S-[2(III),3(III),4(III),6(III),2(II),3(II),6(II),2,3,6-deca-O-acetyl-β-maltotriosyl] thioacetate | 60347-94-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: S-[2(III),3(III),4(III),6(III),2(II),3(II),6(II),2,3,6-deca-O-acetyl-β-maltotriosyl] thioacetate
• 英文别名: 1-thioacetyl-2,3,6-tri-O-acetyl-4-O-(2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-α-O-glucopyranosyl)-α-D-glucopyranosyl)-β-D-glucopyranose；[(2R,3R,4S,5R,6R)-4,5-diacetyloxy-6-[(2R,3R,4S,5R,6S)-4,5-diacetyloxy-2-(acetyloxymethyl)-6-acetylsulfanyloxan-3-yl]oxy-3-[(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl acetate
• CAS: 60347-94-6
• 化学式: C₄₀H₅₄O₂₆S
• 分子量: 982.919
• InChiKey: NFYXKSNMMKBIFE-ARSFYRQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  67
• 可旋转键数：
  29
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  352
• 氢给体数：
  0
• 氢受体数：
  27

反应信息

• 作为反应物：
  描述：

  S-[2(III),3(III),4(III),6(III),2(II),3(II),6(II),2,3,6-deca-O-acetyl-β-maltotriosyl] thioacetate 在 吡啶 、 甲醇 、 D(+)-10-樟脑磺酸 、 sodium methylate 、 二乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 100.0h， 生成 pent-4-en-1-yl 4(III),6(III)-di-O-((2-naphthyl)methylidene)-2(III),3(III),2(II),3(II),6(II),2,3,6-octa-O-acetyl-1-thio-β-maltotrioside
  参考文献：
  名称：

  Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for α-amylase on the basis of fluorescence resonance energy transfer (FRET)

  摘要：

  A series of bi-fluorescence-labeled maltooligosaccharides that lead to fluorescence resonance energy transfer (FRET) was systematically synthesized. Effective FRETs were observed with all of the synthesized probes. Digestion of probes having tetra-, quintet-, hexa- or hepta-saccharidic chain lengths with human saliva alpha-amylase resulted in disappearance of FRET when an excitation wavelength of at 290 nm was used followed by detection at ca. 520 nm due to emission from the dansyl moiety. However, continuous FRET was observed when probes having di- or trisaccharidic chain lengths were used as substrates. In addition to the substrate characteristics based on saccharidic chain length, the reaction rates of digestion for the substrates by amylase were different and also depended on their saccharidic chain length. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.065
• 作为产物：
  描述：

  maltotriose peracetate 在 氢溴酸 、 溶剂黄146 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 21.5h， 生成 S-[2(III),3(III),4(III),6(III),2(II),3(II),6(II),2,3,6-deca-O-acetyl-β-maltotriosyl] thioacetate
  参考文献：
  名称：

  糖類連結クロリン誘導体

  摘要：

  题目：提供具有杀死肿瘤细胞（光毒性）能力的S-糖基化氯林衍生物。 解决方法：提供以下式中的S-糖基化氯林衍生物。（其中X1-X4是F-或寡糖-S-基团中的任意一个） 选择图：无

  公开号：

  JP2015147758A

文献信息

• [EN] REAGENTS AND METHODS FOR THE FORMATION OF DISULFIDE BONDS AND THE GLYCOSYLATION OF PROTEINS<br/>[FR] REACTIFS ET PROCEDES POUR FORMER DES LIAISONS DISULFURE ET POUR GLYCOSYLER DES PROTEINES
  申请人：ISIS INNOVATION

  公开号：WO2005000862A3

  公开（公告）日：2005-08-18
• Glyco-SeS: Selenenylsulfide-Mediated Protein Glycoconjugation—A New Strategy in Post-Translational Modification
  作者：David P. Gamblin、Philippe Garnier、Sander van Kasteren、Neil J. Oldham、Antony J. Fairbanks、Benjamin G. Davis

  DOI：10.1002/anie.200352975

  日期：2004.2.6