2-allylaminoquinoline | 204773-15-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-allylaminoquinoline
• 英文别名: N-prop-2-enylquinolin-2-amine
• CAS: 204773-15-9
• 化学式: C₁₂H₁₂N₂
• mdl: MFCD16661540
• 分子量: 184.241
• InChiKey: FVIPZFOXHOWPDW-UHFFFAOYSA-N

物化性质

• 沸点：
  330.1±17.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-allylaminoquinoline 在 palladium on activated charcoal 三氟化硼乙醚 作用下， 以 乙醇 为溶剂， 以71%的产率得到2-氨基喹啉
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2
• 作为产物：
  描述：

  2-溴喹啉 、 丙烯胺 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 1,1'-双(二苯基膦)二茂铁 、 sodium t-butanolate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以76%的产率得到2-allylaminoquinoline
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2

文献信息

• One-pot synthesis of α-aminophosphonates via a cascade sequence of allylamine isomerization/hydrophosphonylation
  作者：Liu-Liang Mao、Chen-Chen Li、Qiang Yang、Ming-Xing Cheng、Shang-Dong Yang

  DOI：10.1039/c7cc01391d

  日期：——

  A Rh/Ni-catalyzed cascade sequence of allylamine isomerization and hydrophosphonylation to synthesize [small alpha]-aminophosphonates has been disclosed.

  已经公开了Rh / Ni催化的烯丙胺异构化和氢膦酰化以合成α-氨基膦酸酯的级联序列。
• Hybrid molecules QA, wherein Q is an aminoquinoline and a is an antibiotic or a resistance enzyme inhibitor, their synthesis and their uses as antibacterial agent
  申请人：Sanchez Muriel

  公开号：US20060025327A1

  公开（公告）日：2006-02-02

  Aminoquinoline-antibiotic hybrid compounds in the form of hybrid molecules QA, wherein Q is an aminoquinoline and A is an antibiotic or a resistance enzyme inhibitor, their synthesis and their uses as antibacterial agent. This compound is defined by the general formula (I): Q-(Y 1 ) p —(U) p′ —(Y 2 ) p″ -A  (I) in which Q represents an aminoquinoline, (Y 1 ) p —(U) p′ —(Y 2 ) p″ — is an optional spacer arm and A is an antibiotic, one of its derivatives or precursors, or a resistance enzyme inhibitor. The invention unexpectedly enables the activity of the antibiotic to be improved.

  氨基喹啉-抗生素混合物化合物以混合分子QA的形式存在，其中Q是氨基喹啉，A是抗生素或耐药酶抑制剂，它们的合成及用途作为抗菌剂。该化合物由通用公式(I)定义：Q-(Y1)p—(U)p′—(Y2)p″-A  (I)其中Q代表氨基喹啉，(Y1)p—(U)p′—(Y2)p″—为可选的间隔臂，A是抗生素、其衍生物或前体之一，或耐药酶抑制剂。该发明意外地能够改善抗生素的活性。
• [EN] USE OF POLYAMINOISOPRENYL DERIVATIVES IN ANTIBIOTIC OR ANTISEPTIC TREATMENT<br/>[FR] UTILISATION DE DÉRIVÉS DE POLYAMINO-ISOPRÉNYLE DANS UN TRAITEMENT ANTIBIOTIQUE OU ANTISEPTIQUE
  申请人：UNIV AIX MARSEILLE

  公开号：WO2012113891A1

  公开（公告）日：2012-08-30

  The present invention relates to the use of polyaminoisoprenylderivatives in antibiotic or antiseptic treatment of bacteria including those presentingmultiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenylderivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.

  本发明涉及在抗生素或抗菌剂治疗细菌中使用聚氨基异戊烯衍生物，包括那些表现出多重耐药性（MDR）的细菌，特别是作为外排泵抑制剂。它还涉及新型聚氨基异戊烯衍生物，包括它们的组合物，制备它们的方法，以及在抗生素或抗菌剂治疗中使用它们的方法。
• Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation
  申请人：——

  公开号：US20030216431A1

  公开（公告）日：2003-11-20

  The present invention relates to novel ophthalmic pharmaceutical compositions comprising an inflammation-treating amount of a 4-aminoquinoline compound, derivative, isomers, or chemical salts, and methods for using these compositions for the treatment of ocular inflammatory conditions by topical administration directly to the eye.

  本发明涉及一种新型眼科药物组合物，包括一定量的4-氨基喹啉化合物、衍生物、异构体或化学盐，用于通过直接局部给药于眼睛治疗眼部炎症状况的方法。
• Novel pyrimidine derivatives and methods of making and using these derivatives
  申请人：——

  公开号：US20020052384A1

  公开（公告）日：2002-05-02

  This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in immunocompromised patients. The compounds themselves, methods of making these compounds, and methods of using these compounds are all disclosed.

  本发明披露了嘧啶衍生物及其药学上可接受的盐和前药，用于治疗患有疾病的患者的治疗和/或预防。这种疾病包括癌症和免疫功能受损的患者因肺孢子菌和弓形虫感染而引起的继发感染。本发明披露了这些化合物本身，制备这些化合物的方法以及使用这些化合物的方法。