4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine | 960299-44-9

分子结构分类

有机化合物 - 有机氧化合物

中文名称

——

中文别名

——

英文名称

4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine

英文别名

4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline；4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinoline；4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-[4-(3-morpholinopropoxy)]quinoline；4-(3-(4-(2-Fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yloxy)propyl)morpholine；4-[3-[4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl]oxypropyl]morpholine

4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine化学式

CAS

960299-44-9

化学式

C₂₃H₂₄FN₃O₆

mdl

——

分子量

457.458

InChiKey

IOLICGLKOXEGOP-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

594.0±50.0 °C(Predicted)
密度：

1.310±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3.6
重原子数：

33
可旋转键数：

8
环数：

4.0
sp3杂化的碳原子比例：

0.35
拓扑面积：

98.9
氢给体数：

0
氢受体数：

9

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
4-(2-氟-4-硝基苯氧基)-6-甲氧基-7-(苄氧基)喹啉	7-benzyloxy-4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinoline	479690-03-4	C₂₃H₁₇FN₂O₅	420.397
6-甲氧基-7-[3-(4-吗啉基)丙氧基]-4(1H)-喹啉酮	6-methoxy-7-(3-morpholinopropoxy)quinolin-4-ol	205448-38-0	C₁₇H₂₂N₂O₄	318.373
4-氯-6-甲氧基-7-(3-吗啉丙氧基)喹啉	4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline	205448-32-4	C₁₇H₂₁ClN₂O₃	336.818

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline	479690-10-3	C₂₃H₂₆FN₃O₄	427.476
——	(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(benzylidene)semicarbazide	1428787-49-8	C₃₁H₃₂FN₅O₅	573.624
——	(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-fluorobenzylidene)semicarbazide	1449763-21-6	C₃₁H₃₁F₂N₅O₅	591.614
——	(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-chlorobenzylidene)semicarbazide	1449763-22-7	C₃₁H₃₁ClFN₅O₅	608.069
——	(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethylbenzylidene)semicarbazide	1449763-25-0	C₃₂H₃₁F₄N₅O₅	641.622
——	(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethoxybenzylidene)semicarbazide	1449763-23-8	C₃₂H₃₁F₄N₅O₆	657.622
——	N-(4-(7-(3-morpholinopropoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2-(pyridin-2-yl)acetamide	——	C₃₀H₃₁FN₄O₅	546.598
N-[3-氟-4-[[6-甲氧基-7-[[3-(吗啉-4-基)丙基]氧]喹啉-4-基]氧]苯基]-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺	foretinib	849217-64-7	C₃₄H₃₄F₂N₄O₆	632.664
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2-oxopyrrolidine-3-carboxamide	——	C₂₈H₃₁FN₄O₆	538.576
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-1-methyl-2-oxopyrrolidine-3-carboxamide	——	C₂₉H₃₃FN₄O₆	552.603
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)quinoline-8-carboxamide	——	C₃₃H₃₁FN₄O₅	582.631
——	2,5-difluoro-N-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yloxy]phenyl}benzenesulfonamide	1192300-40-5	C₂₉H₂₈F₃N₃O₆S	603.619
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-phenylpicolinamide	1491141-94-6	C₃₅H₃₃FN₄O₅	608.669
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-(4-fluorophenyl)picolinamide	1491141-97-9	C₃₅H₃₂F₂N₄O₅	626.66
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-p-tolylpicolinamide	1491141-95-7	C₃₆H₃₅FN₄O₅	622.696
——	cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide	849221-53-0	C₃₄H₃₅FN₄O₆	614.674
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxamide	——	C₃₃H₃₈FN₃O₆	591.68
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-(4-methoxyphenyl)picolinamide	1491142-00-7	C₃₆H₃₅FN₄O₆	638.696
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-phenylpyrimidine-2-carboxamide	1491142-23-4	C₃₄H₃₂FN₅O₅	609.657
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-(4-(trifluoromethyl)phenyl)picolinamide	1491141-99-1	C₃₆H₃₂F₄N₄O₅	676.667
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide	——	C₃₅H₃₆F₂N₄O₆	646.691
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-(4-fluorophenyl)pyrimidine-2-carboxamide	1491142-25-6	C₃₄H₃₁F₂N₅O₅	627.647
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-o-tolylpicolinamide	1491141-96-8	C₃₆H₃₅FN₄O₅	622.696
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-(2-fluorophenyl)picolinamide	1491141-98-0	C₃₅H₃₂F₂N₄O₅	626.66
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-p-tolylpyrimidine-2-carboxamide	1491142-24-5	C₃₅H₃₄FN₅O₅	623.684
——	N-{3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yloxy]phenyl}-2-trifluoromethylbenzenesulfonamide	1192300-38-1	C₃₀H₂₉F₄N₃O₆S	635.636
——	N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-(3-furyl)benzenesulfonamide	1558011-46-3	C₃₃H₃₂FN₃O₇S	633.697
——	N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-(1-methyl-1H-pyrazol-4-yl)benzenesulfonamide	1558011-47-4	C₃₃H₃₄FN₅O₆S	647.727
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2,3'-bipyridin-2'-amine	——	C₃₃H₃₂FN₅O₄	581.647
——	N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-4-(2,4-dimethoxyphenyl)picolinamide	1491142-01-8	C₃₇H₃₇FN₄O₇	668.722