3-(4-bromophenyl)-4-butylselanyl-6-methyl-2H-chromene | 1190602-58-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(4-bromophenyl)-4-butylselanyl-6-methyl-2H-chromene
• CAS: 1190602-58-4
• 化学式: C₂₀H₂₁BrOSe
• 分子量: 436.25
• InChiKey: MQIGSWHOHHLFLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.94
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-iodo-6-methyl-4(1-butylselenyl)-2H-benzopyran 、 4-溴苯硼酸 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以96%的产率得到3-(4-bromophenyl)-4-butylselanyl-6-methyl-2H-chromene
  参考文献：
  名称：

  Synthesis of 3-aryl-4-chalcogen-2H-benzopyrans from 3-iodo-4-chalcogen-2H-benzopyrans using a Suzuki cross-coupling

  摘要：

  The Suzuki cross-coupling reaction of 3-iodo-4-chalcogen-2H-benzopyran derivatives with a variety of organoboron compounds in the presence of catalytic amount of palladium salt is described. This cross-coupling reaction proceeded cleanly and was performed with aryl boronic acids bearing electron-withdrawing, electron-donating, and neutral substituents, furnishing the corresponding products in moderate to good yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.008

文献信息

• Synthesis of 3-aryl-4-chalcogen-2H-benzopyrans from 3-iodo-4-chalcogen-2H-benzopyrans using a Suzuki cross-coupling
  作者：Benhur Godoi、José S.S. Neto、Adriane Sperança、Carmine Ines Acker、Cristina W. Nogueira、Gilson Zeni

  DOI：10.1016/j.tetlet.2009.07.008

  日期：2009.9

  The Suzuki cross-coupling reaction of 3-iodo-4-chalcogen-2H-benzopyran derivatives with a variety of organoboron compounds in the presence of catalytic amount of palladium salt is described. This cross-coupling reaction proceeded cleanly and was performed with aryl boronic acids bearing electron-withdrawing, electron-donating, and neutral substituents, furnishing the corresponding products in moderate to good yields. (C) 2009 Elsevier Ltd. All rights reserved.