2--6-methyl-7-<5-(phenylmethoxy)-1,4,5-trimethyl-trans-2-hexenyl>bicyclo-<4.3.0>non-2-en-8-ol | 142700-45-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2--6-methyl-7-<5-(phenylmethoxy)-1,4,5-trimethyl-trans-2-hexenyl>bicyclo-<4.3.0>non-2-en-8-ol
• 英文别名: 2-[dimethyl(1,1-dimethylethyl)siloxy]-6-methyl-7-[5-(phenylmethoxy)-1,4,5-trimethyl-trans-2-hexenyl]bicyclo-[4.3.0]non-2-en-8-ol；(1R,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(E,2R,5S)-5,6-dimethyl-6-phenylmethoxyhept-3-en-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-2-ol
• CAS: 142700-45-6
• 化学式: C₃₂H₅₂O₃Si
• 分子量: 512.849
• InChiKey: MMDMSYSWTKYUJF-BJMJCTKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.51
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2--6-methyl-7-<5-(phenylmethoxy)-1,4,5-trimethyl-trans-2-hexenyl>bicyclo-<4.3.0>non-2-en-8-ol 在 正丁基锂 、 四甲基乙二胺 、 lithium 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 甲胺 为溶剂， 反应 3.05h， 生成 cis-6-methyl-7-(5-hydroxy-1,4,5-trimethyl-2-hexenyl)-2,3,3a,6,7,7a-hexahydroindan-4(5H)-one
  参考文献：
  名称：

  An intramolecular Diels-Alder approach to the cis ring fused isomer of the 25-hydroxy vitamin D2 Grundmann ketone

  摘要：

  Stereospecific Claisen and intramolecular Diels-Alder reactions of chiral ester synthon 4 results in conversion of a single asymmetric center of commercially available ester 4 to a vitamin D synthon, the C/D cis Grundmann ketone 3. The addition of propenyllithium to aldehyde 9 was dominated by a chelated anti-Cram transition state and yielded the threo isomer 12a as the major product. The stereochemistry of 12a was determined by X-ray crystallography. Conversion of benzyl-protected erythro isomer 11b to its dimethylacryloyl ester followed by ester enolate Claisen rearrangement led to the C17 and C20 stereochemistry of vitamin D. Addition of a pentadienyl anion to aldehyde 15 gave a tetraene, 17, which underwent an intramolecular Diels-Alder reaction to produce compound 18. Removal of the C16 hydroxyl and hydrolysis gave only the cis-fused isomer of 3.

  DOI：

  10.1021/jo00042a014
• 作为产物：
  描述：

  2,3-dimethyl-4-<(2-methoxyethoxy)methoxy>-2-(phenylmethoxy)butane 在 盐酸 、 lithium aluminium tetrahydride 、 正丁基锂 、 三甲基氯硅烷 、 草酰氯 、 2,2,6,6-tetramethylpiperidinyl-lithium 、 仲丁基锂 、 lithium 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 甲苯 为溶剂， 反应 20.67h， 生成 2--6-methyl-7-<5-(phenylmethoxy)-1,4,5-trimethyl-trans-2-hexenyl>bicyclo-<4.3.0>non-2-en-8-ol
  参考文献：
  名称：

  An intramolecular Diels-Alder approach to the cis ring fused isomer of the 25-hydroxy vitamin D2 Grundmann ketone

  摘要：

  Stereospecific Claisen and intramolecular Diels-Alder reactions of chiral ester synthon 4 results in conversion of a single asymmetric center of commercially available ester 4 to a vitamin D synthon, the C/D cis Grundmann ketone 3. The addition of propenyllithium to aldehyde 9 was dominated by a chelated anti-Cram transition state and yielded the threo isomer 12a as the major product. The stereochemistry of 12a was determined by X-ray crystallography. Conversion of benzyl-protected erythro isomer 11b to its dimethylacryloyl ester followed by ester enolate Claisen rearrangement led to the C17 and C20 stereochemistry of vitamin D. Addition of a pentadienyl anion to aldehyde 15 gave a tetraene, 17, which underwent an intramolecular Diels-Alder reaction to produce compound 18. Removal of the C16 hydroxyl and hydrolysis gave only the cis-fused isomer of 3.

  DOI：

  10.1021/jo00042a014