tert-butyl 3(RS),7-dimethyl-6-octenoate | 208521-46-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: tert-butyl 3(RS),7-dimethyl-6-octenoate
• 英文别名: tert-butyl 3,7-dimethyloct-6-enoate
• CAS: 208521-46-4
• 化学式: C₁₄H₂₆O₂
• 分子量: 226.359
• InChiKey: OZDVQVVZYCLOIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tert-butyl 3(RS),7-dimethyl-6-octenoate 在 potassium permanganate 、 溶剂黄146 作用下， 以 乙醚 、 丙酮 为溶剂， 生成 6,7-Dihydroxy-3,6,7-trimethyl-octanoic acid tert-butyl ester
  参考文献：
  名称：

  Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

  摘要：

  Use of a resin bound diol as a boronic acid protecting group has been developed to allow the parallel synthesis of potent inhibitors of the hepatitis C virus NS3 serine proteinase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00284-5
• 作为产物：
  描述：

  3,7-二甲基-6-辛烯酸 、 异丁烯 在 硫酸 作用下， 以 二氯甲烷 为溶剂， 以81%的产率得到tert-butyl 3(RS),7-dimethyl-6-octenoate
  参考文献：
  名称：

  Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

  摘要：

  Use of a resin bound diol as a boronic acid protecting group has been developed to allow the parallel synthesis of potent inhibitors of the hepatitis C virus NS3 serine proteinase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00284-5

文献信息

• Peptidyl inhibitors of viral proteases
  申请人：Hoffmann-La Roche Inc.

  公开号：US05866684A1

  公开（公告）日：1999-02-02

  The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ; R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl; R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; and R.sup.3 represents hydrogen or lower alkyl; or R.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy; R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl; R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl; R.sup.6 represents hydrogen or lower alkyl; R.sup.7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl; R.sup.8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; and R.sup.9 represents lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower al koxycarbonyl, and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.

  该发明提供了公式##STR1##的氨基酸衍生物，其中E代表CHO或B(OH).sub.2；R.sup.1代表较低的烷基（可选择地被卤素、氰基、较低的烷基硫、芳基-较低的烷基硫、芳基或杂环芳基取代），较低的烯基或较低的炔基；R.sup.2代表较低的烷基，可选择地被羟基、羧基、芳基、氨基甲酰或较低的环烷基取代；R.sup.3代表氢或较低的烷基；或R.sup.2和R.sup.3一起代表可选择地被羟基取代的二甲基或三甲基；R.sup.4代表较低的烷基（可选择地被羟基、较低的环烷基、羧基、芳基、较低的烷基硫、氰基-较低的烷基硫或芳基-较低的烷基硫取代）、较低的烯基、芳基或较低的环烷基；R.sup.5代表较低的烷基（可选择地被羟基、较低的烷基硫、芳基、芳基-较低的烷基硫或氰基-较低的烷基硫取代）或较低的环烷基；R.sup.6代表氢或较低的烷基；R.sup.7代表较低的烷基（可选择地被羟基、羧基、芳基或较低的环烷基取代）或较低的环烷基；R.sup.8代表较低的烷基，可选择地被羟基、羧基或芳基取代；R.sup.9代表较低的烷基羰基、羧基-较低的烷基羰基、芳基羰基、较低的烷基磺酰基、芳基磺酰基、较低的烷氧羰基或芳基-较低的烷氧羰基，以及公式I的酸性化合物与碱形成的盐，这些化合物是病毒蛋白酶抑制剂，可用作抗病毒剂，特别是用于治疗或预防由丙型肝炎病毒、G型肝炎病毒和人类GB病毒引起的感染。
• Antiviral medicaments
  申请人：Hoffmann-La Roche Inc.

  公开号：US06372883B1

  公开（公告）日：2002-04-16

  The invention is concerned with amino acid derivatives of the formula and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.

  这项发明涉及公式的氨基酸衍生物和公式I的酸性化合物与碱的盐，这些是病毒蛋白酶抑制剂，可用作抗病毒剂，特别用于治疗或预防由丙型肝炎病毒、G型肝炎病毒和人类GB病毒引起的感染。
• Insect repellent compounds and compositions, and methods thereof
  申请人：Iowa State University Research Foundation, Inc.

  公开号：US11485701B2

  公开（公告）日：2022-11-01

  The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or compositions.

  本发明涉及含单萜类和苯丙类衍生物的化合物、制造这些化合物的方法、包含这些化合物的组合物以及使用这些化合物和/或组合物驱除害虫的方法。
• US06018020
  申请人：——

  公开号：——

  公开（公告）日：——
• ANTIVIRAL PEPTIDE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0941233A2

  公开（公告）日：1999-09-15