3β-Acetoxyolean-9(11),12-diene | 2118-76-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-Acetoxyolean-9(11),12-diene
• 英文别名: oleana-9(11),12-dien-3β-yl acetate；[(3S,4aR,6aS,6bR,8aR,12aR,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a-dodecahydropicen-3-yl] acetate
• CAS: 2118-76-5
• 化学式: C₃₂H₅₀O₂
• 分子量: 466.748
• InChiKey: CRTYUOWLXGQWPS-ROMLAASOSA-N

物化性质

• 熔点：
  215-216 °C
• 沸点：
  516.0±50.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3β-Acetoxyolean-9(11),12-diene 在 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 作用下， 生成 Olean-9(11),12,18-trien-3β-yl-acetat
  参考文献：
  名称：

  145.三萜烯树脂醇和相关酸。第十八部分。的转化β -amyratrienyl醋酸成β -amyradiendionyl乙

  摘要：

  DOI：

  10.1039/jr9440000532
• 作为产物：
  描述：

  3β-hydroxyolean-12-en-11-one acetate 在 氢氧化钾 、 戊醇 、 sodium 作用下， 生成 3β-Acetoxyolean-9(11),12-diene
  参考文献：
  名称：

  Probabilité d’embolie gazeuse causée par des produits de combustion pendant l’hystéroscopie peropératoire

  摘要：

  Purpose: Gas embolism is a rare but well documented entity during operative hysteroscopy, with an incidence of 10-50%. Catastrophic outcomes occur at a rate of three in 17,000 procedures. The purpose of this report is to present a non-fatal case of gas embolism probably caused by the gaseous products of combustion.Clinical features: A 50-yr-old woman with a history of menorrhagia was scheduled for hysteroscopy and endometrial ablation and polypectomy. Fifteen minutes into the procedure, with the patient in lithotomy position, 20degrees head down tilt, and breathing spontaneously, a sudden oxygen desaturation occurred from 97% to 87%. The patient's end-tidal carbon dioxide dropped from 46 mmHg to 27 mmHg. The patient's breathing pattern remained normal, respiratory rate remained 11- 12 breaths-min(-1) but amplitude of the reservoir bag movement was increased. Cardiovascular variables remained stable. She responded rapidly to 100% oxygen and made an uneventful recovery. Having ruled out other possible causes, we concluded gas embolism was responsible for the fall in oxygen saturation and end-tidal CO2.Conclusion: With all the precautions in place to minimize the likelihood of fluid overload and ambient air embolism occurring, we surmised that products of combustion were the cause of the gas embolism. During endometrial ablation, gaseous products of combustion, mainly carbon dioxide, accumulate. The gases may then contribute to the rise in uterine pressure that occurs as irrigation fluid enters the uterus and this rise in pressure in turn encourages passage of gas into the open venous sinuses.

  DOI：

  10.1007/bf03017899

文献信息

• Triterpene dienols and other constituents from the bark of Phyllanthus flexuosus
  作者：Reiko Tanaka、Shunyo Matsunaga

  DOI：10.1016/0031-9422(88)80141-9

  日期：1988.1

  Abstract Besides four known triterpenes and bergenin, ent-3β-hydroxykaur-16-ene and two oleanadienols were isolated from the stem bark of Phyllanthus flexuosus. The bark also contained n-alkanes, n-alkanols and phytosterols.

  摘要 除了4种已知的三萜类化合物和bergenin外，从Phyllanthus flexuosus的茎皮中还分离到了ent-3β-hydroxykaur-16-ene和两种齐墩果二烯醇。树皮还含有正烷烃、正烷醇和植物甾醇。
• Chauhan; Mohapatra; Mamta, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 3, p. 183 - 189
  作者：Chauhan、Mohapatra、Mamta、Parkash、Azam

  DOI：——

  日期：——
• 233. The resinols. Part V. β-Amyrenonol and dehydro-β-amyrenol. The location of the unsaturated centres of the α- and β-amyrenols
  作者：J. H. Beynon、K. S. Sharples、F. S. Spring

  DOI：10.1039/jr9380001233

  日期：——
• 225. The triterpene resinols and related acids. Part X. β-Amyradienol
  作者：C. W. Picard、F. S. Spring

  DOI：10.1039/jr9400001198

  日期：——
• Bhaumik, Tapanjyoti; Dey, A. K.; Das, P. C., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 8, p. 664 - 668
  作者：Bhaumik, Tapanjyoti、Dey, A. K.、Das, P. C.、Mukhopadhyay, A. K.、Chatterjee, A.

  DOI：——

  日期：——