2-(6-chloro-2-pyridinyl)-1-(3-methoxyphenyl)ethanone | 460079-84-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(6-chloro-2-pyridinyl)-1-(3-methoxyphenyl)ethanone
• 英文别名: 2-(6-Chloropyridin-2-yl)-1-(3-methoxyphenyl)ethanone
• CAS: 460079-84-9
• 化学式: C₁₄H₁₂ClNO₂
• 分子量: 261.708
• InChiKey: GBTOISISHUEIPC-UHFFFAOYSA-N

物化性质

• 沸点：
  394.3±32.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(6-chloro-2-pyridinyl)-1-(3-methoxyphenyl)ethanone 在 palladium diacetate manganese(IV) oxide 、 sodium hydroxide 、 盐酸羟胺 、 sodium ethanolate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 三乙胺 、 三氟乙酸酐 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 8.0h， 生成 N-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-amine
  参考文献：
  名称：

  Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses

  摘要：

  Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.043
• 作为产物：
  描述：

  2-甲基-6-氯吡啶 、 3-甲氧基苯甲酸乙酯 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 生成 2-(6-chloro-2-pyridinyl)-1-(3-methoxyphenyl)ethanone
  参考文献：
  名称：

  Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses

  摘要：

  Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.043

文献信息

• Therapeutic compounds
  申请人：Boyd Leslie F.

  公开号：US20050049260A1

  公开（公告）日：2005-03-03

  The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了公式（I）的化合物：包含它们的药物组合物，制备它们的过程以及它们作为药物代理的用途。
• Therapeutic Compounds
  申请人：Boyd Leslie F.

  公开号：US20060293344A1

  公开（公告）日：2006-12-28

  The present invention provides compounds of formula (I); pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物；包含相同化合物的药物组合物，制备相同化合物的方法以及它们作为药物剂量的使用。
• PYRAZOLOPYRIDINE DERIVATIVES
  申请人：SmithKline Beecham Corporation

  公开号：EP1366048A2

  公开（公告）日：2003-12-03
• US7153855B2
  申请人：——

  公开号：US7153855B2

  公开（公告）日：2006-12-26
• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSES THERAPEUTIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002072581A2

  公开（公告）日：2002-09-19

  The present invention provides compounds of formula (I), pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents, for the prophylaxis and treatment of herpes viral infections.