苦参醇L | 101236-50-4

• 物质功能分类: 天然产物 - 黄酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 苦参醇L
• 中文别名: (2R,3R)-2-(2,4-二羟基苯基)-3,5,7-三羟基-6,8-二(3-甲基丁-2-烯-1-基)-2,3-二氢-4H-色烯-4-酮；苦参醇 L
• 英文名称: Kushenol L
• 英文别名: (2R,3R)-2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
• CAS: 101236-50-4
• 化学式: C₂₅H₂₈O₇
• 分子量: 440.5
• InChiKey: GKENRJIRKFSNED-UKILVPOCSA-N

物化性质

• 沸点：
  715.7±60.0 °C(Predicted)
• 密度：
  1.334±0.06 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

制备方法与用途

生物活性

Kushenol L 是苦参乙醇提取物的主要成分之一，来源于干燥的Sophora flavescens Ait根。它是一种类黄酮，具有抗糖尿病的作用。

体内研究

在成年雄性Sprague-Dawley大鼠（体重300克）中进行的研究表明，Kushenol L (1 mg/kg, 口服) 的半衰期为2.26小时、最大血药浓度(Cmax) 为24.17 μg/L，并且其表观分布容积下的面积(AUC) 为54035 μg/h•L。

文献信息

• GENE NETWORK-BASED METHOD FOR CONFIRMING DRUG ACTION
  申请人：Tsinghua University

  公开号：EP2369493A1

  公开（公告）日：2011-09-28

  The invention provides a network-based method for confirming drug action(drug effect, synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinical drug screening.

  本发明提供了一种基于网络的确认药物作用（药物效应、协同反应）的方法。该方法通过在基因网络中绘制第一药物基因/基因产物子集和第二基因/基因产物子集来实现。第二基因/基因产物子集可以是第二药物基因/基因产物子集，也可以是生物过程基因/基因产物子集。本发明还为临床前药物筛选提供了一种工具。
• AIR FRESHENER COMPOSITION AND PREPARATION METHOD THEREFOR
  申请人：Wang, Jingning

  公开号：EP3388137A1

  公开（公告）日：2018-10-17

  The present invention relates to the field of air cleaning, and specifically discloses an air freshener composition. The air freshener composition comprises component A and component B, wherein a weight ratio of the component A to the component B is 1: 0.5-3; the component A comprises, in parts by weight, 10-30 parts by weight of an active agent; 6-15 parts by weight of a carrier; 1-4 parts by weight of a pH regulator; and 0.01-0.2 part by weight of an antioxidant; the component B is a plant extract solution, wherein the plant extract solution comprises at least, in parts by weight: 5-30 parts by weight of an extract of a mixture of Populus nigra var. italica, grapefruit peels and eucalyptus leaves; 0.1-5 parts by weight of Sophora flavescens extract; 1-3 parts by weight of Aloe vera extract; 1-10 parts by weight of fresh orange peel extract; 0.5-3 parts by weight of Nandina domestica extract; 0.5-10 parts by weight of Eucalyptus robusta Smith extract; 1-8 parts by weight of Robinia pseudoacacia L. extract; 1-5 parts by weight of Chrysanthemum morifolium extract; and 0.1-2 parts by weight of artemisinin.

  本发明涉及空气清洁领域，具体公开了一种空气清新剂组合物。该空气清新剂组合物包括组分 A 和组分 B，其中组分 A 与组分 B 的重量比为 1：0.5-3；组分 A 按重量份数计包括：10-30 份活性剂；6-15 份载体；1-4 份 pH 值调节剂；以及 0.01-0.2 份抗氧化剂；组分 B 为植物提取物溶液，其中植物提取物溶液按重量份数计至少包括：5-30 份黑杨变种、葡萄柚皮和桉树叶的混合物提取物；0.1-5 份桉树叶提取物（按重量份数计）；0.1-0.2 份桉树叶提取物（按重量份数计）；0.1-0.3 份桉树叶提取物（按重量份数计）；0.1-0.4 份桉树叶提取物（按重量份数计）；0.1-0.5 份桉树叶提取物（按重量份数计）。italica、柚子皮和桉树叶的混合物的提取物；0.1-5 份（按重量份数计）白槐提取物；1-3 份（按重量份数计）芦荟提取物；1-10 份（按重量份数计）鲜橙皮提取物；0.5-3 份（按重量份数计）南丹提取物；0.5-10 份（按重量计）桉树提取物；1-8 份（按重量计）洋槐提取物；1-5 份（按重量计）菊花提取物；以及 0.1-2 份（按重量计）青蒿素。
• Air freshener composition and preparation method thereof
  申请人：Wang Jingning

