(1E,4E)-1-(3-bromo-4-methoxyphenyl)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one | 1391150-67-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (1E,4E)-1-(3-bromo-4-methoxyphenyl)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
• CAS: 1391150-67-6
• 化学式: C₁₉H₁₇BrO₄
• 分子量: 389.246
• InChiKey: VQWDKDSJBJVXCT-FCXRPNKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1E,4E)-1-(3-bromo-4-methoxyphenyl)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one 在 吡啶 、 palladium 10% on activated carbon 、 氢气 、 potassium carbonate 、 copper(II) oxide 作用下， 以 氯仿 为溶剂， 反应 6.5h， 生成 4,15,19,30-Tetramethoxy-2,17-dioxapentacyclo[26.2.2.213,16.13,7.118,22]hexatriaconta-1(30),3,5,7(36),13,15,18,20,22(33),28,31,34-dodecaene-10,25-dione
  参考文献：
  名称：

  Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling

  摘要：

  Microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling is described. Using the optimized conditions, a panel of macrocycles, with different substitution patterns, ring sizes, and linkers, has been successfully synthesized using microwave irradiation. To the best of our knowledge, this work represents the first examples of the microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.142
• 作为产物：
  描述：

  3-甲氧基-4-[(四氢-2H-吡喃-2-基)氧基]苯甲醛 在 盐酸 、 sodium ethanolate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 (1E,4E)-1-(3-bromo-4-methoxyphenyl)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
  参考文献：
  名称：

  Synthesis and biological evaluation of novel semi-conservative monocarbonyl analogs of curcumin as anti-inflammatory agents

  摘要：

  新型半保守性单羰基类姜黄素类似物已合成并评估其抗炎活性。

  DOI：

  10.1039/c5md00114e

文献信息

• Synthesis and biological evaluation of novel semi-conservative monocarbonyl analogs of curcumin as anti-inflammatory agents
  作者：Zhe Wang、Peng Zou、Chenglong Li、Wenfei He、Bing Xiao、Qilu Fang、Wenbo Chen、Suqing Zheng、Yunjie Zhao、Yuepiao Cai、Guang Liang

  DOI：10.1039/c5md00114e

  日期：——

  Novel semi-conservative monocarbonyl analogs of curcumin were synthesized and evaluated for their anti-inflammatory activities.

  新型半保守性单羰基类姜黄素类似物已合成并评估其抗炎活性。
• Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling
  作者：Li Shen、Charles J. Simmons、Dianqing Sun

  DOI：10.1016/j.tetlet.2012.05.142

  日期：2012.8

  Microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling is described. Using the optimized conditions, a panel of macrocycles, with different substitution patterns, ring sizes, and linkers, has been successfully synthesized using microwave irradiation. To the best of our knowledge, this work represents the first examples of the microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling. (C) 2012 Elsevier Ltd. All rights reserved.