tubuloside A | 112516-05-9

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tubuloside A
• 英文别名: [(2R,3R,4S,5R,6R)-5-acetyloxy-6-[2-(3,4-dihydroxyphenyl)ethoxy]-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• CAS: 112516-05-9
• 化学式: C₃₇H₄₈O₂₁
• 分子量: 828.776
• InChiKey: KZLDMAIXPXOZCX-BBQAUMBQSA-N

物化性质

• 沸点：
  1045.5±65.0 °C(Predicted)
• 密度：
  1.62±0.1 g/cm3 (20 ºC 760 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  58
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  331
• 氢给体数：
  11
• 氢受体数：
  21

制备方法与用途

生物活性

Tubuloside A 是一种具有抗氧化活性和保肝活性的苯乙醇苷。体外研究显示，Tubuloside A (8.6 μM) 能够抑制由D-GalN引起的肝细胞死亡。

化学性质

Tubuloside A 为白色结晶粉末，可溶于甲醇、乙醇和DMSO等有机溶剂。它来源于列当科管花肉苁蓉（Cistanche tubulosa (Scgrenk) R. Wight）。

用途

用于含量测定、鉴定及药理实验等。原药材具有补肾阳、益精血的功效。

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 tubuloside A 在 吡啶 作用下， 生成 echinacoside dodecaacetate
  参考文献：
  名称：

  Kobayashi, Hiromi; Oguchi, Hiroko; Takizawa, Nobuo, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 8, p. 3309 - 3314

  摘要：

  DOI：

文献信息

• COSMETIC COMPOSITION AND PREPARATION METHOD AND USE THEREOF
  申请人：Wang, Hailong

  公开号：EP2080506A1

  公开（公告）日：2009-07-22

  A skin-whitening, freckle-removing cosmetic composition, comprising an effective amount of extract from Cistanche deserticola and other useful adjuvants.

  一种美白祛斑化妆品组合物，包含有效量的肉苁蓉提取物和其他有用的佐剂。
• USE OF CISTANCHE TUBULOSA EXTRACT IN THE PREPARATION OF DRUGS OR FOODS FOR PROTECTING OCULAR CELLS
  申请人：Sinphar Tian-li Pharmaceutical Co., Ltd. (Hangzhou)

  公开号：EP3181143A1

  公开（公告）日：2017-06-21

  This invention provides a method of using extract of Cistanche tubulosa. The extract was used to prepare drugs or food for protecting eye cells. The extract has a good protective effect for eye cells, and can be further developed to drugs or food for preventing eye disease or slow downing the progress of eye disease.

  本发明提供了一种使用肉苁蓉提取物的方法。该提取物用于制备保护眼部细胞的药物或食品。该提取物对眼部细胞具有良好的保护作用，可进一步开发成预防眼部疾病或延缓眼部疾病进展的药物或食品。
• Method of using Cistanche tubulosa extract to prevent, slow down, or treat an eye disease caused by oxidative stress
  申请人：Sinphar Pharmaceutical Co., Ltd.

  公开号：US10967029B2

  公开（公告）日：2021-04-06

  This invention provides a method of using extract of Cistanche tubulosa. The extract was used to prevent, slow down, or treat an eye disease caused by oxidative stress. The method includes administrating to a subject in need a therapeutically effective amount of the extract of Cistanche tubulosa to prevent, slow down, or treat an eye disease caused by oxidative stress.

  本发明提供了一种使用肉苁蓉提取物的方法。该提取物用于预防、减缓或治疗由氧化应激引起的眼部疾病。该方法包括向有需要的受试者施用治疗有效量的肉苁蓉提取物，以预防、减缓或治疗由氧化应激引起的眼病。
• Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same
  申请人：Sinphar Pharmaceutical Co., Ltd.

  公开号：US20040162246A1

  公开（公告）日：2004-08-19

  The body of a herbaceous plant, Cistanche tubulosa (Schenk.) Wight, is used to make a medicinal preparation containing phenylethanoid glycosides and comprising 10-70% of echinacoside by weigh of the preparation and 1-40% of acteoside by weight of the preparation. The medicinal preparation is used as an active ingredient of medicinal composition for use in prevention of senile dementia, and inhibition of aggregation of blood platelets.

  草本植物的身体、 肉苁蓉 (Schenk.)Wight)的身体，用于制造一种含有苯乙醇苷的药用制剂，按制剂重量计，其中包括 10-70% 的棘鲷苷和 1-40% 的槲皮苷。该药剂可作为药物组合物的活性成分，用于预防老年痴呆症和抑制血小板聚集。
• Composition comprising the extract of cistanche deserticola Y.C. MA showing enhancing activity of the neurite outgrowth and neurotrophic effects
  申请人：KYUNG HEE UNIVERSITY

  公开号：US20040219233A1

  公开（公告）日：2004-11-04

  The present invention relates to a composition comprising an extract of Cistanche deserticola Y. C. having nerve growth factor (NGF) similar activity for the prevention and treatment of neuronal degenerative brain disease. The extracts from Cistanche deserticola have potent neuronal cell protective activity by promoting neurite outgrowth and acting as a NGF therefore it can be used as the therapeutics or health food for treating and preventing neuro-degenerative brain diseases.

  本发明涉及一种组合物，该组合物包含以下物质的提取物 肉苁蓉 Y.C. 的提取物，该提取物具有类似神经生长因子（NGF）的活性，可用于预防和治疗神经元退行性脑病。 肉苁蓉提取物 肉苁蓉提取物 肉苁蓉提取物具有强大的神经元细胞保护活性，能促进神经元突起生长，起到神经生长因子的作用，因此可用作治疗和预防脑神经退行性疾病的药物或保健食品。