{2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-8-methoxy-quinolin-7-yl}-pyridin-4-yl-methanol | 866036-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: {2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-8-methoxy-quinolin-7-yl}-pyridin-4-yl-methanol
• CAS: 866036-57-9
• 化学式: C₂₆H₂₄N₂O₄
• 分子量: 428.488
• InChiKey: RYOCWYXOXVLKKF-XBXARRHUSA-N

反应信息

• 作为反应物：
  描述：

  {2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-8-methoxy-quinolin-7-yl}-pyridin-4-yl-methanol 在 manganese(IV) oxide 、 三溴化硼 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 16.0h， 生成 {2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinolin-7-yl}-pyridin-4-yl-methanone
  参考文献：
  名称：

  New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity

  摘要：

  Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.036
• 作为产物：
  描述：

  7-Bromo-2-[(E)-2-(3,4-dimethoxy-phenyl)-vinyl]-8-methoxy-quinoline 、 4-吡啶甲醛 在 苯基锂 、 六甲基磷酰三胺 作用下， 以 乙醚 、 环己烷 、 四氢呋喃 为溶剂， 生成 {2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-8-methoxy-quinolin-7-yl}-pyridin-4-yl-methanol
  参考文献：
  名称：

  New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity

  摘要：

  Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.036