(3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-1-[(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-4,4,6,8,12-pentamethyltridec-12-ene-1,5-dione | 1469891-36-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-1-[(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-4,4,6,8,12-pentamethyltridec-12-ene-1,5-dione
• 英文别名: (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-1-[(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-4,4,6,8,12-pentamethyltridec-12-ene-1,5-dione
• CAS: 1469891-36-8
• 化学式: C₄₀H₇₅NO₆SSi₂
• 分子量: 754.276
• InChiKey: DAQFRMXJKOZNEL-RQCWMOEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.14
• 重原子数：
  50
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-1-[(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-4,4,6,8,12-pentamethyltridec-12-ene-1,5-dione 在 lithium hydroxide monohydrate 、 双氧水 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.5h， 以56%的产率得到(3S,6R,7S,8S)-3,7-Di-(tert-butyldimethylsilyloxy)-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoic acid
  参考文献：
  名称：

  Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities

  摘要：

  Epothilone D (Epo D) and its 9-Methyl conformational analogues were synthesized through a highly efficient combinatorial approach. The fragment E was synthesized in 11 total steps with 6 longest linear steps, and each aldehyde B was prepared via a 3-step sequence. Starting from the common precursor E and a suitable aldehydes B, each target molecule were obtained in only 4 steps. The 9-(S)-epo D and 9-(R)-epo D demonstrated significant difference in inhibition activities against cancer cell lines and in conformational analysis. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.08.003
• 作为产物：
  描述：

  isopentenylmagnesium bromide 在 2,6-二甲基吡啶 、 四氯化钛 、 二异丁基氢化铝 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 23.0h， 生成 (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-1-[(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-4,4,6,8,12-pentamethyltridec-12-ene-1,5-dione
  参考文献：
  名称：

  Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities

  摘要：

  Epothilone D (Epo D) and its 9-Methyl conformational analogues were synthesized through a highly efficient combinatorial approach. The fragment E was synthesized in 11 total steps with 6 longest linear steps, and each aldehyde B was prepared via a 3-step sequence. Starting from the common precursor E and a suitable aldehydes B, each target molecule were obtained in only 4 steps. The 9-(S)-epo D and 9-(R)-epo D demonstrated significant difference in inhibition activities against cancer cell lines and in conformational analysis. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.08.003

文献信息

• Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities
  作者：Feng Sang、Peng Feng、Jie Chen、Yahui Ding、Xiyan Duan、Jiadai Zhai、Xiaoyan Ma、Bin Zhang、Quan Zhang、Jianping Lin、Yue Chen

  DOI：10.1016/j.ejmech.2013.08.003

  日期：2013.10

  Epothilone D (Epo D) and its 9-Methyl conformational analogues were synthesized through a highly efficient combinatorial approach. The fragment E was synthesized in 11 total steps with 6 longest linear steps, and each aldehyde B was prepared via a 3-step sequence. Starting from the common precursor E and a suitable aldehydes B, each target molecule were obtained in only 4 steps. The 9-(S)-epo D and 9-(R)-epo D demonstrated significant difference in inhibition activities against cancer cell lines and in conformational analysis. (C) 2013 Elsevier Masson SAS. All rights reserved.