(5R)-2,6-dimethyl-5-isopropenylcyclohex-2-en-1-one | 126254-47-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5R)-2,6-dimethyl-5-isopropenylcyclohex-2-en-1-one
• 英文别名: 6-methylcarvone；2,6-dimethyl-5-prop-1-en-2-ylcyclohex-2-en-1-one
• CAS: 126254-47-5
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: HDVXRNIZHQRLBD-UHFFFAOYSA-N

物化性质

• 沸点：
  241.5±35.0 °C(Predicted)
• 密度：
  0.913±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (5R)-2,6-dimethyl-5-isopropenylcyclohex-2-en-1-one 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 13.5h， 生成
  参考文献：
  名称：

  FeCl₃ Catalyzed Prins-Type Cyclization for the Synthesis of Highly Substituted Indenes: Application to the Total Synthesis of (±)-Jungianol and epi-Jungianol

  摘要：

  A novel approach was developed for the synthesis of highly substituted indene derivatives, using an FeCl3 catalyzed Prins-type cyclization reaction which was further applied in the total synthesis of jungianol and epi-jungianol.

  DOI：

  10.1021/ol3032347
• 作为产物：
  描述：

  香芹酮 、 碘甲烷 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 7.5h， 以82%的产率得到(5R)-2,6-dimethyl-5-isopropenylcyclohex-2-en-1-one
  参考文献：
  名称：

  FeCl₃ Catalyzed Prins-Type Cyclization for the Synthesis of Highly Substituted Indenes: Application to the Total Synthesis of (±)-Jungianol and epi-Jungianol

  摘要：

  A novel approach was developed for the synthesis of highly substituted indene derivatives, using an FeCl3 catalyzed Prins-type cyclization reaction which was further applied in the total synthesis of jungianol and epi-jungianol.

  DOI：

  10.1021/ol3032347

文献信息

• Hydroanthracene based compounds as anticancer agents
  申请人：DABUR RESEARCH FOUNDATION

  公开号：US20040220197A1

  公开（公告）日：2004-11-04

  The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.

  这项发明涉及使用新型基于蒽的化合物来抑制或预防癌细胞的生长或增殖，并涉及含有这种化合物的治疗组合物。该发明更具体地涉及使用基于羟基蒽的化合物来抑制和/或预防结肠、胰腺、前列腺、肺、喉、卵巢、乳腺、胶质母细胞瘤、口腔、内皮细胞和白血病的癌症。该发明的药剂形成一种独特的类别，与蒽、蒽醌或蒽醌衍生物不同。
• Vinyl sulfone bicycloannulation of cyclohexenones: one-step synthesis of tricyclo[3.2.1.02,7]octan-6-ones
  作者：Robert M. Cory、Richard M. Renneboog

  DOI：10.1021/jo00195a005

  日期：1984.10
• Bisannelation with Vinylselenoxide: Synthesis of Tricyclo[3.2.1.02,7]octane-6-one and its Congeners
  作者：Hisahiro Hagiwara、Hitoshi Sakai、Miki Kirita、Takashi Hoshi、Toshio Suzuki、Masayoshi Ando

  DOI：10.1016/s0040-4020(00)00032-6

  日期：2000.3

  Reaction of kinetic enolate of alpha'-substituted cyclohexenone derivatives with vinylselenoxides provided tricyclo[3.2.1.0(2.7)]-octane-6-one derivatives via domino Michael-Michael-substitution protocol. (C) 2000 Elsevier Science Ltd. All rights reserved.
• HYDROANTHRACENE BASED COMPOUNDS AS ANTICANCER AGENTS
  申请人：Dabur Research Foundation

  公开号：EP1620381A1

  公开（公告）日：2006-02-01
• US6051590A
  申请人：——

  公开号：US6051590A

  公开（公告）日：2000-04-18