8-羟基喹啉柠檬酸盐 | 134-30-5

• 物质功能分类: 化学试剂 - 有机试剂 - 芳香酸
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 8-羟基喹啉柠檬酸盐
• 中文别名: 2-羟基-8-羟基喹啉-1,2,3-丙烷三羧酸盐
• 英文名称: 8-Hydroxyquinoline citrate
• 英文别名: 2-hydroxypropane-1,2,3-tricarboxylic acid;quinolin-8-ol
• CAS: 134-30-5
• 化学式: C15H15NO8
• 分子量: 337.28
• InChiKey: GTOQWWQKBBZILU-UHFFFAOYSA-N

物化性质

• 熔点：
  -61 C
• 沸点：
  73-75 C
• 密度：
  0,913 g/cm

计算性质

• 辛醇/水分配系数(LogP)：
  0.69
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  165
• 氢给体数：
  5
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933499090

文献信息

• Method for reducing intraocular pressure using indole derivatives
  申请人：——

  公开号：US20020037887A1

  公开（公告）日：2002-03-28

  The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae I-IV. A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmacuetical composition comprising an indole derivative with or without agents commonly used to treat such disorders. 1

  本发明提供了一种通过给予包含吲哚衍生物的药物组合物来降低眼压的方法。本发明中有用的药物组合物包括吲哚衍生物和公式I-IV的褪黑激素类似物。一种首选实施方式是使用5-(甲氧羰基氨基)-N-乙酰色氨酸（5-MCA-NAT），也称为GR 135531，来降低眼压，其作用持续时间较长，并且在降低眼压方面比褪黑激素具有更高的功效。本发明还提供了一种治疗与眼压升高相关的疾病的方法，以及一种治疗各种青光眼形式的方法；该方法包括给予包含吲哚衍生物的药物组合物的有效剂量，可选择性地与通常用于治疗此类疾病的药物一起使用。
• [EN] SILVER IODATE COMPOUNDS HAVING ANTIMICROBIAL PROPERTIES<br/>[FR] COMPOSÉS D'IODATE D'ARGENT DOTÉS DE PROPRIÉTÉS ANTIMICROBIENNES
  申请人：INNOVOTECH INC

  公开号：WO2012021979A1

  公开（公告）日：2012-02-23

  The present invention is compositions, methods of use, methods of treating, and articles of manufacture that include at least one silver iodate for imparting antimicrobial properties, particularly as it relates to the manufacture, use, and properties of medical devices. The invention also includes obtaining and using one or more silver iodate reaction products from a diperiodatoargentate, wherein the reaction products are obtained using a hydrothermal reaction.

  本发明涉及包含至少一种碘酸银的组合物、使用方法、治疗方法和制品，特别是与医疗器械的制造、使用和性能相关的抗微生物特性。该发明还包括从二碘酸银中获得和使用一个或多个碘酸银反应产物，其中所述反应产物是通过水热反应获得的。
• [EN] SILVER (III) PERIODATES FOR PREVENTING OR REDUCING MICROBIAL CONTAMINATION, AND METHOD FOR THEIR SYNTHESIS<br/>[FR] PÉRIODATES D'ARGENT (III) PERMETTANT DE PRÉVENIR OU DE RÉDUIRE LA CONTAMINATION MICROBIENNE, ET LEUR PROCÉDÉ DE SYNTHÈSE
  申请人：INNOVOTECH INC

  公开号：WO2011072392A1

  公开（公告）日：2011-06-23

  The invention pertains to methods and compositions for preventing or reducing microbial contamination using a silver (III) periodate as antimicrobial active hi a preferred embodiment the silver (III) periodate is used in a coating upon a medical device or implant to confer coating uniformity and antimicrobial efficacy. Also provided is a method of synthetising a silver (III) periodate in high yield by heating a source of single valency silver ions in water and subsequently combining it with a heated solution comprising persulfate, a hy droxide, and a periodate.

  本发明涉及使用银（III）高碘酸盐作为抗微生物活性的方法和组合物，以预防或减少微生物污染。在一种优选实施例中，银（III）高碘酸盐用于涂覆医疗器械或植入物，以赋予涂层均匀性和抗微生物效能。此外，本发明还提供一种高产率合成银（III）高碘酸盐的方法，通过在水中加热单价银离子源，然后将其与包含过硫酸盐、氢氧化物和高碘酸盐的加热溶液结合。
• Bound aggregate composition and support and method of making and using the same to support flowers
  申请人：AGRITEC, INC.

