oleana-11:13(18)-dien-3β-ol | 117073-98-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: oleana-11:13(18)-dien-3β-ol
• 英文别名: 3β-hydroxyoleana-11,13(18)-diene；3β-hydroxy-olean-11,13(18)-dien；(4aR)-10c-hydroxy-2.2.4ar.6at.6bc.9.9.12ac-octamethyl-(8atH.12btH)-Δ^13.14a-octadecahydro-picene；(4aR)-10c-Hydroxy-2.2.4ar.6at.6bc.9.9.12ac-octamethyl-(8atH.12btH)-Δ^13.14a-octadecahydro-picen；(3S,4aR,6aR,6bS,8aR,14aR,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-ol
• CAS: 117073-98-0
• 化学式: C₃₀H₄₈O
• 分子量: 424.711
• InChiKey: JQFQUXQUOLIBLM-YDPPSCFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  oleana-11:13(18)-dien-3β-ol 、 乙酸酐 在 吡啶 作用下， 反应 24.0h， 以3 mg的产率得到3β-acetoxy-oleana-11,13(18)-diene
  参考文献：
  名称：

  三萜二烯醇和来自柔韧叶的树皮的其他成分

  摘要：

  摘要 除了4种已知的三萜类化合物和bergenin外，从Phyllanthus flexuosus的茎皮中还分离到了ent-3β-hydroxykaur-16-ene和两种齐墩果二烯醇。树皮还含有正烷烃、正烷醇和植物甾醇。

  DOI：

  10.1016/0031-9422(88)80141-9
• 作为产物：
  描述：

  Β-香树脂醇乙酸酯 在 selenium(IV) oxide 、 水 、 溶剂黄146 作用下， 生成 oleana-11:13(18)-dien-3β-ol
  参考文献：
  名称：

  Long-term glycemic control measurements in diabetic patients receiving hemodialysis

  摘要：

  Cardiovascular morbidity is increased in patients with diabetes mellitus and there is a great prevalence of diabetes and cardiovascular disease among patients with end-stage renal disease (ESRD). Control of glycemia can decrease cardiovascular and end-organ damage. Because the validity of glycemic control tests have not been rigorously studied in patients with ESRD, we evaluated the value of various measures in these patients. The overall clinical goal was to investigate whether hemoglobin A(1)C (A(1)C) accurately reflects actual glycemic control as compared with other measures in light of the importance of attaining appropriately controlled blood glucose (BG). The commonly used tests of total glycated hemoglobin (GHb) and A(1)C may be unreliable in patients with ESRD because of the presence of anemia, shortened red blood cell (RBC) survival, and assay interferences from uremia. The primary aim of this study was to assess the relationship of capillary BG measurements to A(1)C, GHb, total glycated plasma proteins (GPP), and fructosamine (Fr) in diabetic patients receiving hemodialysis. Twenty-three patients were instructed to obtain BG evaluations twice daily for 7 days by using the Elite glucometer (Bayer Corporation, Elkhart, IN). These determinations included 6 fasting, 6 preprandial, and 3 separate 2-hour postprandial levels. Blood was obtained on day 7 for measurement of A(1)C, GHb, GPP, and Fr. A(1)C was analyzed by an immunoassay, GPP and GHb were assayed by affinity high-performance liquid chromatography (HPLC), and Fr by automated nitroblue colorimetric assay. Scatter plots were generated by plotting the average BG versus A(1)C, GHb, GPP, or Fr. Linear regression was performed for each plot showing the following relationships: A(1)C = 0.0174 (BG) + 4.76 (r = 0.58; P < 0.05): GHb = 0.0371 (BG) + 3.57 (r = 0.584; P < 0.05): GPP = 0.0083 (BG) + 26.13 (r = 0.065; P = 0.77): Fr = 0.6865 (BG) + 250 (r = 0.345; P = 0.11). Despite anemia and shortened RBC lifespan in patients with ESRD, A(1)C in the range of 6% to 7% estimates glycemic control similarly to patients without severe renal impairment. A(1)C values above 7.5% may overestimate hyperglycemia in patients with ESRD. Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus. (C) 2002 by the National Kidney Foundation, Inc.

  DOI：

  10.1053/ajkd.2002.30549

文献信息

• The structure of dispermoquinone
  作者：J.D. Martin

  DOI：10.1016/s0040-4020(01)93434-9

  日期：1973.1

  Structure 1 for dispermoquinone, a triterpenoid quinone methide isolated from Maytenus dispermus is proposed on the basis of chemical and spectroscopic evidence.

  根据化学和光谱学证据，提出了一种用于分散对苯二酚的结构1，即从美登木（Maytenus dispermus）分离出的三萜类醌甲基化物。
• Green et al., Journal of the Chemical Society, 1944, p. 527,532
  作者：Green et al.

  DOI：——

  日期：——
• 736. Triterpene resinols and related acids. Part XXIV. 18-iso-β-Amyranol
  作者：Richard Budziarek、William Manson、F. S. Spring

  DOI：10.1039/jr9510003336

  日期：——
• David, Bulletin de la Societe Chimique de France, 1949, p. 155,157
  作者：David

  DOI：——

  日期：——
• TANAKA, REIKO;MATSUNAGA, SHUNYO, PHYTOCHEMISTRY, 27,(1988) N 7, C. 2273-2277
  作者：TANAKA, REIKO、MATSUNAGA, SHUNYO

  DOI：——

  日期：——