sodium D-glucoronate | 14984-34-0

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sodium D-glucoronate
• 英文别名: sodium D-glucuronate；D-glucuronic acid sodium salt；D-glucuronic acid ; sodium-salt；D-Glucuronsaeure; Natrium-Salz；sodium glucuronate；sodium;(2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate
• CAS: 14984-34-0
• 化学式: C₆H₉O₇*Na
• 分子量: 216.123
• InChiKey: WNFHGZLVUQBPMA-JSCKKFHOSA-M

物化性质

• 熔点：
  138 °C (dec.)(lit.)
• 稳定性/保质期：

  常温常压下稳定，避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -7.62
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  7

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2918990090
• RTECS号：
  LZ8950000
• 储存条件：
  常温密闭避光，存于通风干燥处。

SDS

Name:	d-Glucuronic acid sodium salt monohydrate 99% Material Safety Data Sheet
Synonym:	Non
CAS:	14984-34-0

Section 1 - Chemical Product MSDS Name:d-Glucuronic acid sodium salt monohydrate 99% Material Safety Data Sheet
Synonym:Non

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
14984-34-0	D-Glucuronic acid, sodium salt, monohy	99.0	239-065-7

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. No information regarding eye irritation and other potential effects was found.
Skin:
No information regarding skin irritation and other potential effects was found.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 14984-34-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: colorless or white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: @ 760.00mm Hg
Freezing/Melting Point: 138 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H9O7Na.H2O
Molecular Weight: 234.14

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
None reported.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 14984-34-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
D-Glucuronic acid, sodium salt, monohydrate - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 14984-34-0: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 14984-34-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 14984-34-0 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

制备方法

用于肝脏疾患的辅助治疗以及用于食物解毒等。

用途简介 用途

用于肝脏疾患的辅助治疗以及用于食物解毒等。

反应信息

• 作为反应物：
  描述：

  sodium D-glucoronate 在 aldose reductase from the medulla of rat kidney 、 还原型辅酶II(NADPH)四钠盐 作用下， 以 水 为溶剂， 生成 L-古洛糖酸
  参考文献：
  名称：

  Characterization of aldose reductase and aldehyde reductase from the medulla of rat kidney.

  摘要：

  大鼠肾髓质中的醛糖还原酶和醛还原酶通过亲和层析、凝胶过滤和色谱聚焦法被纯化至均一状态。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定，醛糖还原酶和醛还原酶的分子量分别为37000和39000。通过色谱聚焦法测定，醛糖还原酶和醛还原酶的等电点分别为5.4和6.2。两种酶在氨基酸组成上的主要差异在于丝氨酸、丙氨酸和天冬氨酸。底物特异性研究表明，醛糖还原酶利用aldo糖如D-葡萄糖和D-半乳糖，而醛还原酶不使用它们。醛糖还原酶对各种底物的Km值低于醛还原酶。醛糖还原酶利用还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和还原型烟酰胺腺嘌呤二核苷酸（NADH）作为辅酶，而醛还原酶仅利用NADPH。硫酸离子的存在显著激活了醛糖还原酶，而对醛还原酶活性无影响。这些酶受到已知的醛糖还原酶抑制剂的强烈抑制。然而，醛糖还原酶比醛还原酶对醛糖还原酶抑制剂的抑制作用更为敏感。

  DOI：

  10.1248/cpb.38.1639

文献信息

• [EN] COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT ET/OU LES SOINS DE LA PEAU, DES CHEVEUX, DES ONGLES ET/OU DES MUQUEUSES
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2019008452A1

  公开（公告）日：2019-01-10

  A compound of formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2 wherein AA1 is Phe; AA2 is Trp; AA3 is selected from the group consisting of Met, Leu and lie; AA4 is selected from the group consisting of Lys, Arg and Gin; AA5 is Arg; AA6 is Lys; AA7 is selected from the group consisting of Arg, Lys and His; AA8 is selected from the group consisting of Val, lie, Leu and Met; and AA9 is Pro, useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energising the skin and as an anti- aging agent.

