Dma 4 ivm herbicide is a brown liquid. A solution of the dimethylammonium salt of the weak organic acid 2,4-dichlorophenoxyacetic acid. Used as an herbicide.
颜色/状态：
White crystals
气味：
Odorless /Pure/
闪点：
THE ACID AND SALTS ARE NONFLAMMABLE. HOWEVER, COMMERCIAL FORMULATIONS OF /2,4-D FREE/ ACID MAY HAVE FLASH POINT MINIMUM OF 88 °C (CLEVELAND OPEN CUP) ...
蒸汽压力：
1.00e-09 mmHg
稳定性/保质期：
Most amine formulations have no shelf life limitations and are insensitive to light and temperature. /2,4-D/
分解：
When heated to decomposition it emits very toxic fumes of /hydrogen chloride, ammonia, & nitrogen oxides/.
HERBICIDAL ACTIVITY OF ESTERS, NITRILES, AMINES (&, OF COURSE, SALTS) APPEARS SIMILAR IF NOT IDENTICAL TO PARENT ACID. THIS IS APPARENTLY DUE TO PRESENCE OF HYDROLYTIC ENZYMES IN PLANTS & IN SOIL MICROORGANISMS THAT CONVERT THESE DERIVATIVES TO PARENT ACID.
Chlorophenoxy acid derivatives are metabolized via participation of the hepatic microsomal mixed-function oxidase system. Thus, administration of 2,4-D amine salt and its butyl ester ... to rats induced the enzyme system (aminopyrine demethylase ... and aniline hydroxylase) ... although the degree of induction was substantially lower than that from phenobarbital. Prolonged administration of 2,4-D amine salt (0.1 LD50) showed cumulative effects reflected by both clinical and biochemical changes. Stimulation of mixed-function oxidase system may be one of the methods for reducing toxicological effects of this type of compounds.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
A4；不可分类为人类致癌物。/2,4-D/
A4; Not classifiable as a human carcinogen. /2,4-D/
Classification of carcinogenicity: 1) evidence in humans: limited; overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. /SRP: The older literature indicated that these compounds were carcinogenic. It was discovered that this was due to contamination, including dioxin./ /Chlorophenoxy herbicides; From table/
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.
ACGIH Carcinogen - Not Classifiable.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
毒理性
毒性数据
LC50 (大鼠) > 3,500 毫克/立方米
LC50 (rat) > 3,500 mg/m3
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Monitor body temperature and treat if necessary. /Chlorophenoxy herbicides and related compounds/
The dimethylamine salt of (14)C-ring-labeled 2,4-D was administered to Fisher 344 rats orally (1 and 0.4 mg/kg body weight) and dermally (10 mg/kg body weight). Absorption, distribution, and elimination were determined from (14)C-labeled 2,4-D in blood, tissues, and excreta. Most of the orally administered dose (94-96%) became systemically available within 6 hr. Following dermal administration 10% of the dose became systemically available over 72 hr. However, peak concentrations in blood and kidney were achieved within 30 min of dosing by either route. By 1.5 hr after dosing, 2,4-D concentrations in blood, muscle, liver, and kidneys had decreased in both the orally dosed and dermally dosed animals. Between 2 and 8 hr, the blood, muscle, liver, and kidney concentrations in dermally dosed animals maintained a plateau while urinary excretion increased, presumably due to continued absorption 2,4-D from the skin. The concentrations in orally dosed animals continued to decrease. Following 7 hr of dermal exposure, skin cleansing removed about 63% of the applied dose; about 17% of the applied dose remained at the site of dermal dosing. At 8 hr, 2,4-D concentrations in blood, muscle, liver, and kidneys of dermally dosed animals began to decrease, most likely a result of the removal of the reservoir on the skin. However, 2,4-D continued to be absorbed from skin site, resulting in a slower decline of the 2,4-D concentrations in these tissues over remainder of the 72 hr study period. In animals that had been orally dosed, the absorbed dose was almost completely excreted within 24 hr.
