5-溴-N-((4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-3-(乙基(四氢-2H-吡喃-4-基)氨基)-2-甲基苯甲酰胺 | 1403257-80-6

物质功能分类

医药中间体 - 原料药中间体

分子结构分类

有机化合物 - 苯类化合物 - 苯和取代衍生物

中文名称

5-溴-N-((4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-3-(乙基(四氢-2H-吡喃-4-基)氨基)-2-甲基苯甲酰胺

中文别名

5-溴-N-((4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-3-(乙基(四氢-2；5-溴-N - ((4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-3-(乙基(四氢-2

英文名称

5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

英文别名

5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(oxan-4-yl)amino)-2-methylbenzamide；5-bromo-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

5-溴-N-((4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基)甲基)-3-(乙基(四氢-2H-吡喃-4-基)氨基)-2-甲基苯甲酰胺化学式

CAS

1403257-80-6

化学式

C₂₃H₃₀BrN₃O₃

mdl

——

分子量

476.413

InChiKey

FADJTYGNEWCCFM-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

642.2±55.0 °C(Predicted)
密度：

1.302±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3.8
重原子数：

30
可旋转键数：

6
环数：

3.0
sp3杂化的碳原子比例：

0.48
拓扑面积：

70.7
氢给体数：

2
氢受体数：

4

安全信息

危险性防范说明：

P261,P280,P301+P312,P302+P352,P305+P351+P338
危险性描述：

H302,H315,H319,H335
储存条件：

2-8°C

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
5-溴-3-(乙基(四氢-2H-吡喃-4-基)氨基)-2-甲基苯甲酸	5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid	1403257-81-7	C₁₅H₂₀BrNO₃	342.233
5-溴-3-(乙基(四氢-2H-吡喃-4-基)氨基)-2-甲基苯甲酸甲酯	methyl 5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate	1403257-79-3	C₁₆H₂₂BrNO₃	356.26

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-(piperidin-4-ylethynyl)benzamide	1598383-62-0	C₃₀H₄₀N₄O₃	504.673
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4,4'-dimethyl-[1,1'-biphenyl]-3-carboxamide	1403255-82-2	C₃₀H₃₇N₃O₃	487.642
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3'-formyl-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403258-10-5	C₃₀H₃₅N₃O₄	501.626
——	4'-(aminomethyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403255-57-1	C₃₀H₃₈N₄O₃	502.657
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-formyl-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403258-06-9	C₃₀H₃₅N₃O₄	501.626
——	4'-(bromomethyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403258-38-7	C₃₀H₃₆BrN₃O₃	566.538
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((dimethylamino)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403255-32-2	C₃₂H₄₂N₄O₃	530.71
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-(hydroxymethyl)-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403255-83-3	C₃₀H₃₇N₃O₄	503.641
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(piperazin-1-ylmethyl)-[1,1'-biphenyl]-3-carboxamide	1403255-41-3	C₃₄H₄₅N₅O₃	571.763
N-[(1,2-二氢-4,6-二甲基-2-氧代-3-吡啶基)甲基]-5-[乙基(四氢-2H-吡喃-4-基)氨基]-4-甲基-4'-(4-吗啉基甲基)-[1,1'-联苯]-3-甲酰胺	tazemetostat	1403254-99-8	C₃₄H₄₄N₄O₄	572.748
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-formyl-2',4-dimethyl-[1,1'-biphenyl]-3-carboxamide	1403258-22-9	C₃₁H₃₇N₃O₄	515.652
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide	1403255-84-4	C₃₄H₄₄N₄O₄	572.748
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3'-fluoro-4'-formyl-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403258-20-7	C₃₀H₃₄FN₃O₄	519.616
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-(1-methyl-1H-pyrazol-4-yl)benzamide	1403255-78-6	C₂₇H₃₅N₅O₃	477.607
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(6-formylpyridin-3-yl)-2-methylbenzamide	1403258-05-8	C₂₉H₃₄N₄O₄	502.613
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholine-4-carbonyl)-[1,1'-biphenyl]-3-carboxamide	1403255-94-6	C₃₄H₄₂N₄O₅	586.731
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-((3-oxomorpholino)methyl)-[1,1'-biphenyl]-3-carboxamide	1403256-02-9	C₃₄H₄₂N₄O₅	586.731
——	4-((3’-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5’-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-methyl-[1,1'-biphenyl]-4-yl)methyl)morpholine 4-oxide	1403256-09-6	C₃₄H₄₄N₄O₅	588.747
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2',4-dimethyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide	1403255-93-5	C₃₅H₄₆N₄O₄	586.775
——	3'-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide	1403256-12-1	C₃₅H₄₃N₅O₄	597.758
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-3'-fluoro-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide	1403255-91-3	C₃₄H₄₃FN₄O₄	590.738
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(6-((dimethylamino)methyl)pyridin-3-yl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide	1403255-79-7	C₃₁H₄₁N₅O₃	531.698
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide	1403258-56-9	C₂₉H₄₂BN₃O₅	523.481
——	N-[(4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-5-(6-methoxypyridin-3-yl)-2-methylbenzamide	——	C₂₉H₃₆N₄O₄	504.6
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2'-fluoro-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide	1403255-92-4	C₃₄H₄₃FN₄O₄	590.738
——	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-(6-(morpholinomethyl)pyridin-3-yl)benzamide	1403255-31-1	C₃₃H₄₃N₅O₄	573.736
——	4'-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide	1403255-35-5	C₃₅H₄₄N₄O₄	584.759
——	2-(3-(5-(3’-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methylcarbamoyl)-5’-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4’-methylbiphenyl-4-yloxy)pentyloxy)isoxazol-5-yl)-3-methylbutanoic acid	——	C₄₂H₅₄N₄O₈	742.913

反应信息

作为反应物：