  公开号：EP0018130A1

  公开（公告）日：1980-10-29

  A composition which forms a firm, bound aggregate-water support for floral arrangements with 60%-80% by weight water. The composition comprises a water-insoluble, water-retaining binder, such as a particulate, water-insoluble, water-swellable, cross-linked polymer, and inert non-packing, highly porous water-trapping, aggregate particles dispersed throughout, the particles being present in an amount and having a bulk density and surface area effective to disperse the composition through-out the water as the composition is added to it without hand kneading or stirring. Only sufficient binder, 0.1% to 5.0% by weight, is present to firmly bind the aggregate particles together. Rice hull ash is prefered as the aggregate and the preferred binder is acrylonitrile-starch graft copolymer. The composition can be added to water in a container of any size or shape in an amount sufficient to form the bound aggregate and the composition sinks in and disperses throughout the water and forms a support without the need for mixing with a mixer or kneading with the hands. The aggregate-water support is also used for rooting of some plants and transporting cut flowers.

  一种组合物，可在插花中形成牢固的、与水结合的聚合支撑，含水量为 60%-80% （重量百分比）。该组合物包括一种不溶于水的保水粘合剂，如一种颗粒状、不溶于水、可在水中膨胀的交联聚合物，以及分散在水中的惰性、非包装、高多孔性、吸水性的骨料颗粒，这些颗粒的存在量和体积密度及表面积能有效地将组合物分散到水中，而无需人工揉捏或搅拌。只有足够的粘合剂（0.1% 至 5.0%（按重量计））才能将聚合颗粒牢固地粘合在一起。最好用稻壳灰作为骨料，粘合剂最好是丙烯腈-淀粉接枝共聚物。可将组合物加入任何大小或形状的容器中的水中，加入量足以形成结合的骨料，组合物会沉入水中并分散到整个水中，无需用搅拌器搅拌或用手揉搓即可形成支撑物。骨料-水支架还可用于某些植物的生根和切花的运输。
• Substrate treated with lotion
  申请人：Fort James Corporation

  公开号：EP0875233A1

  公开（公告）日：1998-11-04

  A substrate treated with a lotion including an emollient and a retention/release agent, wherein the lotion has at least one of: (a) a ΔH above about 37 °C of above about 10 calories/gram (and optionally, a ΔH below about 37 °C of above about 15 calories/gram), a total heat of melting of above about 25 calories/gram, preferably above about 30 calories/gram, and an onset of melting temperature of at least about 30 °C, preferably from about 30 °C to about 45 °C; and (b) a ΔH above about 30 °C of above about 15 calories/gram (and optionally, a ΔH below about 30 °C of above about 10 calories/gram), a total heat of melting of above about 25 calories/gram, preferably above about 30 calories/gram, and an onset of melting temperature of at least about 30 °C, preferably from about 30 °C to about 45 °C is disclosed. Preferably the lotion includes an aromatic ester or fatty alcohol ester of a non-fatty organic acid emollient or mixture thereof and a retention/release agent, and optionally, surfactant, and/or medicinal agent. The lotion has the effect of making the treated substrate, preferably tissue, towel or napkin, optionally wet-strengthened, wipe or nonwoven material, feel smooth, lubricious and nongreasy. The skin care benefits of the lotionized substrate are expressed whether the product is used dry or prewetted with water.

  一种用包括润肤剂和滞留/释放剂的乳液处理的基质，其中乳液具有以下至少一项：(a) ΔH 高于约 37 °C，高于约 10 卡路里/克（可选，ΔH 低于约 37 °C，高于约 15 卡路里/克），总熔化热高于约 25 卡路里/克，最好高于约 30 卡路里/克，开始熔化温度至少约 30 °C，最好约 30 °C至约 45 °C；(b) ΔH高于约30°C，高于约15卡路里/克（可选，ΔH低于约30°C，高于约10卡路里/克），总熔化热高于约25卡路里/克，最好高于约30卡路里/克，开始熔化温度至少约30°C，最好约30°C至约45°C。优选地，乳液包括非脂肪有机酸润肤剂的芳香酯或脂肪醇酯或它们的混合物，以及保留/释放剂，可选地，表面活性剂和/或药剂。乳液的作用是使处理过的基质，最好是纸巾、毛巾或餐巾，也可以是湿加固、擦拭或无纺材料，感觉光滑、润滑和不油腻。无论产品是干用还是用水预湿，乳液基材都能体现出护肤功效。