di-n-propylfulvene | 17788-43-1

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: di-n-propylfulvene
• 英文别名: 6,6-dipropylfulvene；6,6-Dipropyl-fulven；Di-n-propylfulven；5-Heptan-4-ylidenecyclopenta-1,3-diene
• CAS: 17788-43-1
• 化学式: C₁₂H₁₈
• 分子量: 162.275
• InChiKey: RIOZNNXJCCJTTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  di-n-propylfulvene 以 N,N-二甲基乙酰胺 、 乙酸乙酯 为溶剂， 反应 16.33h， 生成
  参考文献：
  名称：

  Tuning the Hemolytic and Antibacterial Activities of Amphiphilic Polynorbornene Derivatives

  摘要：

  Amphiphilic cationic polynorbomene derivatives, soluble in water, were prepared from modular norbomene monomers, with a wide range of molecular weights (M-n = 1600-137 500 g/mol) and narrow polydispersities (PDI = 1.1-1.3). The antibacterial activity determined by growth inhibition assays and the hemolytic activity against human red blood cells were measured and compared to determine the selectivity of the polymers for bacterial over mammalian cells. The effects of monomer repeat unit hydrophobicity and polymer molecular weight on antibacterial and hemolytic activities were determined. The hydrophobicity of the repeat unit was observed to have dramatic effects on antibacterial and hemolytic activities. Lipid membrane disruption activities of the polymers was confirmed by measuring polymer-induced dye leakage from large unilamellar vesicles. By tuning the overall hydrophobicity of the polymer through random copolymerizations of modular norbomene derivatives, highly selective, nonhemolytic antibacterial activities were obtained. For appropriate monomer composition, selectivity against bacteria versus human red blood cells was determined to be over 100.

  DOI：

  10.1021/ja045664d
• 作为产物：
  描述：

  4-庚酮 、 环戊二烯 在 四氢吡咯 作用下， 以 甲醇 为溶剂， 以42%的产率得到di-n-propylfulvene
  参考文献：
  名称：

  通过有机光氧化还原催化的可见光诱导的 [4 + 2] 五富烯环加成。

  摘要：

  我们开发了在室温下绿光照射下硫代黄鎓光氧化还原催化的五富烯的 [4 + 2] 环加成反应，得到具有高区域选择性的四氢环戊二烯[ b ]色烯。本反应提供了一种可持续的方法来进行五富烯的环加成，而无需使用过渡金属催化剂或高温条件。该程序可以温和而直接地获得 1,3a,9,9a-四氢环戊二烯[ b ]色烯。反应的量子产率（Φ =0.15）表明反应主要通过光催化途径进行。

  DOI：

  10.1039/d0ob01151g

文献信息

• Syntheses, structures and reactions of some new benzyl-substituted cyclopentadienyl titanium complexes
  作者：Yanlong Qian、Jiling Huang、Jimin Yang、Albert S.C. Chan、Weichun Chen、Xiaoping Chen、Li Guisheng、Xianglin Jin、Qingchuan Yang

  DOI：10.1016/s0022-328x(97)00382-3

  日期：1997.12

  benzyl-substituted cyclopentadienyl titanium complex 26 may be spontaneously converted into metallocyclic complex 19. The position of the MeO group on the benzene ring is the key factor to the cyclization. In the case of meta- and para-MeO benzyl-substituted titanium complexes 23 and 25, there was no possibility to form a titanoxacycle complex, such as 19, because the MeO group is too far from titanium. A probable

  已经合成了二十八个新的苄基取代的环戊二烯基钛配合物。其中，通过X射线分析研究了五个典型的分子结构。发现在制备含邻-MeO的苄基取代的钛络合物时，当苄基碳原子上的两个取代基都为Et或更大的基团时，总是形成钛氧环络合物。卤化物的存在促进了环化反应。卤化物对于环化的活性顺序为：LiI-NaI> LiBr-Br 2 > NaBr-KI> KBr> I 2。高温有利于环化。在80°C下，正常的邻-MeO苄基取代的环戊二烯基钛络合物26可以自发地转化成金属环配合物19。MeO基团在苯环上的位置是环化的关键因素。在间-和对-MeO苄基取代的钛配合物23和25的情况下，由于MeO基团距离钛太远，因此不可能形成钛氧杂环丙烷配合物，例如19。提出了一种可能的涉及四元过渡态的机制。
• A Flow Microreactor Approach to a Highly Efficient Diels–Alder Reaction with an Electrogenerated o-Quinone
  作者：Kenta Tanaka、Hirona Yoshizawa、Mahito Atobe

  DOI：10.1055/s-0037-1611725

  日期：2019.6

  reaction of an o-quinone generated in an electrochemical flow microreactor. In the flow microreactor system, 4-tert-butyl-o-benzoquinone was easily electrogenerated from 4-tert-butylpyrocatechol in the absence of chemical oxidants and then rapidly used, without decomposing, in a subsequent Diels–Adler reaction with various fulvenes to give the desired products efficiently.

  我们已经证明了在电化学流动微反应器中产生的邻醌的 Diels-Alder 反应。在流动微反应器系统中，在没有化学氧化剂的情况下，4-叔丁基邻苯醌很容易从 4-叔丁基焦儿茶酚中电生成，然后在随后的 Diels-Adler 反应中与各种富烯反应迅速使用，不会分解，得到有效地获得所需的产品。
• Regioselective electrophilic substitutions of fulvenes with ethyl glyoxylate and subsequent Diels–Alder reactions
  作者：Hsing-Chang Tseng、Arun Kumar Gupta、Bor-Cherng Hong、Ju-Hsiou Liao

  DOI：10.1016/j.tet.2005.11.029

  日期：2006.2

  Highly regioselective electrophilic substitution of fulvenes with ethyl glyoxylate, catalyzed by EtAlCl2 or Yb(OTf)3 was achieved. Subsequent Diels–Alder reaction of the adduct with various dienophiles provides an efficient protocol toward highly functionalized indane and tricyclo[5.2.1.02,6]dec-8-ene systems.

  EtAlCl 2或Yb（OTf）3催化了乙醛酸乙酯对富烯的高度区域选择性亲电取代。加合物与各种亲二烯体的随后狄尔斯-阿尔德反应为高效官能化的茚满和三环[5.2.1.0 2,6 ] dec-8-ene系统提供了一种有效的方案。
• Azadiene Diels−Alder Cycloaddition of Fulvenes:  A Facile Approach to the [1]Pyrindine System
  作者：Bor-Cherng Hong、Jian-Lin Wu、Arun Kumar Gupta、Mahanandeesha Siddappa Hallur、Ju-Hsiou Liao

  DOI：10.1021/ol048762c

  日期：2004.9.1

  Regioselective and stereoselective inverse-electron-demand Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadiene with fulvenes are described. The methodology provides an efficient and novel route to tetrahydro-[1]pyrindine systems.
• Sokolova,E.B. et al., Journal of general chemistry of the USSR, 1967, vol. 37, p. 1509 - 1511
  作者：Sokolova,E.B. et al.

  DOI：——

  日期：——