(-/+)-3,4-Dihydro-3-(2-hydroxy-4-methoxyphenyl)-8,8-dimethyl-2H,8H-benzo<1,2-b:3,4-b'>dipyran, | 88852-88-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: (-/+)-3,4-Dihydro-3-(2-hydroxy-4-methoxyphenyl)-8,8-dimethyl-2H,8H-benzo<1,2-b:3,4-b'>dipyran,
• 英文别名: 4'-O-methyglabridin；4'-O-methyl-glabridin；(R)-2-(8,8-dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)-5-methoxyphenol；2-(8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl)-5-methoxyphenol
• CAS: 88852-88-4
• 化学式: C₂₁H₂₂O₄
• 分子量: 338.403
• InChiKey: ZZAIPFIGEGQNHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(2-Benzyloxy-4-methoxyphenyl)-8,8-dimethyl-4H,8H-benzo<1,2-b:3,4-b'>dipyran-4-on 在 三氟化硼乙醚 、 镍 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 甲苯 、 苯 为溶剂， 反应 1.92h， 生成 (-/+)-3,4-Dihydro-3-(2-hydroxy-4-methoxyphenyl)-8,8-dimethyl-2H,8H-benzo<1,2-b:3,4-b'>dipyran,
  参考文献：
  名称：

  Vermes; Antus; Gottsegen, Liebigs Annalen der Chemie, 1983, vol. NO. 11, # 11, p. 2034 - 2037

  摘要：

  DOI：

文献信息

• PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR LIGANDS AND PROCESS FOR PRODUCING THE SAME
  申请人：KANEKA CORPORATION

  公开号：EP1440688A1

  公开（公告）日：2004-07-28

  The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

  本发明简便高效地提供了一种过氧化物酶体增殖体激活受体配体，以及一种用于改善胰岛素抵抗或预防和/或改善胰岛素抵抗综合征的组合物，其中含有该配体作为活性成分。 本发明涉及一种过氧化物酶体增殖体激活受体配体，它包括一种前黄酮类化合物、一种不包括前黄酮类化合物的查尔酮衍生物、一种不包括前黄酮类化合物的黄酮醇衍生物，以及可作为药物制剂或食品或饮料的盐、苷和/或酯化物质；一种含有上述配体的组合物；一种含有上述配体的植物提取物；以及一种生产上述提取物的工艺。
• PROCESSED FAT COMPOSITION FOR PREVENTING/AMELIORATING LIFESTYLE-RELATED DISEASES
  申请人：KANEKA CORPORATION

  公开号：EP1649854A1

  公开（公告）日：2006-04-26

  The obj ect of the invention is to provide a composition for prevention and/or amelioration of life-style related disease, and/or a composition for inhibition and/or amelioration of increase in body weight, comprising at least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3'-hydroxy-4'-O-methylglabridin, 4' -O-methylglabridin and hyspaglabridin B as compounds having a PPARγ ligand activity effective in amelioration of insulin resistance and in prevention and/or amelioration of life-style related diseases such as visceral fat obesity, type 2 diabetes, hyperlipemia and hypertension, which can be utilized in food and drink such as health food and health functional food (food for specifieduses and food with nutrient function) , pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. At least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3'-hydroxy-4'-O-methylglabridin, 4' -O-methylglabridin and hyspaglabridin B is dissolved in medium-chain fatty acid triglycerides and/or partial glycerides, whereby the stability of the compound (s) is improved and the processability thereof into food and drink, pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. is also improved.

  本发明的目的是提供一种用于预防和/或改善生活方式相关疾病的组合物，和/或一种用于抑制和/或改善体重增加的组合物，该组合物包含至少一种选自由格拉布林、格拉布林、格拉布醇、3'-羟基-4'-O-甲基格拉布林、4'-O-甲基格拉布林和 hyspaglabridin B 组成的组的化合物、4' -O-甲基格拉布甙和hypaglabridin B 作为具有 PPARγ 配体活性的化合物，可有效改善胰岛素抵抗，预防和/或改善与生活方式相关的疾病，如内脏脂肪肥胖、2 型糖尿病、高脂血症和高血压，可用于食品和饮料，如保健食品和保健功能食品（特定用途食品和具有营养功能的食品）、药物制剂、非药物制剂、化妆品等。将至少一种选自格拉布烯、格拉布林、格拉布罗尔、3'-羟基-4'-O-甲基格拉布林、4'-O-甲基格拉布林和 hyspaglabridin B 的化合物溶解在中链脂肪酸甘油三酯和/或部分甘油酯中，从而提高化合物的稳定性，并改善其加工成食品和饮料、药物制剂、非药物制剂、化妆品等的可加工性。
• OIL/FAT-CONTAINING COMPOSITION FOR SUPPRESSION OF CANCER DEVELOPMENT
  申请人：Kaneka Corporation

