4-羟基-N,N-二(异)丙基色胺盐酸盐 | 63065-90-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 4-羟基-N,N-二(异)丙基色胺盐酸盐
• 英文名称: 4-hydroxy-N,N-diisopropyltryptamine hydrochloride
• 英文别名: n,n-Diisopropyl-4-hydroxytryptamine hydrochloride；3-[2-[di(propan-2-yl)amino]ethyl]-1H-indol-4-ol;hydrochloride
• CAS: 63065-90-7
• 化学式: C₁₆H₂₄N₂O*ClH
• 分子量: 296.84
• InChiKey: SBBDIXSABJRYFC-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMF：0.1mg/mL； DMSO：3mg/mL； DMSO:PBS(pH7.2)(1:1)：0.5mg/ml；甲醇：1mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  3.96
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  uridine 5'-diphosphoglucose disodium salt hydrate 、 4-羟基-N,N-二(异)丙基色胺盐酸盐 在 1,4-dithio-D,L-threitol 、 HEPES 、 sodium chloride 、 magnesium chloride 作用下， 以 水 为溶剂， 反应 6.0h， 生成 2-((3-(2-(diisopropylamino)ethyl)-1H-indol-4-yl)oxy)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  参考文献：
  名称：

  [EN] MODIFIED INDOLE ALKALOIDS FOR THERAPEUTIC USES
  [FR] ALCALOÏDES INDOLIQUES MODIFIÉS POUR UTILISATIONS THÉRAPEUTIQUES

  摘要：

  本文披露了制备改性吲哚生物碱的酶和改性宿主细胞方法。本文还披露了改性吲哚生物碱及其治疗用于治疗疾病和疾病的方法。

  公开号：

  WO2022133314A1

文献信息

• PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
  申请人：Bednarek Pawel

  公开号：US20090028796A1

  公开（公告）日：2009-01-29

  The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.

  本发明涉及包含吲哚衍生物的杀虫组合物。这些吲哚衍生物特别对植物病原真菌具有活性。此外，本发明涉及使用吲哚衍生物制备杀虫剂以及使用本发明中的组合物作为杀虫剂。本发明还涉及制备杀虫组合物的过程以及通过该过程制备的杀虫组合物。此外，本发明还涉及预防或对抗害虫的过程以及保护植物免受害虫，特别是植物病原真菌的过程。此外，本发明还涉及经过本发明中的组合物处理后受到保护的植物或种子以及物体或材料。本发明还涉及识别具有杀虫活性的物质的方法。此外，本发明还涉及识别本发明中杀虫化合物的作用方式和/或提供结合蛋白的方法。最后，本发明涉及诊断植物害虫感染的方法以及使用本发明中的杀虫化合物作为诊断标记的方法。
• OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX
  申请人：RheoGene Holdings Inc.

  公开号：EP1601354A2

  公开（公告）日：2005-12-07
• EP1601354A4
  申请人：——

  公开号：EP1601354A4

  公开（公告）日：2009-08-12
• [EN] OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX<br/>[FR] LIGANDS D'OXADIAZOLINE POUR LA MODULATION DE L'EXPRESSION DE GENES EXOGENES VIA UN COMPLEXE RECEPTEUR D'ECDYSONE
  申请人：RHEOGENE HOLDINGS INC

  公开号：WO2005017126A2

  公开（公告）日：2005-02-24

  The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
• [EN] PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES<br/>[FR] COMPOSITION PESTICIDE COMPRENANT DES DÉRIVÉS D'INDOLE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2007085660A1

  公开（公告）日：2007-08-02

  [EN] The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.
  [FR] La présente invention concerne des compositions pesticides comprenant des dérivés d'indole. Ces dérivés d'indole sont particulièrement actifs contre des champignons phytopathogènes. Cette invention concerne également l'utilisation de dérivés d'indole pour la production de pesticides et l'utilisation des compositions de cette invention comme pesticides. Cette invention concerne en outre: un procédé de production d'une composition pesticide et des compositions pesticides préparées par ce procédé; un procédé permettant de prévenir ou de combattre les organismes nuisibles et un procédé de protection des végétaux contre les organismes nuisibles, en particulier contre les champignons phytopathogènes; des végétaux ou des semences ainsi que des objets ou des matériaux qui ont été protégés contre les organismes nuisibles par traitement au moyen de la composition de cette invention; un procédé permettant d'identifier une substance présentant une activité pesticide; un procédé permettant d'identifier le mode d'action d'un composé pesticide et/ou d'obtenir des protéines de liaison pour un composé pesticide de cette invention. Cette invention concerne enfin un procédé permettant de diagnostiquer une infection d'un végétal par des organismes nuisibles et l'utilisation de composés pesticides comme marqueurs diagnostiques.