1-(1-((diisopropylcarbamoyl)oxy)ethyl)-3-((2-(nitrooxy)ethyl)carbamoyl)pyridin-1-ium | 1402916-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(1-((diisopropylcarbamoyl)oxy)ethyl)-3-((2-(nitrooxy)ethyl)carbamoyl)pyridin-1-ium
• 英文别名: 1-[3-(2-nitrooxyethylcarbamoyl)pyridin-1-ium-1-yl]ethyl N,N-di(propan-2-yl)carbamate
• CAS: 1402916-60-2
• 化学式: C₁₇H₂₇N₄O₆
• 分子量: 383.425
• InChiKey: GPPXOLZIBDVJEZ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• US9359376B2
  申请人：——

  公开号：US9359376B2

  公开（公告）日：2016-06-07
• [EN] NICORANDIL DERIVATIVES<br/>[FR] DÉRIVÉS DE NICORANDIL
  申请人：UNICYCIVE THERAPEUTICS INC

  公开号：WO2020190890A1

  公开（公告）日：2020-09-24

  Disclosed herein are pyridyl compounds. Also described are specific conjugated nicorandil compounds. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the pyridyl compounds are disclosed for the treatment of diseases or conditions related to kidney or kidney functions.