

  公开（公告）日：2006-06-22

  An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R 5 , R 6 , R 7 and R 8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a urethane group, a sulphonyl group or form an imine group, R 1 , R 2 , R 3 , and R 4 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group or an aryl group and at least one of R 1 , R 2 , R 3 and R 4 is functionalised with a functional group, and a solid support having a site capable of reacting with said functional group. The nitrogen-containing ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.

  描述了一种固定化含氮配体，其包括式(I)的化合物的反应产物，其中R5、R6、R7和R8独立地为氢、饱和或不饱和的C1-C10烷基、芳基、脲基、磺酰基或形成亚胺基，R1、R2、R3和R4独立地为氢、饱和或不饱和的C1-C10烷基或芳基，且其中至少一个R1、R2、R3和R4被官能团官能化，以及具有能与所述官能团反应的位点的固体支持。该含氮配体可用于制备固定化催化剂，用于进行不对称催化等反应。
• Immobilisable ligands derived from ethylenediamine
  申请人：Johnson Matthey PLC

  公开号：EP1676635A2

  公开（公告）日：2006-07-05

  A ligand of formula (I) is described wherein R1, R3, R5, R6, R7 and R8 are hydrogen, characterized in that R2 and R4 are functional group-containing aryl groups in which the functional groups are selected from the group consisting of halogen (Cl, Br, F or I), hydroxyl, alkoxy, carbonyl, carboxyl, anhydride, carbene, methacryl, epoxide, vinyl, nitrile, mercapto, amine, imine, amide and imide. The ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.

  描述了一种式 (I) 配体 其中 R1、R3、R5、R6、R7 和 R8 为氢，其特征在于 R2 和 R4 为含官能团的芳基，其中官能团选自由卤素（Cl、Br、F 或 I）、羟基、烷氧基、羰基、羧基、酸酐、碳烯基、甲基丙烯酸酯、环氧化物、乙烯基、腈、巯基、胺、亚胺、酰胺和亚胺组成的组。配体可用于制备进行不对称催化等的固定化催化剂。
• NITROGEN-CONTAINING LIGANDS
  申请人：Johnson Matthey PLC

  公开号：EP1545772A2

  公开（公告）日：2005-06-29
• [EN] NITROGEN-CONTAINING LIGANDS<br/>[FR] LIGANDS CONTENANT DE L'AZOTE
  申请人：JOHNSON MATTHEY PLC

  公开号：WO2004014551A2

  公开（公告）日：2004-02-19

  An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R5, R6, R7 and R8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a urethane group, a sulphonyl group or form an imine group, R1, R2, R3 , and R4 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group or an aryl group and at least one of R1, R2, R3 and R4 is functionalised with a functional group, and a solid support having a site capable of reacting with said functional group. The nitrogen-containing ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.