  公开号：US10744219B2

  公开（公告）日：2020-08-18

  The present invention relates to the field of air cleaning, and specifically discloses an air freshener composition. The air freshener composition comprises component A and component B, wherein a weight ratio of the component A to the component B is 1:0.5-3; the component A comprises, in parts by weight, 10-30 parts by weight of an active agent; 6-15 parts by weight of a carrier; 1-4 parts by weight of a pH regulator; and 0.01-0.2 part by weight of an antioxidant; the component B is a plant extract solution, wherein the plant extract solution comprises at least, in parts by weight: 5-30 parts by weight of an extract of a mixture of Populus nigra var. italica, grapefruit peels and eucalyptus leaves; 0.1-5 parts by weight of Sophora flavescens extract; 1-3 parts by weight of Aloe vera extract; 1-10 parts by weight of fresh orange peel extract; 0.5-3 parts by weight of Nandina domestica extract; 0.5-10 parts by weight of Eucalyptus robusta Smith extract; 1-8 parts by weight of Robinia pseudoacacia L. extract; 1-5 parts by weight of Chrysanthemum morifolium extract; and 0.1-2 parts by weight of artemisinin.

  本发明涉及空气净化领域，具体公开了一种空气清新剂组合物。该空气清新剂组合物由组分 A 和组分 B 组成，其中组分 A 与组分 B 的重量比为 1:0.5-3；组分 A 按重量份数计包括：10-30 份活性剂；6-15 份载体；1-4 份 pH 值调节剂；以及 0.01-0.2 份抗氧化剂；组分 B 为植物提取物溶液，其中植物提取物溶液按重量份数计至少包括：5-30 份黑杨变种、柚子皮和桉树叶的混合物提取物；0.1-5 份桉树叶提取物（按重量份数计）；0.1-0.2 份桉树叶提取物（按重量份数计）；0.1-0.3 份桉树叶提取物（按重量份数计）；0.1-0.4 份桉树叶提取物（按重量份数计）；0.1-0.5 份桉树叶提取物（按重量份数计）。italica、柚子皮和桉树叶的混合物的提取物；0.1-5 份（按重量份数计）白槐提取物；1-3 份（按重量份数计）芦荟提取物；1-10 份（按重量份数计）鲜橙皮提取物；0.5-3 份（按重量份数计）南丹提取物；0.5-10 份（按重量计）桉树提取物；1-8 份（按重量计）洋槐提取物；1-5 份（按重量计）菊花提取物；以及 0.1-2 份（按重量计）青蒿素。
• AIR FRESHENER COMPOSITION AND PREPARATION METHOD THEREOF
  申请人：WANG Jingning

  公开号：US20200164096A1

  公开（公告）日：2020-05-28

  The present invention relates to the field of air cleaning, and specifically discloses an air freshener composition. The air freshener composition comprises component A and component B, wherein a weight ratio of the component A to the component B is 1:0.5-3; the component A comprises, in parts by weight, 10-30 parts by weight of an active agent; 6-15 parts by weight of a carrier; 1-4 parts by weight of a pH regulator; and 0.01-0.2 part by weight of an antioxidant; the component B is a plant extract solution, wherein the plant extract solution comprises at least, in parts by weight: 5-30 parts by weight of an extract of a mixture of Populus nigra var. italica , grapefruit peels and eucalyptus leaves; 0.1-5 parts by weight of Sophora flavescens extract; 1-3 parts by weight of Aloe vera extract; 1-10 parts by weight of fresh orange peel extract; 0.5-3 parts by weight of Nandina domestica extract; 0.5-10 parts by weight of Eucalyptus robusta Smith extract; 1-8 parts by weight of Robinia pseudoacacia L. extract; 1-5 parts by weight of Chrysanthemum morifolium extract; and 0.1-2 parts by weight of artemisinin.
• [EN] GENE NETWORK-BASED METHOD FOR CONFIRMING DRUG ACTION<br/>[FR] PROCÉDÉ SELON UN RÉSEAU DE GÈNES POUR CONFIRMER L'ACTION D'UN MÉDICAMENT
  申请人：UNIV TSINGHUA

  公开号：WO2010066150A9

  公开（公告）日：2011-07-21

  [EN] The invention provides a network-based method for confirming drug action(drug effect?synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinial drug screening.
  [FR] L'invention porte sur un procédé selon un réseau pour confirmer l'action d'un médicament (effet de médicament, réaction synergique). Le procédé peut être effectué par la mise en correspondance d'un premier sous-ensemble de gènes/produits de gène de médicament et d'un second sous-ensemble de gènes/produits de gène dans un réseau de gènes. Le second sous-ensemble de gènes/produits de gène peut être un second sous-ensemble de gènes/produits de gène de médicament ou un sous-ensemble de gènes/produits de gène de processus biologique. L'invention porte également sur un outil de criblage avant la partie clinique des études de médicament.