3-{5-[3-benzyl-8-(trifluoromethyl)quinolin-4-yloxy]pentyl}-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-ethylimidazolidine-2,4-dione | 1192757-89-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 3-{5-[3-benzyl-8-(trifluoromethyl)quinolin-4-yloxy]pentyl}-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-ethylimidazolidine-2,4-dione
• 英文别名: 3-[5-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]oxypentyl]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-ethylimidazolidine-2,4-dione
• CAS: 1192757-89-3
• 化学式: C₃₅H₃₄F₃N₃O₅
• 分子量: 633.667
• InChiKey: KMCPWMRUBUEZRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• QUINOLINE COMPOUNDS
  申请人：KOURA Minoru

  公开号：US20100016327A1

  公开（公告）日：2010-01-21

  [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.

  提供一种新型的LXRβ激动剂，可用作预防和/或治疗动脉粥样硬化；动脉硬化，如糖尿病引起的动脉硬化；血脂异常；高胆固醇血症；与脂质相关的疾病；由炎症性细胞因子引起的炎症性疾病；过敏性皮肤病；糖尿病；或阿尔茨海默病的治疗剂。通过以下一般式（1）表示的喹啉化合物或其盐，或它们的溶剂化合物。
• QUINOLINE COMPOUND
  申请人：Kowa Company, Ltd.

  公开号：EP2272843A1

  公开（公告）日：2011-01-12

  It is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. It is related to a quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.

  本发明旨在提供一种新型 LXRβ 激动剂，可作为动脉粥样硬化、动脉硬化（如糖尿病引起的动脉硬化）、血脂异常、高胆固醇血症、血脂相关疾病、由炎性细胞因子引起的炎症性疾病、皮肤病（如过敏性皮肤病）、糖尿病或阿尔茨海默病的预防和/或治疗药物。它与由以下通式（1）代表的喹啉化合物或其盐或它们的溶解物有关。
• US8008306B2
  申请人：——

  公开号：US8008306B2

  公开（公告）日：2011-08-30