  公开号：EP1864643A1

  公开（公告）日：2007-12-12

  The present invention relates to an oil/fat-containing composition for suppressing carcinogenesis, the composition including a solution produced by bringing a hydrophobic extract of licorice, which has been produced by bringing licorice into contact with an alcohol, into contact with an oil/fat. According to the present invention, there are provided an oil/fat-containing composition for prevention or treatment of the cancer, which can act through oral administration, and can be safely ingested on a day-to-day basis, pharmaceuticals and foods containing the oil/fat-containing composition.

  本发明涉及一种用于抑制癌变的含油/脂组合物，该组合物包括一种溶液，该溶液是将甘草的疏水性提取物与油/脂接触后产生的，该提取物是将甘草与酒精接触后产生的。根据本发明，提供了一种用于预防或治疗癌症的含油/脂组合物，该组合物可以通过口服发挥作用，并且可以每天安全摄入，药品和食品中含有该含油/脂组合物。
• COMPOSITION CONTAINING LICORICE-DERIVED POLYPHENOL
  申请人：Kaneka Corporation

  公开号：EP2163252A1

  公开（公告）日：2010-03-17

  A composition containing a licorice polyphenol and other active ingredient (antioxidant ingredient, polyphenol other than licorice polyphenol or a component relating to lipid absorption or metabolism) is highly safe, can be produced easily, and can be utilized for foods and drinks such as health food, food with health claims (specified health food, food with nutrient function claims) and the like, pharmaceutical products, quasi-drugs, cosmetics and the like. In addition, since the composition has a body fat accumulation suppressing effect, a body fat decomposition promoting effect or energy production promoting effect, it is useful for the treatment of obesity, metabolic syndrome and the like.

  含有甘草多酚和其他活性成分（抗氧化成分、甘草多酚以外的多酚或与脂质吸收或代谢有关的成分）的组合物安全性高，易于生产，可用于保健食品、健康声称食品（指定保健食品、营养功能声称食品）等食品和饮料、医药产品、准药品、化妆品等。此外，由于该组合物具有抑制体内脂肪堆积的效果、促进体内脂肪分解的效果或促进能量产生的效果，因此可用于治疗肥胖症、代谢综合征等。
• METHOD OF PRODUCING REDUCED COENZYME Q10 AND METHOD OF STABILIZING THE SAME
  申请人：Kaneka Corporation

  公开号：EP2186789A1

  公开（公告）日：2010-05-19

  The present invention provides a stabilization method of reduced coenzyme Q10 useful as food, food with nutrient function claims, food for specified health uses, nutritional supplement, nutritional supplement, animal drugs, drinks, feeds, cosmetics, pharmaceutical products, therapeutic drugs, prophylactic drugs and the like, as well as a stabilized composition. Furthermore, it provides a convenient production method of reduced coenzyme Q10 using oxidized coenzyme Q10 as a starting material. In the present invention, oxidation of reduced coenzyme Q10 can be suppressed, and reduced coenzyme Q10 can be stably maintained by the co-presence of a licorice hydrophobic extract and reduced coenzyme Q10. In addition, reduced coenzyme Q10 can be produced by the co-presence of oxidized coenzyme Q10 and a licorice hydrophobic extract.

  本发明提供了一种还原型辅酶 Q10 的稳定化方法，可用于食品、声称具有营养功能的食品、特定保健用途食品、营养补充剂、营养补充品、动物药品、饮料、饲料、化妆品、医药产品、治疗药物、预防药物等，以及稳定化组合物。此外，本发明还提供了一种以氧化辅酶 Q10 为起始原料的还原型辅酶 Q10 的便捷生产方法。在本发明中，通过甘草疏水提取物和还原型辅酶Q10的共存，可以抑制还原型辅酶Q10的氧化，并稳定地维持还原型辅酶Q10。此外，氧化型辅酶 Q10 和甘草疏水提取物共存可产生还原型辅酶 Q10。

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