octa-hydrogenated retinoic acid | 180603-01-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: octa-hydrogenated retinoic acid
• 英文别名: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid；3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nonanoic acid；3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nonanoic acid
• CAS: 180603-01-4
• 化学式: C₂₀H₃₆O₂
• 分子量: 308.505
• InChiKey: UPHFJVMAJPDXRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维A酸 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 、 环己烷 为溶剂， 反应 24.0h， 生成 octa-hydrogenated retinoic acid
  参考文献：
  名称：

  八氢视黄酸偶联的乙二醇壳聚糖纳米粒作为印za素的新型载体：合成，表征和体外评价

  摘要：

  环保和控释制剂对于减少环境污染和实现最有效的农药利用具有很高的前景。作为农药的新型“绿色”纳米载体，通过八氢化视黄酸（OR）与乙二醇壳聚糖（GC）骨架的化学偶联制备了两亲性自组装纳米颗粒。在水性介质中，合成的OR-GC共轭物形成直径为257 nm的纳米级颗粒。使用简单的透析方法将疏水性印za素（AZA）以高达1：4的进料重量比有效负载到OR-GC纳米颗粒中，其最大载药效率为74％。AZA-OR-GC（25 wt％）纳米颗粒还显示出所掺入的AZA的持续释放（65％的负载剂量在27°C的磷酸盐缓冲盐水（pH 7.2）中于7天释放）。细胞毒性试验和细胞周期停滞试验证实，OR-GC具有良好的生物相容性。与有机溶剂中的游离AZA相比，AZA-OR-GC（25 wt％）纳米颗粒还显示出对Sl-1细胞中细胞增殖的抑制作用。总体而言，控释AZA-OR-GC可能是一种有前途的环境友好型有害生物综合治理制剂。©2013

  DOI：

  10.1002/pola.26801

文献信息

• Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same
  申请人：Bordat Pascal

  公开号：US20100168045A1

  公开（公告）日：2010-07-01

  The invention concerns novel polyunsaturated compounds of formula (I) wherein: R 1 represents a R′ 1 , -A-R′ 1 group, R′ 1 being selected from —COOH, —COOR 3 , —CONH 2 , —CONHR 3 , —CONR 3 , R 4 , —CHO, —CH 2 OH, —CH 2 OR 5 , and A represents a C 2 -C 16 alkylene, alkenylene or alkynylene; R 2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH 2 )n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R′ 2 —O—R 6 group, wherein R′ 2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R 6 represents a hydrogen atom, a straight or branched optionally substituted C 1 -C 16 alkyl, a straight or branched optionally substituted C 2 -C 16 alkenyl, or a straight or branched C 2 -C 16 alkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

  本发明涉及一种新型多不饱和化合物，其化学式为(I)，其中：R1代表R′1、-A-R′1基团，R′1从-COOH、-COOR3、-CONH2、-CONHR3、-CONR3、R4、-CHO、-CH2OH、-CH2OR5中选择，A代表C2-C16烷基、烯基或炔基；R2代表：可选取取代芳基或可选取取代杂环芳基；糖残基或脂肪酸残基，可选取支链和/或取代基，优选在链末端特别是由羟基、乙酰氧基基团或可选保护的氨基基团取代的脂肪酸残基；-OC-(CH2)nCO-生育酚（α、β、γ或δ）基团，其中2≤n≤10；-R′2-O-R6基团，其中R′2为可选取取代芳烃基团或可选取取代杂环芳烃基团，R6代表氢原子、直链或支链的可选取代C1-C16烷基、直链或支链的可选取代C2-C16烯基或直链或支链的C2-C16炔基，可选取取代的生育酚基团或类似物、氨基酸残基或糖残基。本发明还涉及包含至少一种化合物(I)的组合物，特别是化妆品和/或皮肤科学组合物，以及它们作为美白和/或脱色剂的用途，以及使用所述组合物的美容方法。
• COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING siRNA ACTIVITY
  申请人：Niitsu Yoshiro

  公开号：US20130017249A1

  公开（公告）日：2013-01-17

  Here described are compounds consisting of the structure (targeting molecule) m -linker-(targeting molecule) n , wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

  这里描述的是由结构（靶向分子）m-连接物（靶向分子）n组成的化合物，其中靶向分子是一种视黄醇或脂溶性维生素，在靶细胞上具有特定的受体；其中m和n独立地为0、1、2或3；连接物包括聚乙二醇（PEG）或类似PEG的分子，以及包括这些化合物的组合物和药物制剂，用于治疗剂的靶向和传递；以及使用这些组合物和药物制剂的方法。
• COMPOSITION FOR REGENERATING NORMAL TISSUE FROM FIBROTIC TISSUE
  申请人：NITTO DENKO CORPORATION

  公开号：US20130171127A1

  公开（公告）日：2013-07-04

  The present invention relates to a pharmaceutical composition and a method for regenerating normal tissue from fibrotic tissue, the pharmaceutical composition and the method employing a collagen-reducing substance. In accordance with the present invention, normal tissue can be therapeutically regenerated from fibrotic tissue.

  本发明涉及一种药物组合物和一种从纤维化组织再生正常组织的方法，所述药物组合物和方法采用一种减少胶原蛋白的物质。根据本发明，可以通过治疗性地再生正常组织来从纤维化组织中再生出正常组织。
• DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS
  申请人：Nitto Denko Corporation

  公开号：US20130171240A1

  公开（公告）日：2013-07-04

  Disclosed is a stellate cell-specific drug carrier comprising a stellate cell-specific amount of a retinoid derivative and/or a vitamin A analogue, and a drug carrier component other than the retinoid derivative and/or a vitamin A analogue. Also disclosed in a medicine comprising the stellate cell-specific drug carrier, and a drug in an amount effective for controlling the activity or growth of stellate cells.

  本发明公开了一种星形细胞特异性药物载体，包括星形细胞特异性的视黄酸衍生物和/或维生素A类似物的量，以及除视黄酸衍生物和/或维生素A类似物以外的药物载体组分。同时公开了一种药物，包括星形细胞特异性药物载体和药物，药物的用量有效地控制星形细胞的活动或生长。
• TARGETING AGENT FOR CANCER CELL OR CANCER-ASSOCIATED FIBROBLAST
  申请人：Nitto Denko Corporation

  公开号：US20130210744A1

  公开（公告）日：2013-08-15

  Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid and/or derivative thereof; a substance delivery carrier for the cell, which comprises the targeting agent; an anti-cancer composition utilizing the targeting agent or the carrier; an anticancer-associated fibroblast composition; and a method for treatment of cancer.

  本发明涉及一种新的治疗剂和癌症的新治疗方法。具体涉及的是：一种针对癌细胞和癌相关成纤维细胞中所选细胞的靶向剂，包括维甲酸和/或其衍生物；一种用于该细胞的物质传递载体，包括靶向剂；一种利用靶向剂或载体的抗癌组合物；一种抗癌相关成纤维细胞组合物；以及一种癌症治疗方法。