Ethyl 4-(2-acetylphenoxy)butanoate | 190786-05-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Ethyl 4-(2-acetylphenoxy)butanoate
• CAS: 190786-05-1
• 化学式: C₁₄H₁₈O₄
• 分子量: 250.295
• InChiKey: QMTWYQCBWLDQQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 4-(2-acetylphenoxy)butanoate 在 盐酸 、 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 、 盐酸羟胺 、 sodium acetate 、 2,4-滴二甲胺盐 、 sodium hydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 、 水 、 二甲基亚砜 为溶剂， 生成 2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>benzofuran-5-carboxylic acid
  参考文献：
  名称：

  Synthesis and 5α-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group

  摘要：

  A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5 alpha-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00001-8
• 作为产物：
  描述：

  4-溴丁酸乙酯 、 2'-羟基苯乙酮 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以86%的产率得到Ethyl 4-(2-acetylphenoxy)butanoate
  参考文献：
  名称：

  Synthesis and 5α-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group

  摘要：

  A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5 alpha-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00001-8

文献信息

• Synthesis and 5α-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group
  作者：Koki Ishibashi、Katsuyoshi Nakajima、Yuki Sugioka、Mitsuo Sugiyama、Takakazu Hamada、Hiroyoshi Horikoshi、Takahide Nishi

  DOI：10.1016/s0960-894x(98)00001-8

  日期：1998.3

  A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5 alpha-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.