Plant roots absorb polar (salt) forms /of 2,4-D/ most readily. ... Following root absorption, it may move upward in the transpiration stream. Translocation is influenced by the growth status of the plant. Accumulation of the herbicide occurs principally at the meristematic regions of shoots and roots. /2,4-D salt/
Synthesis of Annulated γ-Carbolines by Palladium-Catalyzed Intramolecular Iminoannulation
摘要：
[GRAPHICS]A variety of N-substituted 2-bromo-1H-indole-3-carboxaldehydes incorporating an alkyne-containing tether on the indole nitrogen have been converted to the corresponding tert-butylimines, which have been subjected to palladium-catalyzed intramolecular iminoannulation, affording various annulated gamma-carbolines in excellent yields.
[EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
申请人：BRISTOL MYERS SQUIBB CO
公开号：WO2012039717A1
公开（公告）日：2012-03-29
This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
The present invention relates to a compound of formula (I) wherein: R1 is C1-C3alkoxy, C1-C2alkoxy-C1-C3alkoxy, C1-C2fluoroalkoxy, ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl; R2 is hydrogen, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, C1-C3alkoxy, C1-C3fluoroalkyl, C1-C2fluoroalkoxy, C1-C2alkoxy-C1-C3alkoxy-, or C1fluoroalkoxy-C1-C3alkoxy-; provided that when R1 is ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl, then R2 is hydrogen, ethyl, n-propyl, cyclopropyl, vinyl or ethynyl; and Y is O, S, S(O), S(O)2, N(C1-C2alkyl), N(C1-C2alkoxy), C(O), CR8R9 or -CR10R11CR12R13-; and and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.
NOVEL COMPOUND HAVING MULTIMER STRUCTURE OF XANTHENE DERIVATIVE, COLORING COMPOSITION, INK FOR INKJET RECORDING, METHOD OF INKJET RECORDING, COLOR FILTER, AND COLOR TONER
申请人：FUJIFILM CORPORATION
公开号：US20140176653A1
公开（公告）日：2014-06-26
There is provided a compound represented by formula (1):
in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R
4
to R
24
independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.
COLORING CURABLE RESIN COMPOSITION, CURED FILM, COLOR FILTER, METHOD FOR MANUFACTURING COLOR FILTER, SOLID-STATE IMAGING DEVICE, IMAGE DISPLAY DEVICE, COMPOUND, AND CATION
申请人：FUJIFILM Corporation
公开号：US20160376234A1
公开（公告）日：2016-12-29
The present invention provides a colored curable resin composition that exhibits good heat resistance and durability in a sputtering process, a cured film, a color filter, a method for manufacturing a color filter, a solid-state image device, an image display device, a compound, and a cation. The colored curable resin composition contains a colorant represented by Formula (1), Formula (2), or Formula (3), a resin, a polymerizable compound, and a polymerization initiator. In Formula (1), R
101
and R
102
each independently represent a hydrogen atom or a substituent, R
103
to R
106
each independently represent a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group, R
107
to R
111
each independently represent a hydrogen atom or a substituent, n1 to n4 each independently represent an integer of 0 to 4, n5 represents an integer of 0 to 6, X represents an anion or is not present, and at least one of R
101
, . . . , or R
111
includes an anion; and in the case where R
101
and R
102
represent hydrogen atoms, R
103
represents an aryl group having a substituent at at least the ortho-position.
[EN] PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO<br/>[FR] COMPOSITIONS PESTICIDES ET PROCÉDÉS RELATIFS À CES COMPOSITIONS
申请人：DOW AGROSCIENCES LLC
公开号：WO2013009791A1
公开（公告）日：2013-01-17
This document discloses molecules having the following formula ("Formula One") The molecules disclosed in this document are related to the field of processes to produce molecules that are useful as pesticides (e.g., acaricides, insecticides, molluscicides, and nematicides), such molecules, and processes of using such molecules to control pests.
