(1R,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2-carboxylic acid | 85954-57-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2-carboxylic acid
• 英文别名: bornanecarboxylic acid；(1R)-1,7,7-trimethyl-norbornane-2endo-carboxylic acid；(1R)-1,7,7-Trimethyl-norbornan-2endo-carbonsaeure；(1R)-1.7.7-Trimethyl-norbornan-carbonsaeure-(2endo)；endo-Bornan-2-carbonsaeure；(1R,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptane-2-carboxylic acid
• CAS: 85954-57-0
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: ZURRKVIQUKNLHF-DKCNOQQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2-carboxylic acid 在 chromium(VI) oxide 、 selenium(IV) oxide 、 硫酸 、 potassium tert-butylate 、 一水合肼 、 溶剂黄146 作用下， 以 甲醇 、 叔丁醇 为溶剂， 反应 105.33h， 生成 (1R,2R,4S)-5-[2-(2-fluoro-phenyl)-2-hydrazono-eth-(Z)-ylidene]-1,7,7-trimethyl-6-oxo-bicyclo[2.2.1]heptane-2-carboxylic acid methyl ester
  参考文献：
  名称：

  PYRIDAZINE DERIVATIVES AS RORc MODULATORS

  摘要：

  公式I的化合物：或其药用盐，其中X，Ar1，R1，R2，R3，R4，R5，R6和R7如本文所定义。还公开了制备这些化合物的方法，并将这些化合物用于治疗炎症性疾病，如关节炎。

  公开号：

  US20150126491A1
• 作为产物：
  描述：

  beta-pinene 在 盐酸 、 lithium-sodium alloy 作用下， 以 正戊烷 为溶剂， 反应 9.0h， 生成 (1R,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2-carboxylic acid
  参考文献：
  名称：

  2-Bornyllithium: preparation, characterization, and use in synthesis

  摘要：

  DOI：

  10.1021/jo00379a033

文献信息

• Rearrangement Approaches to Cyclic Skeletons. IX. Stereoselective Total Synthesis of (±)-Camphorenone Based on a Ring-Contraction of Bicyclo[3.2.1]oct-6-en-2-one. Reliable One-Step Diazo Transfer Followed by a Wolff Rearrangement
  作者：Tadao Uyehara、Naohiko Takehara、Masako Ueno、Toshio Sato

  DOI：10.1246/bcsj.68.2687

  日期：1995.9

  onyl azide and potassium t-butoxide at −78 °C in THF. A Wolff rearrangement of the resulting α-diazoketones in the presence of water gave ring-contraction products, bicyclo[2.2.1]heptenecarboxylic acids. Using these two transformations the total synthesis of (±)-camphorenone was achieved stereoselectively, starting from 1-methoxybicyclo[2.2.2]oct-5-en-2-one.

  双环[3.2.1]oct-6-en-2-ones和相关化合物的直接重氮转移反应是通过在-78°C的THF中用2,4,6-三异丙基苯磺酰基叠氮化物和叔丁醇钾处理来完成的。在水的存在下，所得α-重氮酮的沃尔夫重排得到环收缩产物，双环[2.2.1]庚烯羧酸。使用这两个转化，从 1-甲氧基双环 [2.2.2] oct-5-en-2-one 开始，立体选择性地实现了 (±)-樟脑酮的全合成。
• The Condensation of Camphene and Phenol. Product Formation <i>via</i> a Direct 2,6-Hydride Transfer
  作者：William F. Erman

  DOI：10.1021/ja01068a025

  日期：1964.7
• Gream,G.E. et al., Australian Journal of Chemistry, 1974, vol. 27, p. 603 - 628
  作者：Gream,G.E. et al.

  DOI：——

  日期：——
• de Botton, Annales de Chimie (Cachan, France), 1955, vol. <12> 10, p. 455,481
  作者：de Botton

  DOI：——

  日期：——
• Generation and control of tracer particles for optical flow investigations in air
  作者：C. Kähler、B. Sammler、J. Kompenhans

  DOI：10.1007/s00348-002-0492-x

  日期：2002.12

  The production of monodisperse tracer particles with suitable properties for optical flow investigations, such as small size, spherical shape, smooth surface, appropriate density and diffraction index, non-evaporating and agglomerating, electrically neutral, non-toxic and easily removable, is a challenging task due to the sensitivity of the particle size distribution to the boundary conditions. In order to obtain general design and operating rules for atomizers which are mostly applied for air flows, this dependence is investigated here. It is shown that high concentrations of narrow band particle size distributions, with a mean diameter below 1 mum, can easily be generated by means of multi-hole nozzles under over-critical pressure conditions, when the kinetic energy, transferred into the seeding liquid through the nozzle exits, is well balanced with the liquid volume inside the atomizer. In addition, flow visualization pictures are presented which permit a useful assessment of the functioning of the nozzles and reveal operating features of the atomizers which were not previously known. In particular, it is shown that existing explanations of the importance of certain design features of the Laskin nozzle are of minor importance for the generation of appropriate tracer particles.