  一种具有以下结构的化合物（I）R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2，其中AA1为Phe；AA2为Trp；AA3选自Met、Leu和Ile组成的群体；AA4选自Lys、Arg和Gln组成的群体；AA5为Arg；AA6为Lys；AA7选自Arg、Lys和His组成的群体；AA8选自Val、Ile、Leu和Met组成的群体；AA9为Pro。该化合物在治疗和/或护理皮肤、头发、指甲和/或粘膜方面具有用途，特别用于改善皮肤的屏障功能，激活皮肤并作为抗衰老剂。
• Regimens for intra-articular viscosupplementation
  申请人：Bailleul Francois

  公开号：US20060148755A1

  公开（公告）日：2006-07-06

  The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc®) is administered in a single intra-articular knee injection of 6±2 ml.

  该发明提供了使用基于透明质酸的粘液补充剂治疗骨关节炎和关节损伤的方法，特别是具有关节内半衰期短于3周的粘液补充剂。用于该发明方法的粘液补充剂可能进一步具有以下特征：含有少于20毫克/毫升的透明质酸，其中至少5%（重量/重量）为凝胶形式，例如hylan B。在一个说明性实施例中，hylan G-F 20（Synvisc®）以单次关节内注射6±2毫升的方式给予。
• Topical and oral formulations of cardiac glycosides for treating skin diseases
  申请人：Streeper Robert

  公开号：US20060205679A1

  公开（公告）日：2006-09-14

  The present invention provides method, preparation and use of a variety of pharmaceutical compositions containing at least one digitalis glycoside such as oleandrin, odoroside-A, neriifolin, proscillaridin-A, methyl-proscillaridin-A, digitoxin, digoxin alone or at least one digitalis glycoside complexed with cyclodextrins. In another aspect, the present invention provides an effective method to treat diseases in mammals. In yet another aspect, the present invention provides an effective method for treating skin diseases in a human or non-human animal.

  本发明提供了一种方法、制备和使用多种含有至少一种毛地黄苷类药物成分的药物组合物，例如奥利安定、奥多罗苷A、内里福林、普罗斯西拉里丁A、甲基普罗斯西拉里丁A、地高辛、地高辛或至少一种毛地黄苷类与环糊精络合的药物。另一方面，本发明提供了一种有效的方法来治疗哺乳动物的疾病。另一方面，本发明提供了一种有效的方法来治疗人类或非人类动物的皮肤疾病。
• [EN] COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT ET/OU LE SOIN DE LA PEAU, DES CHEVEUX, DES ONGLES ET/OU DES MUQUEUSES
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2018102508A1

  公开（公告）日：2018-06-07

  A compound of formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-(AA7)a-(AA8)b-Yp-Zq-R2 effective in maintaining and/or improving the physical and immunological barrier functions of the skin and useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes.

  化合物的化学式（I）为R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-(AA7)a-(AA8)b-Yp-Zq-R2，有效地维护和/或改善皮肤的物理和免疫屏障功能，并且在皮肤、头发、指甲和/或粘膜的治疗和/或护理中有用。
• [EN] PROCESSES FOR THE PRODUCTION OF XYLITOL<br/>[FR] PROCEDES DE PRODUCTION DE XYLITOL
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2005095314A1

  公开（公告）日：2005-10-13

  Methods of producing xylitol comprising the oxidative decarboxylation of a reactant substrate are provided herein. The oxidative decarboxylation is performed in one of two ways. In the first, the oxidative decarboxylation is performed by an electrochemical process, preferably an anodic odixative decarboxylation of a reactant substrate. In the second, the oxidative decarboxylation of the reactant substrate is carried out by a series of oxidation-reduction chemical reactions.

  本文提供了一种生产木糖醇的方法，包括对反应底物进行氧化脱羧。氧化脱羧可以通过两种方式之一进行。在第一种方式中，氧化脱羧是通过电化学过程进行的，最好是对反应底物进行阳极氧化脱羧。在第二种方式中，对反应底物的氧化脱羧是通过一系列氧化还原化学反应进行的。

表征谱图