8-羟基喹啉基-β-D-吡喃葡萄糖醛酸钠盐 | 207728-71-0

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 8-羟基喹啉基-β-D-吡喃葡萄糖醛酸钠盐
• 中文别名: 8-羟基喹啉基-Β-D-吡喃葡萄糖醛酸钠盐
• 英文名称: Sodium (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(quinolin-8-yloxy)tetrahydro-2H-pyran-2-carboxylate
• 英文别名: sodium;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-quinolin-8-yloxyoxane-2-carboxylate
• CAS: 207728-71-0
• 化学式: C15H14NNaO7
• 分子量: 343.26
• InChiKey: QYRMLNFJXNJXLO-KSOKONAESA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.82
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• LOADING TECHNIQUE FOR PREPARING RADIONUCLIDE AND IONOPHORE CONTAINING LIPOSOMES IN WHICH THE IONOPHORE IS 2-HYDROXYQUIONOLINE (CARBOSTYRIL) OR STRUCTURALLY RELATED 2-HYDROXYQUINOLINES
  申请人：Technical University of Denmark

  公开号：EP2453927A1

  公开（公告）日：2012-05-23
• ENTRAPMENT OF RADIONUCLIDES IN NANOPARTICLE COMPOSITIONS
  申请人：Technical University of Denmark

  公开号：EP2651447A1

  公开（公告）日：2013-10-23
• LOADING TECHNIQUE FOR PREPARING RADIONUCLIDE CONTAINING NANOPARTICLES
  申请人：Petersen Anncatrine Luisa

  公开号：US20120213698A1

  公开（公告）日：2012-08-23

  The present invention relates to a novel composition and method for loading delivery systems such as liposome compositions with radionuclides useful in targeted diagnostic and/or therapy of target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The composition and methods of the invention find particular use in diagnosing and imaging cancerous tissue and, in general, pathological conditions associated with leaky blood vessels in a subject. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique. One specific aspect of the invention is directed to a method of producing nanoparticles with desired targeting properties for diagnostic and/or radio-therapeutic applications.
• NANOPARTICLE-GUIDED RADIOTHERAPY
  申请人：Andresen Thomas Lars

  公开号：US20130204121A1

  公开（公告）日：2013-08-08

  The present invention relates to a method and nano-sized particles for image guided radiotherapy (IGRT) of a target tissue. More specifically, the invention relates to nano-sized particles comprising X-ray-imaging contrast agents in solid form with the ability to block x-rays, allowing for simultaneous or integrated external beam radiotherapy and imaging, e.g., using computed tomography (CT).
• Entrapment of Radionuclides in Nanoparticle Compositions
  申请人：Petersen Anncatrine Luisa

  公开号：US20130251630A1

  公开（公告）日：2013-09-26

  The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61 Cu and 64 Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.