6,7-Dihydroxy-3,6,7-trimethyl-octanoic acid tert-butyl ester | 244302-62-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6,7-Dihydroxy-3,6,7-trimethyl-octanoic acid tert-butyl ester
• 英文别名: Tert-butyl 6,7-dihydroxy-3,6,7-trimethyloctanoate；tert-butyl 6,7-dihydroxy-3,6,7-trimethyloctanoate
• CAS: 244302-62-3
• 化学式: C₁₅H₃₀O₄
• 分子量: 274.401
• InChiKey: MVDZXSOZYNAADT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6,7-Dihydroxy-3,6,7-trimethyl-octanoic acid tert-butyl ester 以 四氢呋喃 为溶剂， 生成 5-[2-(1-Chloro-propyl)-4,5,5-trimethyl-[1,3,2]dioxaborolan-4-yl]-3-methyl-pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

  摘要：

  Use of a resin bound diol as a boronic acid protecting group has been developed to allow the parallel synthesis of potent inhibitors of the hepatitis C virus NS3 serine proteinase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00284-5
• 作为产物：
  描述：

  tert-butyl 3(RS),7-dimethyl-6-octenoate 在 potassium permanganate 、 溶剂黄146 作用下， 以 乙醚 、 丙酮 为溶剂， 生成 6,7-Dihydroxy-3,6,7-trimethyl-octanoic acid tert-butyl ester
  参考文献：
  名称：

  Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

  摘要：

  Use of a resin bound diol as a boronic acid protecting group has been developed to allow the parallel synthesis of potent inhibitors of the hepatitis C virus NS3 serine proteinase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00284-5

文献信息

• Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase
  作者：Rachel M Dunsdon、John R Greening、Philip S Jones、Steven Jordan、Francis X Wilson

  DOI：10.1016/s0960-894x(00)00284-5

  日期：2000.7

  Use of a resin bound diol as a boronic acid protecting group has been developed to allow the parallel synthesis of potent inhibitors of the hepatitis C virus NS3 serine proteinase. (C) 2000 Elsevier Science Ltd. All rights reserved.