5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid | 16915-32-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid
• 英文别名: 5-Isopropyl-3,8-dimethyl-azulen-1-sulfonsaeure；Guajazulen-sulfonsaeure-(3)；Guajazulen-3-sulfonsaeure；Gualenic acid；3,8-dimethyl-5-propan-2-ylazulene-1-sulfonic acid
• CAS: 16915-32-5
• 化学式: C₁₅H₁₈O₃S
• 分子量: 278.372
• InChiKey: VIZXMHCBZLGUET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid 在 sodium hydroxide 作用下， 生成 sodium gualenate
  参考文献：
  名称：

  Synthesis and antigastric ulcer activity of novel 5-isoproyl-3,8-dimethylazulene derivatives

  摘要：

  5-Isoproyl-3,8-dimethylazulene derivatives were synthesized and evaluated for antigastric ulcer activity in vivo. Some of them possess the best activity against gastric ulcer with ulcer index values lower than the drug reference (omeprazole). The structure-activity relationship (SAR) shows that the lipophilic flat structure contributes to quite potent antigastric ulcer activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.018
• 作为产物：
  描述：

  愈创奥 在 dioxane-SO₃ 、 1,2-二氯乙烷 作用下， 生成 5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid
  参考文献：
  名称：

  Treibs; Schroth, Justus Liebigs Annalen der Chemie, 1954, vol. 586, p. 202,207

  摘要：

  DOI：

文献信息

• N-SUBSTITUTED ISOPROPYLDIMETHYL AZULENE SULFONAMIDE DERIVATIVES, AND PREPARATION METHOD AND USE THEREOF
  申请人：Zhang Luyun

  公开号：US20140206741A1

  公开（公告）日：2014-07-24

  The present invention provides an N-substituted isopropyldimethyl azulene sulfonamide derivative as represented by formula (I), and preparation method and uses thereof, wherein R1 is an alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, amino, or a substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and amino. The N-substituted isopropyldimethyl azulene sulfonamide derivative can be used in treating gastric ulcer.

  本发明提供了一种N-取代异丙基二甲基蓝烯磺胺衍生物，其化学式表示为(I)，以及其制备方法和用途，其中R1是烷基、环烷基、烯基、炔基、芳基、杂环芳基、氨基或取代的烷基、环烷基、烯基、炔基、芳基、杂环芳基和氨基。N-取代异丙基二甲基蓝烯磺胺衍生物可用于治疗胃溃疡。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Film applicable to oral mucosa and drug preparation comprising the same
  申请人：NITTO DENKO CORPORATION

  公开号：EP0381193A2

  公开（公告）日：1990-08-08

  A soft film applicable to the oral mucosa and a drug preparation comprising said film are disclosed, the film comprising a homogeneous mixture comprising a vinyl acetate homopolymer, an acrylic acid polymer, and a cellulose derivative capable of being dissolved in or swollen with water and a lower alcohol. The film or preparation is less causative of an adverse feeling on application to the oral mucosa, excellent in shape retention on water absorption, and adhesive to the oral mucosa for an extended period of time.

  本发明公开了一种适用于口腔黏膜的软薄膜和一种包含所述薄膜的药物制剂，该薄膜由醋酸乙烯均聚物、丙烯酸聚合物和纤维素衍生物组成的均质混合物，能够溶于水或用水和低级醇溶胀。这种薄膜或制剂在口腔粘膜上使用时不易产生不良感觉，在吸水后具有良好的形状保持性，并能长时间粘附在口腔粘膜上。
• Method of hair treatment
  申请人：Kao Corporation

  公开号：EP0662314A1

  公开（公告）日：1995-07-12

  A method of hair treatment comprising applying a hair treating preparation to hair and treating the hair with steam either simultaneously with or after the application of the hair treating preparation, in which said hair treating preparation contains a nonvolatile compound selected from a monoalkyl ether of a polyalkylene glycol, a hydroxycarboxylic acid, a hydroxysulfonic acid, an aromatic sulfonic acid, and a nonionic amphiphilic compound.

  一种头发处理方法，包括在头发上涂抹一种头发处理制剂，并在涂抹头发处理制剂的同时或之后用蒸汽处理头发，其中所述头发处理制剂含有一种非挥发性化合物，该化合物选自聚亚烷基二醇单烷基醚、羟基羧酸、羟基磺酸、芳香族磺酸和非离子两性化合物。
• APPARATUS AND METHODS FOR OCULAR INJECTION
  申请人：Clearside Biomedical, Inc.

  公开号：EP3417896A2

  公开（公告）日：2018-12-26

  An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

  一种设备包括一个与药剂容器相连的外壳，药剂容器与针头相连。注射组件安装在外壳内，包括储能部件和驱动杆。致动杆的远端部分位于药剂容器内。储能部件可对驱动杆的近端部分产生足够的力，使驱动杆的远端部分在药剂容器内移动。这样，当针头的远端位于目标位置的第一区域内时，就可以通过针头从药剂容器中输送至少一部分物质。当针头的远端位于目标位置的第二区域内时，力不足以在药剂容器内移动致动杆的远端部分。