The present invention describes a process for the selective synthesis of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono ester derivatives starting from N-Fmoc-doxorubicin using lipase enzymes and bis-acyl donor compounds such as dicarboxylic acids or anhydrides.
本发明描述了一种利用
脂肪酶和双酰基供体化合物(如二
羧酸或酸酐)从 N-Fmoc-doxorubicin 开始选择性合成 N-Fmoc-doxorubicin-14-O-二
羧酸单酯衍
生物的工艺。